Intracortical Somatosensory Stimulation to Elicit Fingertip Sensations in an Individual With Spinal Cord Injury.

Electric Stimulation / methods Hand Humans Somatosensory Cortex Spinal Cord Injuries Touch

Journal

Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060

Informations de publication

Date de publication:
15 Feb 2022
Historique:
received: 24 05 2021
accepted: 19 11 2021
pubmed: 10 12 2021
medline: 6 4 2022
entrez: 9 12 2021
Statut: ppublish

Résumé

The restoration of touch to fingers and fingertips is critical to achieving dexterous neuroprosthetic control for individuals with sensorimotor dysfunction. However, localized fingertip sensations have not been evoked via intracortical microstimulation (ICMS). Using a novel intraoperative mapping approach, we implanted electrode arrays in the finger areas of left and right somatosensory cortex and delivered ICMS over a 2-year period in a human participant with spinal cord injury. Stimulation evoked tactile sensations in 8 fingers, including fingertips, spanning both hands. Evoked percepts followed expected somatotopic arrangements. The subject was able to reliably identify up to 7 finger-specific sites spanning both hands in a finger discrimination task. The size of the evoked percepts was on average 33% larger than a finger pad, as assessed via manual markings of a hand image. The size of the evoked percepts increased modestly with increased stimulation intensity, growing 21% as pulse amplitude increased from 20 to 80 µA. Detection thresholds were estimated on a subset of electrodes, with estimates of 9.2 to 35 µA observed, roughly consistent with prior studies. These results suggest that ICMS can enable the delivery of consistent and localized fingertip sensations during object manipulation by neuroprostheses for individuals with somatosensory deficits. NCT03161067.

Sections du résumé

BACKGROUND AND OBJECTIVES OBJECTIVE
The restoration of touch to fingers and fingertips is critical to achieving dexterous neuroprosthetic control for individuals with sensorimotor dysfunction. However, localized fingertip sensations have not been evoked via intracortical microstimulation (ICMS).
METHODS METHODS
Using a novel intraoperative mapping approach, we implanted electrode arrays in the finger areas of left and right somatosensory cortex and delivered ICMS over a 2-year period in a human participant with spinal cord injury.
RESULTS RESULTS
Stimulation evoked tactile sensations in 8 fingers, including fingertips, spanning both hands. Evoked percepts followed expected somatotopic arrangements. The subject was able to reliably identify up to 7 finger-specific sites spanning both hands in a finger discrimination task. The size of the evoked percepts was on average 33% larger than a finger pad, as assessed via manual markings of a hand image. The size of the evoked percepts increased modestly with increased stimulation intensity, growing 21% as pulse amplitude increased from 20 to 80 µA. Detection thresholds were estimated on a subset of electrodes, with estimates of 9.2 to 35 µA observed, roughly consistent with prior studies.
DISCUSSION CONCLUSIONS
These results suggest that ICMS can enable the delivery of consistent and localized fingertip sensations during object manipulation by neuroprostheses for individuals with somatosensory deficits.
CLINICALTRIALSGOV IDENTIFIER BACKGROUND
NCT03161067.

Identifiants

DOI: 10.1212/WNL.0000000000013173 PMID: 34880087 PMC: PMC8865889
pubmed: 34880087
pii: WNL.0000000000013173
doi: 10.1212/WNL.0000000000013173
pmc: PMC8865889
doi:

Banques de données

ClinicalTrials.gov
['NCT03161067']

Types de publication

Clinical Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

e679-e687

Subventions

Organisme : NIBIB NIH HHS
ID : T32 EB003383
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

© 2021 American Academy of Neurology.

