Melanocortin 1 Receptor Deficiency in Hematopoietic Cells Promotes the Expansion of Inflammatory Leukocytes in Atherosclerotic Mice.

Animals Atherosclerosis / etiology Biomarkers Blood Cells / metabolism CD4-Positive T-Lymphocytes / immunology Cytokines / metabolism Disease Models, Animal Disease Susceptibility Immunophenotyping Inflammation Mediators / metabolism Leukocytes / metabolism Mice Mice, Knockout Receptor, Melanocortin, Type 1 / deficiency
CD4+ T cell atherosclerosis bone marrow transplantation hematopoiesis inflammation leukocyte migration leukocytosis melanocortin 1 receptor

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2021
Historique:
received: 10 09 2021
accepted: 03 11 2021
entrez: 6 12 2021
pubmed: 7 12 2021
medline: 11 2 2022
Statut: epublish

Résumé

Melanocortin receptor 1 (MC1-R) is expressed in leukocytes, where it mediates anti-inflammatory actions. We have previously observed that global deficiency of MC1-R signaling perturbs cholesterol homeostasis, increases arterial leukocyte accumulation and accelerates atherosclerosis in apolipoprotein E knockout (Apoe

Identifiants

DOI: 10.3389/fimmu.2021.774013 PMID: 34868038 PMC: PMC8640177
pubmed: 34868038
doi: 10.3389/fimmu.2021.774013
pmc: PMC8640177
doi:

Substances chimiques

Biomarkers 0
Cytokines 0
Inflammation Mediators 0
Receptor, Melanocortin, Type 1 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

774013

Informations de copyright

Copyright © 2021 Kadiri, Tadayon, Thapa, Suominen, Hollmén and Rinne.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

James J Kadiri (JJ)

Research Centre for Integrative Physiology & Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland.
Drug Research Doctoral Programme (DRDP), University of Turku, Turku, Finland.

Sina Tadayon (S)

MediCity Research Laboratory, University of Turku, Turku, Finland.

Keshav Thapa (K)

Research Centre for Integrative Physiology & Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland.
Drug Research Doctoral Programme (DRDP), University of Turku, Turku, Finland.

Anni Suominen (A)

Research Centre for Integrative Physiology & Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland.
Drug Research Doctoral Programme (DRDP), University of Turku, Turku, Finland.

Maija Hollmén (M)

MediCity Research Laboratory, University of Turku, Turku, Finland.

Petteri Rinne (P)

Research Centre for Integrative Physiology & Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland.
Turku Center for Disease Modeling, University of Turku, Turku, Finland.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Melanocortin 1 Receptor Deficiency in...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Artériopathies oblitérantes › Artériosclérose › Athérosclérose › Melanocortin 1 Receptor Deficiency in...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Melanocortin 1 Receptor Deficiency in...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Sang › Cellules sanguines › Melanocortin 1 Receptor Deficiency in...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › Melanocortin 1 Receptor Deficiency in...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Melanocortin 1 Receptor Deficiency in...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Melanocortin 1 Receptor Deficiency in...
questionsmedicales.fr › Phénomènes physiologiques › Constitution physique › Prédisposition aux maladies › Melanocortin 1 Receptor Deficiency in...
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Tests immunologiques › Immunophénotypage › Melanocortin 1 Receptor Deficiency in...
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Melanocortin 1 Receptor Deficiency in...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Melanocortin 1 Receptor Deficiency in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Melanocortin 1 Receptor Deficiency in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Melanocortin 1 Receptor Deficiency in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur hormone hypophysaire › Récepteur corticotrophine › Récepteurs à la mélanocortine › Récepteur de la mélanocortine de type 1 › Melanocortin 1 Receptor Deficiency in...