Substrate-dependent differential regulation of mitochondrial bioenergetics in the heart and kidney cortex and outer medulla.

Hydrogen Peroxide
Membrane potential Mitochondrial bioenergetics Oxidative phosphorylation ROS production Respiration Reverse electron transport Substrate metabolism

Journal

Biochimica et biophysica acta. Bioenergetics
ISSN: 1879-2650
Titre abrégé: Biochim Biophys Acta Bioenerg
Pays: Netherlands
ID NLM: 101731706

Informations de publication

Date de publication:
01 02 2022
Historique:
received: 21 05 2021
revised: 29 10 2021
accepted: 20 11 2021
pubmed: 6 12 2021
medline: 17 2 2022
entrez: 5 12 2021
Statut: ppublish

Résumé

The kinetics and efficiency of mitochondrial oxidative phosphorylation (OxPhos) can depend on the choice of respiratory substrates. Furthermore, potential differences in this substrate dependency among different tissues are not well-understood. Here, we determined the effects of different substrates on the kinetics and efficiency of OxPhos in isolated mitochondria from the heart and kidney cortex and outer medulla (OM) of Sprague-Dawley rats. The substrates were pyruvate+malate, glutamate+malate, palmitoyl-carnitine+malate, alpha-ketoglutarate+malate, and succinate±rotenone at saturating concentrations. The kinetics of OxPhos were interrogated by measuring mitochondrial bioenergetics under different ADP perturbations. Results show that the kinetics and efficiency of OxPhos are highly dependent on the substrates used, and this dependency is distinctly different between heart and kidney. Heart mitochondria showed higher respiratory rates and OxPhos efficiencies for all substrates in comparison to kidney mitochondria. Cortex mitochondria respiratory rates were higher than OM mitochondria, but OM mitochondria OxPhos efficiencies were higher than cortex mitochondria. State 3 respiration was low in heart mitochondria with succinate but increased significantly in the presence of rotenone, unlike kidney mitochondria. Similar differences were observed in mitochondrial membrane potential. Differences in H

Identifiants

DOI: 10.1016/j.bbabio.2021.148518 PMID: 34864090 PMC: PMC8957717
pubmed: 34864090
pii: S0005-2728(21)00151-1
doi: 10.1016/j.bbabio.2021.148518
pmc: PMC8957717
mid: NIHMS1789107
pii:
doi:

Substances chimiques

Hydrogen Peroxide BBX060AN9V

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

148518

Subventions

Organisme : NHLBI NIH HHS
ID : P01 HL116264
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL151587
Pays : United States

Informations de copyright

Copyright © 2021. Published by Elsevier B.V.

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Auteurs

Namrata Tomar (N)

Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee WI-53226, United States of America.

Xiao Zhang (X)

Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee WI-53226, United States of America.

Sunil M Kandel (SM)

Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee WI-53226, United States of America.

Shima Sadri (S)

Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee WI-53226, United States of America.

Chun Yang (C)

Department of Physiology, Medical College of Wisconsin, Milwaukee WI-53226, United States of America.

Mingyu Liang (M)

Department of Physiology, Medical College of Wisconsin, Milwaukee WI-53226, United States of America; Center of Systems Molecular Medicine, Medical College of Wisconsin, Milwaukee WI-53226, United States of America.

Said H Audi (SH)

Department of Biomedical Engineering, Marquette University, Milwaukee WI-53223, United States of America.

Allen W Cowley (AW)

Department of Physiology, Medical College of Wisconsin, Milwaukee WI-53226, United States of America; Center of Systems Molecular Medicine, Medical College of Wisconsin, Milwaukee WI-53226, United States of America. Electronic address: cowley@mcw.edu.

Ranjan K Dash (RK)

Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee WI-53226, United States of America; Department of Physiology, Medical College of Wisconsin, Milwaukee WI-53226, United States of America; Center of Systems Molecular Medicine, Medical College of Wisconsin, Milwaukee WI-53226, United States of America. Electronic address: rdash@mcw.edu.

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Radicaux libres › Peroxydes › Peroxyde d'hydrogène › Substrate-dependent differential regulation of...