Lymphocyte-activation gene 3 in non-small-cell lung carcinomas: correlations with clinicopathologic features and prognostic significance.
Adenocarcinoma
/ pathology
Antigens, CD
/ genetics
B7-H1 Antigen
CD8-Positive T-Lymphocytes
/ pathology
Carcinoma, Non-Small-Cell Lung
/ pathology
Carcinoma, Squamous Cell
/ pathology
Humans
Lung Neoplasms
/ pathology
Lymphocytes, Tumor-Infiltrating
Prognosis
Tumor Microenvironment
Lymphocyte Activation Gene 3 Protein
Journal
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
ISSN: 1530-0285
Titre abrégé: Mod Pathol
Pays: United States
ID NLM: 8806605
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
received:
29
03
2021
accepted:
11
11
2021
pubmed:
10
12
2021
medline:
29
4
2022
entrez:
9
12
2021
Statut:
ppublish
Résumé
Lymphocyte-activation gene 3 (LAG-3) modulates the tumor microenvironment through immunosuppressive effects. Its associations with clinicopathologic parameters and prognostic significance in non-small-cell lung carcinomas remain unclear. We examined LAG-3 expression in 368 resected non-small-cell lung carcinomas (including 218 adenocarcinomas and 150 squamous-cell carcinomas) using tissue microarrays, with normalization to CD8
Identifiants
pubmed: 34880448
doi: 10.1038/s41379-021-00974-9
pii: S0893-3952(22)00113-2
pmc: PMC9050756
mid: NIHMS1764707
doi:
Substances chimiques
Antigens, CD
0
B7-H1 Antigen
0
Lymphocyte Activation Gene 3 Protein
0
Lag3 protein, human
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
615-624Subventions
Organisme : NCI NIH HHS
ID : R01 CA240317
Pays : United States
Informations de copyright
© 2021. The Author(s), under exclusive licence to United States & Canadian Academy of Pathology.
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