Progression of Nigrostriatal Denervation in Cerebellar Multiple System Atrophy: A Prospective Study.

Cerebellum / diagnostic imaging Denervation Humans Multiple System Atrophy / diagnosis Prospective Studies Spinocerebellar Degenerations / diagnosis

Journal

Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060

Informations de publication

Date de publication:
08 02 2022
Historique:
received: 14 06 2021
accepted: 19 11 2021
pubmed: 10 12 2021
medline: 6 4 2022
entrez: 9 12 2021
Statut: ppublish

Résumé

Nigrostriatal dopaminergic denervation (NSDD) remains poorly characterized in cerebellar multiple system atrophy (MSA-C). We aimed to study NSDD progression in MSA-C and evaluate the capacity for [123I]-FP-CIT-SPECT and parkinsonism to differentiate MSA-C from idiopathic late-onset cerebellar ataxia (ILOCA). We included 85 patients successively referred for sporadic late-onset cerebellar ataxia (SLOCA). Every 6 months, SARA, UPDRS-III, and SDFS scores were measured, and MSA-C diagnostic criteria were searched for. Striatal/occipital dopaminergic binding ratio was evaluated every year with [123I]-FP-CIT-scintigraphy. After a mean follow-up of 33.8 months, 33 patients had probable MSA-C, 8 possible MSA-C, and 44 ILOCA. SARA and UPDRS-III scores worsened faster in the probable MSA-C group ( Rapid symptom worsening and NSDD existence and progression predict MSA-C among patients with SLOCA. Parkinsonism, NSDD, and dysautonomia should be considered equivalent for possible MSA-C diagnosis.

Identifiants

DOI: 10.1212/WNL.0000000000013172 PMID: 34880084
pubmed: 34880084
pii: WNL.0000000000013172
doi: 10.1212/WNL.0000000000013172
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

232-236

Commentaires et corrections

Type : CommentIn
Type : CommentIn

Informations de copyright

© 2021 American Academy of Neurology.

Auteurs

Thomas Wirth (T)

From the Neurology Department (T.W., A.V.I., O.G., S.M., T.B., L.R., C.T., M.A.), Strasbourg University Hospital, Strasbourg, France; Strasbourg Federation of Translational Medicine (FMTS) (T.W., C.T., M.A.), Strasbourg University, Strasbourg, France; INSERM-U964 (T.W., C.T., M.A.), CNRS-UMR7104, University of Strasbourg, Illkirch-Graffenstaden, France; Unit of Functional Neurosurgery (T.W.), National Hospital for Neurology and Neurosurgery, University College London Hospital, London, United-Kingdom; MNMS Platform (I.J.N., C.B.), University Hospitals of Strasbourg, Strasbourg, France; ICube (I.J.N., C.B., S.K.), University of Strasbourg / CNRS UMR 7357, Strasbourg, France; Department of Nuclear Medicine and Molecular Imaging (I.J.N., C.B.), ICANS, Strasbourg, France; Faculty of Medicine and School of Public Health (B.M.), Lumbumbashi University, Lubumbashi, Democratic Republic of Congo; Neurology Department (M.R.), Nancy Regional University Hospital, Nancy, France; Lorraine University (M.R.), Inserm U1256, NGERE, Nancy, France; and Imaging Department 2 (S.K.), Strasbourg University Hospital, Strasbourg, France. thomas.wirth@chru-strasbourg.fr.
ORCID: 0000-0002-4427-5765

Izzie Jacques Namer (IJ)

