A longitudinal investigation of Aβ, anxiety, depression, and mild cognitive impairment.
Pittsburgh compound B positron emission tomography
amyloid imaging
anxiety
depression
mild cognitive impairment
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
revised:
11
04
2021
received:
28
01
2021
accepted:
09
06
2021
pubmed:
9
12
2021
medline:
21
10
2022
entrez:
8
12
2021
Statut:
ppublish
Résumé
We investigated the longitudinal relationship between cortical amyloid deposition, anxiety, and depression and the risk of incident mild cognitive impairment (MCI). We followed 1440 community-dwelling, cognitively unimpaired individuals aged ≥ 50 years for a median of 5.5 years. Clinical anxiety and depression were assessed using Beck Anxiety and Depression Inventories (BAI, BDI-II). Cortical amyloid beta (Aβ) was measured by Pittsburgh compound B positron emission tomography (PiB-PET) and elevated deposition (PiB+) was defined as standardized uptake value ratio ≥ 1.48. We calculated Cox proportional hazards models with age as the time scale, adjusted for sex, education, and medical comorbidity. Cortical Aβ deposition (PiB+) independent of anxiety (BAI ≥ 10) or depression (BDI-II ≥ 13) increased the risk of MCI. There was a significant additive interaction between PiB+ and anxiety (joint effect hazard ratio 6.77; 95% confidence interval 3.58-12.79; P = .031) that is, being PiB+ and having anxiety further amplified the risk of MCI. Anxiety modified the association between PiB+ and incident MCI.
Identifiants
pubmed: 34877794
doi: 10.1002/alz.12504
pmc: PMC9174347
mid: NIHMS1746332
doi:
Substances chimiques
Amyloid beta-Peptides
0
Aniline Compounds
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1824-1831Subventions
Organisme : NIA NIH HHS
ID : R01 AG057708
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG006786
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG016574
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG034676
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG011378
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG041851
Pays : United States
Organisme : NIMH NIH HHS
ID : K01 MH068351
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS097495
Pays : United States
Informations de copyright
© 2021 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
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