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Auteurs

Matthew S Fifer (MS)

From the Research and Exploratory Development Department (M.S.F., L.E.O., B.P.C., E.A.P., M.C.T., F.V.T.), Johns Hopkins University Applied Physics Laboratory, Laurel; National Institute of Mental Health (D.P.M.), NIH, Bethesda; Department of Biomedical Engineering (T.M.T., D.N.C.), Department of Physical Medicine and Rehabilitation (R.W.N., M.A.A., P.A.C., G.L.C.), Department of Neurosurgery (W.S.A.), and Department of Neurology (B.A.W., N.E.C.), Johns Hopkins University, Baltimore, MD; UMC Utrecht Brain Center (W.S., N.F.R.), the Netherlands; and Department of Organismal Biology and Anatomy (S.J.B.), University of Chicago, IL. matthew.fifer@jhuapl.edu.

David P McMullen (DP)

From the Research and Exploratory Development Department (M.S.F., L.E.O., B.P.C., E.A.P., M.C.T., F.V.T.), Johns Hopkins University Applied Physics Laboratory, Laurel; National Institute of Mental Health (D.P.M.), NIH, Bethesda; Department of Biomedical Engineering (T.M.T., D.N.C.), Department of Physical Medicine and Rehabilitation (R.W.N., M.A.A., P.A.C., G.L.C.), Department of Neurosurgery (W.S.A.), and Department of Neurology (B.A.W., N.E.C.), Johns Hopkins University, Baltimore, MD; UMC Utrecht Brain Center (W.S., N.F.R.), the Netherlands; and Department of Organismal Biology and Anatomy (S.J.B.), University of Chicago, IL.
ORCID: 0000-0003-0782-9068

Luke E Osborn (LE)

From the Research and Exploratory Development Department (M.S.F., L.E.O., B.P.C., E.A.P., M.C.T., F.V.T.), Johns Hopkins University Applied Physics Laboratory, Laurel; National Institute of Mental Health (D.P.M.), NIH, Bethesda; Department of Biomedical Engineering (T.M.T., D.N.C.), Department of Physical Medicine and Rehabilitation (R.W.N., M.A.A., P.A.C., G.L.C.), Department of Neurosurgery (W.S.A.), and Department of Neurology (B.A.W., N.E.C.), Johns Hopkins University, Baltimore, MD; UMC Utrecht Brain Center (W.S., N.F.R.), the Netherlands; and Department of Organismal Biology and Anatomy (S.J.B.), University of Chicago, IL.
ORCID: 0000-0003-2985-6294

Tessy M Thomas (TM)

From the Research and Exploratory Development Department (M.S.F., L.E.O., B.P.C., E.A.P., M.C.T., F.V.T.), Johns Hopkins University Applied Physics Laboratory, Laurel; National Institute of Mental Health (D.P.M.), NIH, Bethesda; Department of Biomedical Engineering (T.M.T., D.N.C.), Department of Physical Medicine and Rehabilitation (R.W.N., M.A.A., P.A.C., G.L.C.), Department of Neurosurgery (W.S.A.), and Department of Neurology (B.A.W., N.E.C.), Johns Hopkins University, Baltimore, MD; UMC Utrecht Brain Center (W.S., N.F.R.), the Netherlands; and Department of Organismal Biology and Anatomy (S.J.B.), University of Chicago, IL.
ORCID: 0000-0002-6408-8799

Breanne Christie (B)

From the Research and Exploratory Development Department (M.S.F., L.E.O., B.P.C., E.A.P., M.C.T., F.V.T.), Johns Hopkins University Applied Physics Laboratory, Laurel; National Institute of Mental Health (D.P.M.), NIH, Bethesda; Department of Biomedical Engineering (T.M.T., D.N.C.), Department of Physical Medicine and Rehabilitation (R.W.N., M.A.A., P.A.C., G.L.C.), Department of Neurosurgery (W.S.A.), and Department of Neurology (B.A.W., N.E.C.), Johns Hopkins University, Baltimore, MD; UMC Utrecht Brain Center (W.S., N.F.R.), the Netherlands; and Department of Organismal Biology and Anatomy (S.J.B.), University of Chicago, IL.
ORCID: 0000-0002-8397-0859

Robert W Nickl (RW)

