The protective gene dose effect of the APOE ε2 allele on gray matter volume in cognitively unimpaired individuals.
Alzheimer's disease
Alzheimer's disease signature
apolipoprotein E ε2 carrier
brain maintenance
brain morphology
brain reserve
cognitive reserve
magnetic resonance
multi-site
resilience signature
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
revised:
23
06
2021
received:
30
03
2021
accepted:
01
09
2021
pubmed:
9
12
2021
medline:
20
7
2022
entrez:
8
12
2021
Statut:
ppublish
Résumé
Harboring two copies of the apolipoprotein E (APOE) ε2 allele strongly protects against Alzheimer's disease (AD). However, the effect of this genotype on gray matter (GM) volume in cognitively unimpaired individuals has not yet been described. Multicenter brain magnetic resonance images (MRIs) from cognitively unimpaired ε2 homozygotes were matched (1:1) against all other APOE genotypes for relevant confounders (n = 223). GM volumes of ε2 genotypic groups were compared to each other and to the reference group (APOE ε3/ε3). Carrying at least one ε2 allele was associated with larger GM volumes in brain areas typically affected by AD and also in areas associated with cognitive resilience. APOE ε2 homozygotes, but not APOE ε2 heterozygotes, showed larger GM volumes in areas related to successful aging. In addition to the known resistance against amyloid-β deposition, the larger GM volumes in key brain regions may confer APOE ε2 homozygotes additional protection against AD-related cognitive decline.
Identifiants
pubmed: 34877786
doi: 10.1002/alz.12487
pmc: PMC9542211
doi:
Substances chimiques
Apolipoprotein E2
0
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
1383-1395Subventions
Organisme : NIA NIH HHS
ID : U01 AG024904
Pays : United States
Organisme : Department of Health
Pays : United Kingdom
Informations de copyright
© 2021 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
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