Health-related quality of life, obesity, fragmented sleep, fatigue, and psychosocial problems among youth with craniopharyngioma.
craniopharyngioma
fatigue
obesity
psycho-oncology
psychosocial functioning
quality of life
sleep
Journal
Psycho-oncology
ISSN: 1099-1611
Titre abrégé: Psychooncology
Pays: England
ID NLM: 9214524
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
revised:
18
10
2021
received:
30
06
2021
accepted:
15
11
2021
pubmed:
4
12
2021
medline:
7
5
2022
entrez:
3
12
2021
Statut:
ppublish
Résumé
Youth with craniopharyngioma experience weight gain, fragmented sleep, excessive daytime sleepiness (EDS), fatigue, and psychosocial problems that negatively impact their overall health-related quality of life (HRQoL). Greater hypothalamic tumor involvement (HI) may be associated with higher rates or severity of these impairments; however, the direct and indirect impact of HI on the physical and psychosocial consequences associated with pediatric craniopharyngioma remain unclear. The purpose of the current study was to examine relations between HI, body mass index (BMI), fragmented sleep, EDS, fatigue, psychosocial problems, and HRQoL among youth with craniopharyngioma. Eighty-four youth with craniopharyngioma (M Hypothalamic tumor involvement was associated with greater BMI (Est. = 2.97, p = 0.003) and daytime sleepiness (Est. = 2.53, p = 0.01). Greater fatigue predicted more psychosocial problems (Est. = 0.29, p < 0.001) and lower HRQoL (Est. = 0.23, p = 0.001). Psychosocial problems also predicted lower HRQoL (Est. = -0.34, p = 0.004). Fragmented sleep (Est. = 0.03, p = 0.04) and fatigue (Est. = 0.10, p = 0.02) indirectly predicted lower HRQoL through psychosocial problems. Youth with craniopharyngioma with greater HI may benefit from weight reduction interventions and management of excessive sleepiness. Patients should be prospectively monitored for sleep problems, fatigue, and psychosocial problems, as these patients may benefit from interventions targeting fatigue and psychosocial health to improve HRQoL.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
779-787Informations de copyright
© 2021 John Wiley & Sons Ltd.
Références
Müller H. Risk-adapted, long-term management in childhood-onset craniopharyngioma. Pituitary. 2017;20(2):267-281.
De Vile CJ, Grant DB, Kendall BE, et al. Management of childhood craniopharyngioma: can the morbidity of radical surgery be predicted? J Neurosurg. 1996;85(1):73-81.
Poretti A, Grotzer MA, Ribi K, Schönle E, Boltshauser E. Outcome of craniopharyngioma in children: long-term complications and quality of life. Dev Med Child Neurol. 2004;46(4):220-229.
Jacola LM, Conklin HM, Scoggins MA, et al. Investigating the role of hypothalamic tumor involvement in sleep and cognitive outcomes among children treated for craniopharyngioma. J Pediatr Psychol. 2016;41(6):610-622.
Müller H, Gebhardt U, Teske C, et al. Post-operative hypothalamic lesions and obesity in childhood craniopharyngioma: results of the multinational prospective trial KRANIOPHARYNGEOM 2000 after 3-year follow-up. Eur J Endocrinol. 2011;165(1):17-24.
Rosen G, Brand S. Sleep in children with cancer: case review of 70 children evaluated in a comprehensive pediatric sleep center. Support Care Cancer. 2011;19(7):985-994.
Mandrell BN, LaRosa K, Hancock D, et al. Predictors of narcolepsy and hypersomnia due to medical disorder in pediatric craniopharyngioma. J Neuro Oncol. 2020;148:307-316.
Lipton J, Megerian J, Kothare S, et al. Melatonin deficiency and disrupted circadian rhythms in pediatric survivors of craniopharyngioma. Neurol. 2009;73(4):323-325.
Müller H. Increased daytime sleepiness in patients with childhood craniopharyngioma and hypothalamic tumor involvement: review of the literature and perspectives. Int J Endocrinol. 2010;2010.
Harz KJ, Müller HL, Waldeck E, Pudel V, Roth C. Obesity in patients with craniopharyngioma: assessment of food intake and movement counts indicating physical activity. J Clin Endocrinol Metabol. 2003;88(11):5227-5231.
Lustig RH. Hypothalamic obesity after craniopharyngioma: mechanisms, diagnosis, and treatment. Front Endocrinol. 2011;2:60.
Gozal D, Kheirandish-Gozal L. Obesity and excessive daytime sleepiness in prepubertal children with obstructive sleep apnea. Pediatr. 2009;123(1):13-18.
Müller H, Handwerker G, Wollny B, Faldum A, Sörensen N. Melatonin secretion and increased daytime sleepiness in childhood craniopharyngioma patients. J Clin Endocrinol Metabol. 2002;87(8):3993-3996.
Mehren A, Özyurt J, zu Klampen P, Boekhoff S, Thiel CM, Müller HL. Self-and informant-rated apathy in patients with childhood-onset craniopharyngioma. J Neuro Oncol. 2018;140(1):27-35.
Sterkenburg AS, Hoffmann A, Gebhardt U, Warmuth-Metz M, Daubenbüchel AM, Müller HL. Survival, hypothalamic obesity, and neuropsychological/psychosocial status after childhood-onset craniopharyngioma: newly reported long-term outcomes. Neuro Oncol. 2015;17(7):1029-1038.
