METTL14 gene polymorphisms decrease Wilms tumor susceptibility in Chinese children.

Asian People Case-Control Studies Child Female Genetic Predisposition to Disease Genotype Humans Male Methyltransferases / metabolism Polymorphism, Genetic / genetics Polymorphism, Single Nucleotide / genetics Wilms Tumor / genetics
Case-control study METTL14 Polymorphism Risk Wilms tumor

Journal

BMC cancer
ISSN: 1471-2407
Titre abrégé: BMC Cancer
Pays: England
ID NLM: 100967800

Informations de publication

Date de publication:
04 Dec 2021
Historique:
received: 02 06 2021
accepted: 18 11 2021
entrez: 5 12 2021
pubmed: 6 12 2021
medline: 23 2 2022
Statut: epublish

Résumé

Wilms tumor is a highly heritable malignancy. Aberrant METTL14, a critical component of N6-methyladenosine (m A total of 403 patients and 1198 controls were analyzed. METTL14 genotypes were assessed by TaqMan genotyping assay. Among the five SNPs analyzed, rs1064034 T > A and rs298982 G > A exhibited a significant association with decreased susceptibility to Wilms tumor. Moreover, the joint analysis revealed that the combination of five protective genotypes exerted significantly more protective effects against Wilms tumor than 0-4 protective genotypes with an OR of 0.69. The stratified analysis further identified the protective effect of rs1064034 T > A, rs298982 G > A, and combined five protective genotypes in specific subgroups. The above significant associations were further validated by haplotype analysis and false-positive report probability analysis. Preliminary mechanism exploration indicated that rs1064034 T > A and rs298982 G > A are correlated with the expression and splicing event of their surrounding genes. Collectively, our results suggest that METTL14 gene SNPs may be genetic modifiers for the development of Wilms tumor.

Sections du résumé

BACKGROUND BACKGROUND
Wilms tumor is a highly heritable malignancy. Aberrant METTL14, a critical component of N6-methyladenosine (m
METHODS METHODS
A total of 403 patients and 1198 controls were analyzed. METTL14 genotypes were assessed by TaqMan genotyping assay.
RESULT RESULTS
Among the five SNPs analyzed, rs1064034 T > A and rs298982 G > A exhibited a significant association with decreased susceptibility to Wilms tumor. Moreover, the joint analysis revealed that the combination of five protective genotypes exerted significantly more protective effects against Wilms tumor than 0-4 protective genotypes with an OR of 0.69. The stratified analysis further identified the protective effect of rs1064034 T > A, rs298982 G > A, and combined five protective genotypes in specific subgroups. The above significant associations were further validated by haplotype analysis and false-positive report probability analysis. Preliminary mechanism exploration indicated that rs1064034 T > A and rs298982 G > A are correlated with the expression and splicing event of their surrounding genes.
CONCLUSIONS CONCLUSIONS
Collectively, our results suggest that METTL14 gene SNPs may be genetic modifiers for the development of Wilms tumor.

Identifiants

DOI: 10.1186/s12885-021-09019-5 PMID: 34863142 PMC: PMC8643011
pubmed: 34863142
doi: 10.1186/s12885-021-09019-5
pii: 10.1186/s12885-021-09019-5
pmc: PMC8643011
doi:

Substances chimiques

METTL14 protein, human EC 2.1.1.-
Methyltransferases EC 2.1.1.-

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1294

Informations de copyright

© 2021. The Author(s).

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Auteurs

Zhenjian Zhuo (Z)

Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 9 Jinsui Road, Guangzhou, 510623, Guangdong, China.

Rui-Xi Hua (RX)

Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 9 Jinsui Road, Guangzhou, 510623, Guangdong, China.

Huizhu Zhang (H)

Department of Gynaecology and Obstetrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510623, Guangdong, China.

Huiran Lin (H)

Faculty of Medicine, Macau University of Science and Technology, Macau, 999078, China.

Wen Fu (W)

Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 9 Jinsui Road, Guangzhou, 510623, Guangdong, China.

Jinhong Zhu (J)

Department of Clinical Laboratory, Biobank, Harbin Medical University Cancer Hospital, Harbin, 150040, Heilongjiang, China.

Jiwen Cheng (J)

Department of Pediatric Surgery, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, Shaanxi, China.

Jiao Zhang (J)

Department of Pediatric Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.

Suhong Li (S)

Department of Pathology, Children Hospital and Women Health Center of Shanxi, Shannxi, Taiyuan, 030013, China.

Haixia Zhou (H)

Department of Hematology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, Zhejiang, China.

Huimin Xia (H)

Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 9 Jinsui Road, Guangzhou, 510623, Guangdong, China.

Guochang Liu (G)

Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 9 Jinsui Road, Guangzhou, 510623, Guangdong, China.

Wei Jia (W)

Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 9 Jinsui Road, Guangzhou, 510623, Guangdong, China. jiawei198044@hotmail.com.

Jing He (J)

Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 9 Jinsui Road, Guangzhou, 510623, Guangdong, China. hejing198374@gmail.com.

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Classifications MeSH

questionsmedicales.fr › Personnes › Asiatiques › METTL14 gene polymorphisms decrease Wilms...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › METTL14 gene polymorphisms decrease Wilms...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › METTL14 gene polymorphisms decrease Wilms...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › METTL14 gene polymorphisms decrease Wilms...
questionsmedicales.fr › Phénomènes génétiques › Génotype › METTL14 gene polymorphisms decrease Wilms...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › METTL14 gene polymorphisms decrease Wilms...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › One-carbon group transferases › Methyltransferases › METTL14 gene polymorphisms decrease Wilms...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › METTL14 gene polymorphisms decrease Wilms...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › METTL14 gene polymorphisms decrease Wilms...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Maladies génétiques congénitales › Syndromes néoplasiques héréditaires › Tumeur de Wilms › METTL14 gene polymorphisms decrease Wilms...