From the Neurology Department (T.W., A.V.I., O.G., S.M., T.B., L.R., C.T., M.A.), Strasbourg University Hospital, Strasbourg, France; Strasbourg Federation of Translational Medicine (FMTS) (T.W., C.T., M.A.), Strasbourg University, Strasbourg, France; INSERM-U964 (T.W., C.T., M.A.), CNRS-UMR7104, University of Strasbourg, Illkirch-Graffenstaden, France; Unit of Functional Neurosurgery (T.W.), National Hospital for Neurology and Neurosurgery, University College London Hospital, London, United-Kingdom; MNMS Platform (I.J.N., C.B.), University Hospitals of Strasbourg, Strasbourg, France; ICube (I.J.N., C.B., S.K.), University of Strasbourg / CNRS UMR 7357, Strasbourg, France; Department of Nuclear Medicine and Molecular Imaging (I.J.N., C.B.), ICANS, Strasbourg, France; Faculty of Medicine and School of Public Health (B.M.), Lumbumbashi University, Lubumbashi, Democratic Republic of Congo; Neurology Department (M.R.), Nancy Regional University Hospital, Nancy, France; Lorraine University (M.R.), Inserm U1256, NGERE, Nancy, France; and Imaging Department 2 (S.K.), Strasbourg University Hospital, Strasbourg, France.
ORCID: 0000-0003-1822-7759

Ben Monga (B)

From the Neurology Department (T.W., A.V.I., O.G., S.M., T.B., L.R., C.T., M.A.), Strasbourg University Hospital, Strasbourg, France; Strasbourg Federation of Translational Medicine (FMTS) (T.W., C.T., M.A.), Strasbourg University, Strasbourg, France; INSERM-U964 (T.W., C.T., M.A.), CNRS-UMR7104, University of Strasbourg, Illkirch-Graffenstaden, France; Unit of Functional Neurosurgery (T.W.), National Hospital for Neurology and Neurosurgery, University College London Hospital, London, United-Kingdom; MNMS Platform (I.J.N., C.B.), University Hospitals of Strasbourg, Strasbourg, France; ICube (I.J.N., C.B., S.K.), University of Strasbourg / CNRS UMR 7357, Strasbourg, France; Department of Nuclear Medicine and Molecular Imaging (I.J.N., C.B.), ICANS, Strasbourg, France; Faculty of Medicine and School of Public Health (B.M.), Lumbumbashi University, Lubumbashi, Democratic Republic of Congo; Neurology Department (M.R.), Nancy Regional University Hospital, Nancy, France; Lorraine University (M.R.), Inserm U1256, NGERE, Nancy, France; and Imaging Department 2 (S.K.), Strasbourg University Hospital, Strasbourg, France.

Caroline Bund (C)

From the Neurology Department (T.W., A.V.I., O.G., S.M., T.B., L.R., C.T., M.A.), Strasbourg University Hospital, Strasbourg, France; Strasbourg Federation of Translational Medicine (FMTS) (T.W., C.T., M.A.), Strasbourg University, Strasbourg, France; INSERM-U964 (T.W., C.T., M.A.), CNRS-UMR7104, University of Strasbourg, Illkirch-Graffenstaden, France; Unit of Functional Neurosurgery (T.W.), National Hospital for Neurology and Neurosurgery, University College London Hospital, London, United-Kingdom; MNMS Platform (I.J.N., C.B.), University Hospitals of Strasbourg, Strasbourg, France; ICube (I.J.N., C.B., S.K.), University of Strasbourg / CNRS UMR 7357, Strasbourg, France; Department of Nuclear Medicine and Molecular Imaging (I.J.N., C.B.), ICANS, Strasbourg, France; Faculty of Medicine and School of Public Health (B.M.), Lumbumbashi University, Lubumbashi, Democratic Republic of Congo; Neurology Department (M.R.), Nancy Regional University Hospital, Nancy, France; Lorraine University (M.R.), Inserm U1256, NGERE, Nancy, France; and Imaging Department 2 (S.K.), Strasbourg University Hospital, Strasbourg, France.
ORCID: 0000-0001-6916-858X

Andra Valentina Iosif (AV)

