New Delhi Metallo-Beta-Lactamase Facilitates the Emergence of Cefiderocol Resistance in Enterobacter cloacae.
Enterobacter cloacae
Enterobacterales
New Delhi metallo-β-lactamase
antibiotic resistance
carbapenem resistance
cefiderocol
cefiderocol resistance
drug resistance mechanisms
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
15 02 2022
15 02 2022
Historique:
pubmed:
7
12
2021
medline:
23
3
2022
entrez:
6
12
2021
Statut:
ppublish
Résumé
Cefiderocol is a promising novel siderophore cephalosporin for the treatment of multidrug-resistant Gram-negative bacilli and with stability against degradation by metallo-β-lactamases. Nonetheless, the emergence of cefiderocol in metallo-β-lactamase-producing Enterobacterales during therapy has been reported on more than one occasion. To understand the underlying mechanisms and factors facilitating the resistance development, we conducted an
Identifiants
pubmed: 34871093
doi: 10.1128/AAC.02011-21
pmc: PMC8846454
doi:
Substances chimiques
Anti-Bacterial Agents
0
Cephalosporins
0
beta-Lactamases
EC 3.5.2.6
beta-lactamase NDM-1
EC 3.5.2.6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0201121Références
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