From the Research and Exploratory Development Department (M.S.F., L.E.O., B.P.C., E.A.P., M.C.T., F.V.T.), Johns Hopkins University Applied Physics Laboratory, Laurel; National Institute of Mental Health (D.P.M.), NIH, Bethesda; Department of Biomedical Engineering (T.M.T., D.N.C.), Department of Physical Medicine and Rehabilitation (R.W.N., M.A.A., P.A.C., G.L.C.), Department of Neurosurgery (W.S.A.), and Department of Neurology (B.A.W., N.E.C.), Johns Hopkins University, Baltimore, MD; UMC Utrecht Brain Center (W.S., N.F.R.), the Netherlands; and Department of Organismal Biology and Anatomy (S.J.B.), University of Chicago, IL.

Daniel N Candrea (DN)

From the Research and Exploratory Development Department (M.S.F., L.E.O., B.P.C., E.A.P., M.C.T., F.V.T.), Johns Hopkins University Applied Physics Laboratory, Laurel; National Institute of Mental Health (D.P.M.), NIH, Bethesda; Department of Biomedical Engineering (T.M.T., D.N.C.), Department of Physical Medicine and Rehabilitation (R.W.N., M.A.A., P.A.C., G.L.C.), Department of Neurosurgery (W.S.A.), and Department of Neurology (B.A.W., N.E.C.), Johns Hopkins University, Baltimore, MD; UMC Utrecht Brain Center (W.S., N.F.R.), the Netherlands; and Department of Organismal Biology and Anatomy (S.J.B.), University of Chicago, IL.

Eric A Pohlmeyer (EA)

From the Research and Exploratory Development Department (M.S.F., L.E.O., B.P.C., E.A.P., M.C.T., F.V.T.), Johns Hopkins University Applied Physics Laboratory, Laurel; National Institute of Mental Health (D.P.M.), NIH, Bethesda; Department of Biomedical Engineering (T.M.T., D.N.C.), Department of Physical Medicine and Rehabilitation (R.W.N., M.A.A., P.A.C., G.L.C.), Department of Neurosurgery (W.S.A.), and Department of Neurology (B.A.W., N.E.C.), Johns Hopkins University, Baltimore, MD; UMC Utrecht Brain Center (W.S., N.F.R.), the Netherlands; and Department of Organismal Biology and Anatomy (S.J.B.), University of Chicago, IL.
ORCID: 0000-0001-8753-3296

Margaret C Thompson (MC)

From the Research and Exploratory Development Department (M.S.F., L.E.O., B.P.C., E.A.P., M.C.T., F.V.T.), Johns Hopkins University Applied Physics Laboratory, Laurel; National Institute of Mental Health (D.P.M.), NIH, Bethesda; Department of Biomedical Engineering (T.M.T., D.N.C.), Department of Physical Medicine and Rehabilitation (R.W.N., M.A.A., P.A.C., G.L.C.), Department of Neurosurgery (W.S.A.), and Department of Neurology (B.A.W., N.E.C.), Johns Hopkins University, Baltimore, MD; UMC Utrecht Brain Center (W.S., N.F.R.), the Netherlands; and Department of Organismal Biology and Anatomy (S.J.B.), University of Chicago, IL.

Manuel A Anaya (MA)

From the Research and Exploratory Development Department (M.S.F., L.E.O., B.P.C., E.A.P., M.C.T., F.V.T.), Johns Hopkins University Applied Physics Laboratory, Laurel; National Institute of Mental Health (D.P.M.), NIH, Bethesda; Department of Biomedical Engineering (T.M.T., D.N.C.), Department of Physical Medicine and Rehabilitation (R.W.N., M.A.A., P.A.C., G.L.C.), Department of Neurosurgery (W.S.A.), and Department of Neurology (B.A.W., N.E.C.), Johns Hopkins University, Baltimore, MD; UMC Utrecht Brain Center (W.S., N.F.R.), the Netherlands; and Department of Organismal Biology and Anatomy (S.J.B.), University of Chicago, IL.

