Preparation and evaluation of crocin loaded in nanoniosomes and their effects on ischemia-reperfusion injuries in rat kidney.
Animals
Antioxidants
/ metabolism
Blood Urea Nitrogen
Carotenoids
/ pharmacology
Creatinine
/ metabolism
Glutathione Peroxidase
/ metabolism
Kidney
/ drug effects
Kidney Diseases
/ drug therapy
Liposomes
/ administration & dosage
Male
Malondialdehyde
/ metabolism
Nanoparticles
/ administration & dosage
Oxidative Stress
/ drug effects
Protective Agents
/ pharmacology
Rats
Rats, Wistar
Renal Artery
/ drug effects
Reperfusion Injury
/ drug therapy
Superoxide Dismutase
/ metabolism
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
07 12 2021
07 12 2021
Historique:
received:
02
08
2021
accepted:
27
10
2021
entrez:
8
12
2021
pubmed:
9
12
2021
medline:
27
1
2022
Statut:
epublish
Résumé
As a powerful antioxidant compound, crocin can partially protect against renal ischemia/reperfusion (I/R) injuries. The encapsulation of components in niosomes (non-ionic surfactant-based vesicle) as nano-sized carrier systems has been proposed as they improve the solubility, stability, and bioavailability of drugs. Herein, the encapsulation of crocin in nano-niosomes and the effects of crocin-loaded nano-niosomes on renal ischemia/reperfusion-induced damages were evaluated. Nano-niosomes containing crocin were formulated by a modified heating method and were characterized for their physicochemical characteristics. Ischemia was induced by clamping the renal artery for 30 min followed by 1 or 24 h of reperfusion. Rats received an intra-arterial injection of nano-niosome-loaded crocin at the outset of reperfusion. Blood samples were taken after reperfusion to measure urea, creatinine (Cr), malondialdehyde (MDA), and superoxide dismutase (SOD) activity. The right kidney was removed for histological examination. The results showed that crocin-contain nano-niosomes have appropriate size and morphology, acceptable encapsulation efficiency, and a proper release pattern of crocin. I/R enhanced creatinine (Cr), urea, and malondialdehyde (MDA) serum levels and reduced SOD activity and histological damages in the renal tissue.
Identifiants
pubmed: 34876613
doi: 10.1038/s41598-021-02073-w
pii: 10.1038/s41598-021-02073-w
pmc: PMC8651637
doi:
Substances chimiques
Antioxidants
0
Liposomes
0
Protective Agents
0
Carotenoids
36-88-4
Malondialdehyde
4Y8F71G49Q
crocin
877GWI46C2
Creatinine
AYI8EX34EU
Glutathione Peroxidase
EC 1.11.1.9
Superoxide Dismutase
EC 1.15.1.1
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
23525Informations de copyright
© 2021. The Author(s).
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