Design, synthesis, anticancer, and docking of some S- and/or N-heterocyclic derivatives as VEGFR-2 inhibitors.
Animals
Antineoplastic Agents
/ chemical synthesis
Breast Neoplasms
/ drug therapy
Carcinoma, Hepatocellular
/ drug therapy
Chlorocebus aethiops
Doxorubicin
/ pharmacology
Female
Hep G2 Cells
Heterocyclic Compounds
/ chemical synthesis
Humans
Inhibitory Concentration 50
Liver Neoplasms
/ drug therapy
MCF-7 Cells
Molecular Docking Simulation
Sorafenib
/ pharmacology
Structure-Activity Relationship
Vascular Endothelial Growth Factor Receptor-2
/ antagonists & inhibitors
Vero Cells
ADMET profile
VEGFR-2
anticancer
molecular docking
Journal
Archiv der Pharmazie
ISSN: 1521-4184
Titre abrégé: Arch Pharm (Weinheim)
Pays: Germany
ID NLM: 0330167
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
revised:
15
10
2021
received:
01
07
2021
accepted:
21
10
2021
pubmed:
5
12
2021
medline:
12
3
2022
entrez:
4
12
2021
Statut:
ppublish
Résumé
Novel heterocyclic derivatives (4-22) were designed, synthesized, and evaluated against hepatocellular carcinoma type (HepG2) and breast cancer (MCF-7) cells, targeting the VEGFR-2 enzyme. Compounds 18, 10, 13, 11, and 14 were found to be the most potent derivatives against both the HepG2 and MCF-7 cancer cell lines, with GI
Identifiants
pubmed: 34862655
doi: 10.1002/ardp.202100237
doi:
Substances chimiques
Antineoplastic Agents
0
Heterocyclic Compounds
0
Doxorubicin
80168379AG
Sorafenib
9ZOQ3TZI87
KDR protein, human
EC 2.7.10.1
Vascular Endothelial Growth Factor Receptor-2
EC 2.7.10.1
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2100237Informations de copyright
© 2021 Deutsche Pharmazeutische Gesellschaft.
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