Zada G, Kintz N, Pulido M, Amezcua L. Prevalence of neurobehavioral, social, and emotional dysfunction in patients treated for childhood craniopharyngioma: a systematic literature review. PLoS One. 2013;8(11):e76562.
Ondruch A, Maryniak A, Kropiwnicki T, Roszkowski M, Daszkiewicz P. Cognitive and social functioning in children and adolescents after the removal of craniopharyngioma. Child's Nerv Syst. 2011;27(3):391-397.
Littner MR, Kushida C, Wise M, et al. Practice parameters for clinical use of the multiple sleep latency test and the maintenance of wakefulness test. Sleep. 2005;28(1):113-121.
Mindell JA, Owens JA. A Clinical Guide to Pediatric Sleep: Diagnosis and Management of Sleep Problems. Lippincott Williams & Wilkins; 2015.
Sadeh A, Hauri P, Kripke D, Lavie P. The role of actigraphy in the evaluation of sleep disorders. Sleep. 1995;18(4):288-302.
Sadeh A. The role and validity of actigraphy in sleep medicine: an update. Sleep Med Rev. 2011;15(4):259-267.
Varni JW, Burwinkle TM, Szer IS. The PedsQL Multidimensional Fatigue Scale in pediatric rheumatology: reliability and validity. J Rheumatol. 2004;31(12):2494-2500.
Varni JW, Burwinkle TM, Limbers CA, Szer IS. The PedsQL™ as a patient-reported outcome in children and adolescents with fibromyalgia: an analysis of OMERACT domains. Health Qual Life Outcomes. 2007;5(1):9.
Palmer SN, Meeske KA, Katz ER, Burwinkle TM, Varni JW. The PedsQL™ brain tumor module: initial reliability and validity. Pediatr Blood Cancer. 2007;49(3):287-293.
Kuczmarski RJ. 2000 CDC Growth Charts for the United States: Methods and Development (No. 246). Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Health Statistics; 2002.
Cole T, Green P. Smoothing reference centile curves: the LMS method and penalized likelihood. Stat Med. 1992;11(10):1305-1319.
Reynolds CR, Kamphaus RW. Behavior assessment system for children-(BASC-2). AGS; 1992.
Nevitt J, Hancock GR. Performance of bootstrapping approaches to model test statistics and parameter standard error estimation in structural equation modeling. Struct Equ Model. 2001;8(3):353-377.
Browne MW, Cudeck R. Alternative Ways of Assessing Model Fit. Sage; 1993.
Calhoun SL, Vgontzas AN, Fernandez-Mendoza J, et al. Prevalence and risk factors of excessive daytime sleepiness in a community sample of young children: the role of obesity, asthma, anxiety/depression, and sleep. Sleep. 2011;34(4):503-507.
Daniel L, Kazak AE, Li Y, et al. Relationship between sleep problems and psychological outcomes in adolescent and young adult cancer survivors and controls. Support Care Cancer. 2016;24(2):539-546.
Meeske K, Siegel S, Globe D, Mack W, Bernstein L. Prevalence and correlates of fatigue in long-term survivors of childhood leukemia. J Clin Oncol. 2005;23(24):5501-5510.
Dahl RE, ed. The impact of inadequate sleep on children's daytime cognitive function. Seminars in pediatric neurology. Elsevier; 1996.
Meeske K, Katz E, Palmer S, Burwinkle T, Varni J. Parent proxy-reported health-related quality of life and fatigue in pediatric patients diagnosed with brain tumors and acute lymphoblastic leukemia. Cancer. 2004;101(9):2116-2125.
Meeske K, Patel S, Palmer S, Nelson M, Parow A. Factors associated with health-related quality of life in pediatric cancer survivors. Pediatr Blood Cancer. 2007;49(3):298-305.
Müller H, Müller-Stöver S, Gebhardt U, Kolb R, Sörensen N, Handwerker G. Secondary narcolepsy may be a causative factor of increased daytime sleepiness in obese childhood craniopharyngioma patients. J Pediatr Endocrinol Metabol. 2006;19:423-429.
Slater G, Steier J. Excessive daytime sleepiness in sleep disorders. J Thorac Dis. 2012;4(6):608.
Faber J, Fonseca L. How sample size influences research outcomes. Dent Press J Orthod. 2014;13(4):27-29.
Cribbie RA. Multiplicity control in structural equation modeling. Struct Equ Model A Multidiscip J. 2007;14(1):98-112.
Levi R, Drotar D. Health-related quality of life in childhood cancer: discrepancy in parent-child reports. Int J Cancer. 1999;83(12):58-64.
Cohen M, Guger SL, Hamilton J. Long term sequelae of pediatric craniopharyngioma-literature review and 20 years of experience. Front Endocrinol. 2011;2:81.
Haliloglu B, Bereket A. Hypothalamic obesity in children: pathophysiology to clinical management. J Pediatr Endocrinol Metabol. 2015;28(5-6):503-513.
Agudelo HAM, Correa UJ, Sierra JC, Pandi-Perumal SR, Schenck CH. Cognitive behavioral treatment for narcolepsy: can it complement pharmacotherapy? Sleep Sci. 2014;7(1):30-42.