Viral evasion of the integrated stress response through antagonism of eIF2-P binding to eIF2B.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
07 12 2021
07 12 2021
Historique:
received:
11
06
2021
accepted:
17
09
2021
entrez:
8
12
2021
pubmed:
9
12
2021
medline:
30
12
2021
Statut:
epublish
Résumé
Viral infection triggers activation of the integrated stress response (ISR). In response to viral double-stranded RNA (dsRNA), RNA-activated protein kinase (PKR) phosphorylates the translation initiation factor eIF2, converting it from a translation initiator into a potent translation inhibitor and this restricts the synthesis of viral proteins. Phosphorylated eIF2 (eIF2-P) inhibits translation by binding to eIF2's dedicated, heterodecameric nucleotide exchange factor eIF2B and conformationally inactivating it. We show that the NSs protein of Sandfly Fever Sicilian virus (SFSV) allows the virus to evade the ISR. Mechanistically, NSs tightly binds to eIF2B (K
Identifiants
pubmed: 34876554
doi: 10.1038/s41467-021-26164-4
pii: 10.1038/s41467-021-26164-4
pmc: PMC8651678
doi:
Substances chimiques
Eukaryotic Initiation Factor-2
0
Eukaryotic Initiation Factor-2B
0
Viral Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7103Subventions
Organisme : NIH HHS
ID : S10 OD020054
Pays : United States
Organisme : NIH HHS
ID : S10 OD021741
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Informations de copyright
© 2021. The Author(s).
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