From the Neurology Department (T.W., A.V.I., O.G., S.M., T.B., L.R., C.T., M.A.), Strasbourg University Hospital, Strasbourg, France; Strasbourg Federation of Translational Medicine (FMTS) (T.W., C.T., M.A.), Strasbourg University, Strasbourg, France; INSERM-U964 (T.W., C.T., M.A.), CNRS-UMR7104, University of Strasbourg, Illkirch-Graffenstaden, France; Unit of Functional Neurosurgery (T.W.), National Hospital for Neurology and Neurosurgery, University College London Hospital, London, United-Kingdom; MNMS Platform (I.J.N., C.B.), University Hospitals of Strasbourg, Strasbourg, France; ICube (I.J.N., C.B., S.K.), University of Strasbourg / CNRS UMR 7357, Strasbourg, France; Department of Nuclear Medicine and Molecular Imaging (I.J.N., C.B.), ICANS, Strasbourg, France; Faculty of Medicine and School of Public Health (B.M.), Lumbumbashi University, Lubumbashi, Democratic Republic of Congo; Neurology Department (M.R.), Nancy Regional University Hospital, Nancy, France; Lorraine University (M.R.), Inserm U1256, NGERE, Nancy, France; and Imaging Department 2 (S.K.), Strasbourg University Hospital, Strasbourg, France.

Odile Gebus (O)

From the Neurology Department (T.W., A.V.I., O.G., S.M., T.B., L.R., C.T., M.A.), Strasbourg University Hospital, Strasbourg, France; Strasbourg Federation of Translational Medicine (FMTS) (T.W., C.T., M.A.), Strasbourg University, Strasbourg, France; INSERM-U964 (T.W., C.T., M.A.), CNRS-UMR7104, University of Strasbourg, Illkirch-Graffenstaden, France; Unit of Functional Neurosurgery (T.W.), National Hospital for Neurology and Neurosurgery, University College London Hospital, London, United-Kingdom; MNMS Platform (I.J.N., C.B.), University Hospitals of Strasbourg, Strasbourg, France; ICube (I.J.N., C.B., S.K.), University of Strasbourg / CNRS UMR 7357, Strasbourg, France; Department of Nuclear Medicine and Molecular Imaging (I.J.N., C.B.), ICANS, Strasbourg, France; Faculty of Medicine and School of Public Health (B.M.), Lumbumbashi University, Lubumbashi, Democratic Republic of Congo; Neurology Department (M.R.), Nancy Regional University Hospital, Nancy, France; Lorraine University (M.R.), Inserm U1256, NGERE, Nancy, France; and Imaging Department 2 (S.K.), Strasbourg University Hospital, Strasbourg, France.

Solveig Montaut (S)

From the Neurology Department (T.W., A.V.I., O.G., S.M., T.B., L.R., C.T., M.A.), Strasbourg University Hospital, Strasbourg, France; Strasbourg Federation of Translational Medicine (FMTS) (T.W., C.T., M.A.), Strasbourg University, Strasbourg, France; INSERM-U964 (T.W., C.T., M.A.), CNRS-UMR7104, University of Strasbourg, Illkirch-Graffenstaden, France; Unit of Functional Neurosurgery (T.W.), National Hospital for Neurology and Neurosurgery, University College London Hospital, London, United-Kingdom; MNMS Platform (I.J.N., C.B.), University Hospitals of Strasbourg, Strasbourg, France; ICube (I.J.N., C.B., S.K.), University of Strasbourg / CNRS UMR 7357, Strasbourg, France; Department of Nuclear Medicine and Molecular Imaging (I.J.N., C.B.), ICANS, Strasbourg, France; Faculty of Medicine and School of Public Health (B.M.), Lumbumbashi University, Lubumbashi, Democratic Republic of Congo; Neurology Department (M.R.), Nancy Regional University Hospital, Nancy, France; Lorraine University (M.R.), Inserm U1256, NGERE, Nancy, France; and Imaging Department 2 (S.K.), Strasbourg University Hospital, Strasbourg, France.

Thomas Bogdan (T)

