Digenic Inheritance: Evidence and Gaps in Hemophagocytic Lymphohistiocytosis.
Animals
Cell Degranulation
/ genetics
Genetic Predisposition to Disease
Heredity
Humans
Killer Cells, Natural
/ immunology
Lymphohistiocytosis, Hemophagocytic
/ genetics
Multifactorial Inheritance
Mutation
Phenotype
Prognosis
Risk Factors
Secretory Vesicles
/ immunology
Signal Transduction
T-Lymphocytes, Cytotoxic
/ immunology
cytotoxic lymphocyte
degranulation
digenic
hemophagocytic lymphohistiocytosis
natural killer cell
variants
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
15
09
2021
accepted:
19
10
2021
entrez:
6
12
2021
pubmed:
7
12
2021
medline:
17
2
2022
Statut:
epublish
Résumé
Hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory disorder characterized by the inability to properly terminate an immune response. Familial HLH (FHLH) and related immune dysregulation syndromes are associated with mutations in the genes
Identifiants
pubmed: 34868048
doi: 10.3389/fimmu.2021.777851
pmc: PMC8635482
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
777851Subventions
Organisme : NIGMS NIH HHS
ID : T32 GM141323
Pays : United States
Informations de copyright
Copyright © 2021 Steen, Hermiston, Nichols and Meyer.
Déclaration de conflit d'intérêts
MH is a consultant for Novartis and Sobi. KN receives research funding from Incyte. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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