Capillary hemodynamics and contracting skeletal muscle oxygen pressures in male rats with heart failure: Impact of soluble guanylyl cyclase activator.


Journal

Nitric oxide : biology and chemistry
ISSN: 1089-8611
Titre abrégé: Nitric Oxide
Pays: United States
ID NLM: 9709307

Informations de publication

Date de publication:
01 02 2022
Historique:
received: 03 08 2021
revised: 21 10 2021
accepted: 02 12 2021
pubmed: 7 12 2021
medline: 26 2 2022
entrez: 6 12 2021
Statut: ppublish

Résumé

In heart failure with reduced ejection fraction (HFrEF), nitric oxide-soluble guanylyl cyclase (sGC) pathway dysfunction impairs skeletal muscle arteriolar vasodilation and thus capillary hemodynamics, contributing to impaired oxygen uptake (V̇O

Identifiants

pubmed: 34871799
pii: S1089-8603(21)00123-3
doi: 10.1016/j.niox.2021.12.001
pmc: PMC9469501
mid: NIHMS1831833
pii:
doi:

Substances chimiques

4-(((4-carboxybutyl) (2- (5-fluoro-2-((4'-(trifluoromethyl) biphenyl-4-yl)methoxy)phenyl)ethyl) amino)methyl)benzoic acid 0
Benzoates 0
Biphenyl Compounds 0
Hydrocarbons, Fluorinated 0
Soluble Guanylyl Cyclase EC 4.6.1.2
Oxygen S88TT14065

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1-8

Subventions

Organisme : NIGMS NIH HHS
ID : P20 GM113109
Pays : United States

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

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Auteurs

Ramona E Weber (RE)

Department of Kinesiology, Kansas State University, Manhattan, KS, USA. Electronic address: monaw@ksu.edu.

Kiana M Schulze (KM)

Department of Kinesiology, Kansas State University, Manhattan, KS, USA.

Trenton D Colburn (TD)

Department of Kinesiology, Kansas State University, Manhattan, KS, USA.

Andrew G Horn (AG)

Department of Kinesiology, Kansas State University, Manhattan, KS, USA.

K Sue Hageman (KS)

Department of Anatomy and Physiology, Kansas State University, Manhattan, KS, USA.

Carl J Ade (CJ)

Department of Kinesiology, Kansas State University, Manhattan, KS, USA.

Stephanie E Hall (SE)

Department of Anatomy and Physiology, Kansas State University, Manhattan, KS, USA.

Peter Sandner (P)

Bayer AG, Cardiology Research, Wuppertal, Germany and Hannover Medical School, Department of Pharmacology, Hannover, Germany.

Timothy I Musch (TI)

Department of Kinesiology, Kansas State University, Manhattan, KS, USA; Department of Anatomy and Physiology, Kansas State University, Manhattan, KS, USA.

David C Poole (DC)

Department of Kinesiology, Kansas State University, Manhattan, KS, USA; Department of Anatomy and Physiology, Kansas State University, Manhattan, KS, USA.

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Classifications MeSH