From the Neurology Department (T.W., A.V.I., O.G., S.M., T.B., L.R., C.T., M.A.), Strasbourg University Hospital, Strasbourg, France; Strasbourg Federation of Translational Medicine (FMTS) (T.W., C.T., M.A.), Strasbourg University, Strasbourg, France; INSERM-U964 (T.W., C.T., M.A.), CNRS-UMR7104, University of Strasbourg, Illkirch-Graffenstaden, France; Unit of Functional Neurosurgery (T.W.), National Hospital for Neurology and Neurosurgery, University College London Hospital, London, United-Kingdom; MNMS Platform (I.J.N., C.B.), University Hospitals of Strasbourg, Strasbourg, France; ICube (I.J.N., C.B., S.K.), University of Strasbourg / CNRS UMR 7357, Strasbourg, France; Department of Nuclear Medicine and Molecular Imaging (I.J.N., C.B.), ICANS, Strasbourg, France; Faculty of Medicine and School of Public Health (B.M.), Lumbumbashi University, Lubumbashi, Democratic Republic of Congo; Neurology Department (M.R.), Nancy Regional University Hospital, Nancy, France; Lorraine University (M.R.), Inserm U1256, NGERE, Nancy, France; and Imaging Department 2 (S.K.), Strasbourg University Hospital, Strasbourg, France.

Laura Robelin (L)

From the Neurology Department (T.W., A.V.I., O.G., S.M., T.B., L.R., C.T., M.A.), Strasbourg University Hospital, Strasbourg, France; Strasbourg Federation of Translational Medicine (FMTS) (T.W., C.T., M.A.), Strasbourg University, Strasbourg, France; INSERM-U964 (T.W., C.T., M.A.), CNRS-UMR7104, University of Strasbourg, Illkirch-Graffenstaden, France; Unit of Functional Neurosurgery (T.W.), National Hospital for Neurology and Neurosurgery, University College London Hospital, London, United-Kingdom; MNMS Platform (I.J.N., C.B.), University Hospitals of Strasbourg, Strasbourg, France; ICube (I.J.N., C.B., S.K.), University of Strasbourg / CNRS UMR 7357, Strasbourg, France; Department of Nuclear Medicine and Molecular Imaging (I.J.N., C.B.), ICANS, Strasbourg, France; Faculty of Medicine and School of Public Health (B.M.), Lumbumbashi University, Lubumbashi, Democratic Republic of Congo; Neurology Department (M.R.), Nancy Regional University Hospital, Nancy, France; Lorraine University (M.R.), Inserm U1256, NGERE, Nancy, France; and Imaging Department 2 (S.K.), Strasbourg University Hospital, Strasbourg, France.

Mathilde Renaud (M)

From the Neurology Department (T.W., A.V.I., O.G., S.M., T.B., L.R., C.T., M.A.), Strasbourg University Hospital, Strasbourg, France; Strasbourg Federation of Translational Medicine (FMTS) (T.W., C.T., M.A.), Strasbourg University, Strasbourg, France; INSERM-U964 (T.W., C.T., M.A.), CNRS-UMR7104, University of Strasbourg, Illkirch-Graffenstaden, France; Unit of Functional Neurosurgery (T.W.), National Hospital for Neurology and Neurosurgery, University College London Hospital, London, United-Kingdom; MNMS Platform (I.J.N., C.B.), University Hospitals of Strasbourg, Strasbourg, France; ICube (I.J.N., C.B., S.K.), University of Strasbourg / CNRS UMR 7357, Strasbourg, France; Department of Nuclear Medicine and Molecular Imaging (I.J.N., C.B.), ICANS, Strasbourg, France; Faculty of Medicine and School of Public Health (B.M.), Lumbumbashi University, Lubumbashi, Democratic Republic of Congo; Neurology Department (M.R.), Nancy Regional University Hospital, Nancy, France; Lorraine University (M.R.), Inserm U1256, NGERE, Nancy, France; and Imaging Department 2 (S.K.), Strasbourg University Hospital, Strasbourg, France.

Stéphane Kremer (S)

From the Neurology Department (T.W., A.V.I., O.G., S.M., T.B., L.R., C.T., M.A.), Strasbourg University Hospital, Strasbourg, France; Strasbourg Federation of Translational Medicine (FMTS) (T.W., C.T., M.A.), Strasbourg University, Strasbourg, France; INSERM-U964 (T.W., C.T., M.A.), CNRS-UMR7104, University of Strasbourg, Illkirch-Graffenstaden, France; Unit of Functional Neurosurgery (T.W.), National Hospital for Neurology and Neurosurgery, University College London Hospital, London, United-Kingdom; MNMS Platform (I.J.N., C.B.), University Hospitals of Strasbourg, Strasbourg, France; ICube (I.J.N., C.B., S.K.), University of Strasbourg / CNRS UMR 7357, Strasbourg, France; Department of Nuclear Medicine and Molecular Imaging (I.J.N., C.B.), ICANS, Strasbourg, France; Faculty of Medicine and School of Public Health (B.M.), Lumbumbashi University, Lubumbashi, Democratic Republic of Congo; Neurology Department (M.R.), Nancy Regional University Hospital, Nancy, France; Lorraine University (M.R.), Inserm U1256, NGERE, Nancy, France; and Imaging Department 2 (S.K.), Strasbourg University Hospital, Strasbourg, France.

