In vivo genome-wide CRISPR screens identify SOCS1 as intrinsic checkpoint of CD4

Animals CD4-Positive T-Lymphocytes / immunology Clustered Regularly Interspaced Short Palindromic Repeats / immunology Female Male Mice Mice, Knockout Mice, Transgenic Suppressor of Cytokine Signaling 1 Protein / immunology Th1 Cells / immunology

Journal

Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624

Informations de publication

Date de publication:
03 Dec 2021
Historique:
entrez: 3 12 2021
pubmed: 4 12 2021
medline: 8 3 2022
Statut: ppublish

Résumé

Although CD8

Identifiants

DOI: 10.1126/sciimmunol.abe8219 PMID: 34860579
pubmed: 34860579
doi: 10.1126/sciimmunol.abe8219
doi:

Substances chimiques

Socs1 protein, mouse 0
Suppressor of Cytokine Signaling 1 Protein 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

eabe8219

Auteurs

Aurélien Sutra Del Galy (A)

AP-HP Hospital Saint Louis, Hematology/Transplantation, Paris 75010, France.
ORCID: 0000-0002-4716-1472

Silvia Menegatti (S)

INSERM U932, PSL University, Institut Curie, Paris 75005, France.
ORCID: 0000-0002-8155-9169

Jaime Fuentealba (J)

INSERM U932, PSL University, Institut Curie, Paris 75005, France.

Francesca Lucibello (F)

INSERM U932, PSL University, Institut Curie, Paris 75005, France.

Laetitia Perrin (L)

INSERM U932, PSL University, Institut Curie, Paris 75005, France.

Julie Helft (J)

INSERM U932, PSL University, Institut Curie, Paris 75005, France.
ORCID: 0000-0002-2733-1972

Aurélie Darbois (A)

INSERM U932, PSL University, Institut Curie, Paris 75005, France.

Michael Saitakis (M)

INSERM U932, PSL University, Institut Curie, Paris 75005, France.
ORCID: 0000-0002-6355-4225

Jimena Tosello (J)

INSERM U932, PSL University, Institut Curie, Paris 75005, France.
ORCID: 0000-0003-1563-4420

Derek Rookhuizen (D)

INSERM U932, PSL University, Institut Curie, Paris 75005, France.

Marc Deloger (M)

INSERM US23, CNRS UMS 3655, Gustave Roussy Cancer Campus, 94800 Villejuif, France.
ORCID: 0000-0002-6352-101X

Pierre Gestraud (P)

Bioinformatics and Computational Systems Biology of Cancer, PSL Research University, MINES ParisTech, INSERM U900, Paris 75005, France.
ORCID: 0000-0002-3893-9879

Gérard Socié (G)

AP-HP Hospital Saint Louis, Hematology/Transplantation, Paris 75010, France.
ORCID: 0000-0002-2114-7533

Sebastian Amigorena (S)

INSERM U932, PSL University, Institut Curie, Paris 75005, France.
ORCID: 0000-0001-8583-8416

Olivier Lantz (O)

INSERM U932, PSL University, Institut Curie, Paris 75005, France.
Laboratoire d'immunologie clinique, Institut Curie, Paris 75005, France.
Centre d'investigation Clinique en Biothérapie Gustave-Roussy Institut Curie (CIC-BT1428), Institut Curie, Paris 75005, France.
ORCID: 0000-0003-3161-7719

Laurie Menger (L)

INSERM U932, PSL University, Institut Curie, Paris 75005, France.
ORCID: 0000-0003-0949-6607

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › In vivo genome-wide CRISPR screens identify...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › In vivo genome-wide CRISPR screens identify...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Séquences répétées en tandem › Clustered regularly interspaced short palindromic repeats › In vivo genome-wide CRISPR screens identify...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › In vivo genome-wide CRISPR screens identify...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › In vivo genome-wide CRISPR screens identify...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › In vivo genome-wide CRISPR screens identify...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines adaptatrices de la transduction du signal › Protéines SOCS › Protéine-1 suppressive de la signalisation des cytokines › In vivo genome-wide CRISPR screens identify...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T auxiliaires › Lymphocytes auxiliaires Th1 › In vivo genome-wide CRISPR screens identify...