Wouter Schellekens (W)

From the Research and Exploratory Development Department (M.S.F., L.E.O., B.P.C., E.A.P., M.C.T., F.V.T.), Johns Hopkins University Applied Physics Laboratory, Laurel; National Institute of Mental Health (D.P.M.), NIH, Bethesda; Department of Biomedical Engineering (T.M.T., D.N.C.), Department of Physical Medicine and Rehabilitation (R.W.N., M.A.A., P.A.C., G.L.C.), Department of Neurosurgery (W.S.A.), and Department of Neurology (B.A.W., N.E.C.), Johns Hopkins University, Baltimore, MD; UMC Utrecht Brain Center (W.S., N.F.R.), the Netherlands; and Department of Organismal Biology and Anatomy (S.J.B.), University of Chicago, IL.
ORCID: 0000-0001-5409-9665

Nick F Ramsey (NF)

From the Research and Exploratory Development Department (M.S.F., L.E.O., B.P.C., E.A.P., M.C.T., F.V.T.), Johns Hopkins University Applied Physics Laboratory, Laurel; National Institute of Mental Health (D.P.M.), NIH, Bethesda; Department of Biomedical Engineering (T.M.T., D.N.C.), Department of Physical Medicine and Rehabilitation (R.W.N., M.A.A., P.A.C., G.L.C.), Department of Neurosurgery (W.S.A.), and Department of Neurology (B.A.W., N.E.C.), Johns Hopkins University, Baltimore, MD; UMC Utrecht Brain Center (W.S., N.F.R.), the Netherlands; and Department of Organismal Biology and Anatomy (S.J.B.), University of Chicago, IL.
ORCID: 0000-0002-7136-259X

Sliman J Bensmaia (SJ)

From the Research and Exploratory Development Department (M.S.F., L.E.O., B.P.C., E.A.P., M.C.T., F.V.T.), Johns Hopkins University Applied Physics Laboratory, Laurel; National Institute of Mental Health (D.P.M.), NIH, Bethesda; Department of Biomedical Engineering (T.M.T., D.N.C.), Department of Physical Medicine and Rehabilitation (R.W.N., M.A.A., P.A.C., G.L.C.), Department of Neurosurgery (W.S.A.), and Department of Neurology (B.A.W., N.E.C.), Johns Hopkins University, Baltimore, MD; UMC Utrecht Brain Center (W.S., N.F.R.), the Netherlands; and Department of Organismal Biology and Anatomy (S.J.B.), University of Chicago, IL.
ORCID: 0000-0003-4039-9135

William S Anderson (WS)

From the Research and Exploratory Development Department (M.S.F., L.E.O., B.P.C., E.A.P., M.C.T., F.V.T.), Johns Hopkins University Applied Physics Laboratory, Laurel; National Institute of Mental Health (D.P.M.), NIH, Bethesda; Department of Biomedical Engineering (T.M.T., D.N.C.), Department of Physical Medicine and Rehabilitation (R.W.N., M.A.A., P.A.C., G.L.C.), Department of Neurosurgery (W.S.A.), and Department of Neurology (B.A.W., N.E.C.), Johns Hopkins University, Baltimore, MD; UMC Utrecht Brain Center (W.S., N.F.R.), the Netherlands; and Department of Organismal Biology and Anatomy (S.J.B.), University of Chicago, IL.

Brock A Wester (BA)

From the Research and Exploratory Development Department (M.S.F., L.E.O., B.P.C., E.A.P., M.C.T., F.V.T.), Johns Hopkins University Applied Physics Laboratory, Laurel; National Institute of Mental Health (D.P.M.), NIH, Bethesda; Department of Biomedical Engineering (T.M.T., D.N.C.), Department of Physical Medicine and Rehabilitation (R.W.N., M.A.A., P.A.C., G.L.C.), Department of Neurosurgery (W.S.A.), and Department of Neurology (B.A.W., N.E.C.), Johns Hopkins University, Baltimore, MD; UMC Utrecht Brain Center (W.S., N.F.R.), the Netherlands; and Department of Organismal Biology and Anatomy (S.J.B.), University of Chicago, IL.
ORCID: 0000-0002-1500-2143