Christine Tranchant (C)

From the Neurology Department (T.W., A.V.I., O.G., S.M., T.B., L.R., C.T., M.A.), Strasbourg University Hospital, Strasbourg, France; Strasbourg Federation of Translational Medicine (FMTS) (T.W., C.T., M.A.), Strasbourg University, Strasbourg, France; INSERM-U964 (T.W., C.T., M.A.), CNRS-UMR7104, University of Strasbourg, Illkirch-Graffenstaden, France; Unit of Functional Neurosurgery (T.W.), National Hospital for Neurology and Neurosurgery, University College London Hospital, London, United-Kingdom; MNMS Platform (I.J.N., C.B.), University Hospitals of Strasbourg, Strasbourg, France; ICube (I.J.N., C.B., S.K.), University of Strasbourg / CNRS UMR 7357, Strasbourg, France; Department of Nuclear Medicine and Molecular Imaging (I.J.N., C.B.), ICANS, Strasbourg, France; Faculty of Medicine and School of Public Health (B.M.), Lumbumbashi University, Lubumbashi, Democratic Republic of Congo; Neurology Department (M.R.), Nancy Regional University Hospital, Nancy, France; Lorraine University (M.R.), Inserm U1256, NGERE, Nancy, France; and Imaging Department 2 (S.K.), Strasbourg University Hospital, Strasbourg, France.
ORCID: 0000-0002-2895-1292

Mathieu Anheim (M)

From the Neurology Department (T.W., A.V.I., O.G., S.M., T.B., L.R., C.T., M.A.), Strasbourg University Hospital, Strasbourg, France; Strasbourg Federation of Translational Medicine (FMTS) (T.W., C.T., M.A.), Strasbourg University, Strasbourg, France; INSERM-U964 (T.W., C.T., M.A.), CNRS-UMR7104, University of Strasbourg, Illkirch-Graffenstaden, France; Unit of Functional Neurosurgery (T.W.), National Hospital for Neurology and Neurosurgery, University College London Hospital, London, United-Kingdom; MNMS Platform (I.J.N., C.B.), University Hospitals of Strasbourg, Strasbourg, France; ICube (I.J.N., C.B., S.K.), University of Strasbourg / CNRS UMR 7357, Strasbourg, France; Department of Nuclear Medicine and Molecular Imaging (I.J.N., C.B.), ICANS, Strasbourg, France; Faculty of Medicine and School of Public Health (B.M.), Lumbumbashi University, Lubumbashi, Democratic Republic of Congo; Neurology Department (M.R.), Nancy Regional University Hospital, Nancy, France; Lorraine University (M.R.), Inserm U1256, NGERE, Nancy, France; and Imaging Department 2 (S.K.), Strasbourg University Hospital, Strasbourg, France.
ORCID: 0000-0001-8121-0605

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Classifications MeSH

questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Tronc cérébral › Rhombencéphale › Métencéphale › Cervelet › Progression of Nigrostriatal Denervation in...
questionsmedicales.fr › Procédures de chirurgie opératoire › Procédures de neurochirurgie › Dénervation › Progression of Nigrostriatal Denervation in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Progression of Nigrostriatal Denervation in...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Atrophie multisystématisée › Progression of Nigrostriatal Denervation in...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Progression of Nigrostriatal Denervation in...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Maladies génétiques congénitales › Maladies neurodégénératives héréditaires › Dégénérescences spinocérébelleuses › Progression of Nigrostriatal Denervation in...