Population-specific diversity of the immunoglobulin constant heavy G chain (IGHG) genes.
Journal
Genes and immunity
ISSN: 1476-5470
Titre abrégé: Genes Immun
Pays: England
ID NLM: 100953417
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
received:
01
09
2021
accepted:
22
11
2021
revised:
11
11
2021
pubmed:
6
12
2021
medline:
14
1
2022
entrez:
5
12
2021
Statut:
ppublish
Résumé
Human immunoglobulin G (IgG) molecules, IgG1, IgG2 and IgG3, exhibit substantial inter-individual variation in their constant heavy chain regions, as discovered by serological methods. This polymorphism is encoded by the IGHG1, IGHG2, and IGHG3 genes and may influence antibody function. We sequenced the coding fragments of these genes in 95 European Americans, 94 African Americans, and 94 Black South Africans. Striking differences were observed between the population groups, including extremely low amino acid sequence variation in IGHG1 among South Africans, and higher IGHG2 and IGHG3 diversity in individuals of African descent compared to individuals of European descent. Molecular definition of the loci illustrates a greater level of allelic polymorphism than previously described, including the presence of common IGHG2 and IGHG3 variants that were indistinguishable serologically. Comparison of our data with the 1000 Genome Project sequences indicates overall agreement between the datasets, although some inaccuracies in the 1000 Genomes Project are likely. These data represent the most comprehensive analysis of IGHG polymorphisms across major populations, which can now be applied to deciphering their functional impact.
Identifiants
pubmed: 34864821
doi: 10.1038/s41435-021-00156-2
pii: 10.1038/s41435-021-00156-2
pmc: PMC8674132
doi:
Substances chimiques
Immunoglobulin G
0
Immunoglobulin Heavy Chains
0
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
327-334Subventions
Organisme : NCI NIH HHS
ID : HHSN261200800001E
Pays : United States
Informations de copyright
© 2021. The Author(s).
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