Nathan E Crone (NE)

From the Research and Exploratory Development Department (M.S.F., L.E.O., B.P.C., E.A.P., M.C.T., F.V.T.), Johns Hopkins University Applied Physics Laboratory, Laurel; National Institute of Mental Health (D.P.M.), NIH, Bethesda; Department of Biomedical Engineering (T.M.T., D.N.C.), Department of Physical Medicine and Rehabilitation (R.W.N., M.A.A., P.A.C., G.L.C.), Department of Neurosurgery (W.S.A.), and Department of Neurology (B.A.W., N.E.C.), Johns Hopkins University, Baltimore, MD; UMC Utrecht Brain Center (W.S., N.F.R.), the Netherlands; and Department of Organismal Biology and Anatomy (S.J.B.), University of Chicago, IL.
ORCID: 0000-0001-7950-2617

Pablo A Celnik (PA)

From the Research and Exploratory Development Department (M.S.F., L.E.O., B.P.C., E.A.P., M.C.T., F.V.T.), Johns Hopkins University Applied Physics Laboratory, Laurel; National Institute of Mental Health (D.P.M.), NIH, Bethesda; Department of Biomedical Engineering (T.M.T., D.N.C.), Department of Physical Medicine and Rehabilitation (R.W.N., M.A.A., P.A.C., G.L.C.), Department of Neurosurgery (W.S.A.), and Department of Neurology (B.A.W., N.E.C.), Johns Hopkins University, Baltimore, MD; UMC Utrecht Brain Center (W.S., N.F.R.), the Netherlands; and Department of Organismal Biology and Anatomy (S.J.B.), University of Chicago, IL.

Gabriela L Cantarero (GL)

From the Research and Exploratory Development Department (M.S.F., L.E.O., B.P.C., E.A.P., M.C.T., F.V.T.), Johns Hopkins University Applied Physics Laboratory, Laurel; National Institute of Mental Health (D.P.M.), NIH, Bethesda; Department of Biomedical Engineering (T.M.T., D.N.C.), Department of Physical Medicine and Rehabilitation (R.W.N., M.A.A., P.A.C., G.L.C.), Department of Neurosurgery (W.S.A.), and Department of Neurology (B.A.W., N.E.C.), Johns Hopkins University, Baltimore, MD; UMC Utrecht Brain Center (W.S., N.F.R.), the Netherlands; and Department of Organismal Biology and Anatomy (S.J.B.), University of Chicago, IL.
ORCID: 0000-0001-7383-1743

Francesco V Tenore (FV)

From the Research and Exploratory Development Department (M.S.F., L.E.O., B.P.C., E.A.P., M.C.T., F.V.T.), Johns Hopkins University Applied Physics Laboratory, Laurel; National Institute of Mental Health (D.P.M.), NIH, Bethesda; Department of Biomedical Engineering (T.M.T., D.N.C.), Department of Physical Medicine and Rehabilitation (R.W.N., M.A.A., P.A.C., G.L.C.), Department of Neurosurgery (W.S.A.), and Department of Neurology (B.A.W., N.E.C.), Johns Hopkins University, Baltimore, MD; UMC Utrecht Brain Center (W.S., N.F.R.), the Netherlands; and Department of Organismal Biology and Anatomy (S.J.B.), University of Chicago, IL.
ORCID: 0000-0002-1197-9643

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Classifications MeSH

questionsmedicales.fr › Techniques d'investigation › Stimulation physique › Stimulation électrique › Intracortical Somatosensory Stimulation to...
questionsmedicales.fr › Régions du corps › Membres › Membre supérieur › Main › Intracortical Somatosensory Stimulation to...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Intracortical Somatosensory Stimulation to...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Cortex sensorimoteur › Cortex somatosensoriel › Intracortical Somatosensory Stimulation to...
questionsmedicales.fr › Plaies et blessures › Traumatismes de la moelle épinière › Intracortical Somatosensory Stimulation to...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Sensation › Toucher › Intracortical Somatosensory Stimulation to...