'Moderate global aphasia': A generalized decline of language processing caused by glioma surgery but not stroke.
Aphasia
Glioma
K-means clustering
Neurosurgery
Stroke
Journal
Brain and language
ISSN: 1090-2155
Titre abrégé: Brain Lang
Pays: Netherlands
ID NLM: 7506220
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
received:
01
05
2021
revised:
15
10
2021
accepted:
24
11
2021
pubmed:
10
12
2021
medline:
26
4
2022
entrez:
9
12
2021
Statut:
ppublish
Résumé
Unlike stroke, neurosurgical removal of left-hemisphere gliomas acts upon a reorganized language network and involves brain areas rarely damaged by stroke. We addressed whether this causes the profiles of neurosurgery- and stroke-induced language impairments to be distinct. K-means clustering of language assessment data (neurosurgery cohort: N = 88, stroke cohort: N = 95) identified similar profiles in both cohorts. But critically, a cluster of individuals with specific phonological deficits was only evident in the stroke but not in the neurosurgery cohort. Thus, phonological deficits are less clearly distinguished from other language deficits after glioma surgery compared to stroke. Furthermore, the correlations between language production and comprehension scores at different linguistic levels were more extensive in the neurosurgery than in the stroke cohort. Our findings suggest that neurosurgery-induced language impairments do not correspond to those caused by stroke, but rather manifest as a 'moderate global aphasia' - a generalized decline of language processing abilities.
Identifiants
pubmed: 34883333
pii: S0093-934X(21)00151-6
doi: 10.1016/j.bandl.2021.105057
pmc: PMC8743859
mid: NIHMS1763949
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
105057Subventions
Organisme : NIDCD NIH HHS
ID : R01 DC016345
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
Références
J Neurol Neurosurg Psychiatry. 2003 Jul;74(7):901-7
pubmed: 12810776
Cereb Cortex. 2009 Apr;19(4):832-8
pubmed: 18678765
Lancet. 1998 Apr 4;351(9108):1014-8
pubmed: 9546507
Cortex. 2013 Mar;49(3):611-25
pubmed: 23260615
J Neurooncol. 2016 Jun;128(2):323-31
pubmed: 27022915
J Cogn Neurosci. 2020 Aug;32(8):1497-1507
pubmed: 32286133
Brain Lang. 2017 Nov;174:86-93
pubmed: 28803212
Stroke. 2015 Sep;46(9):2438-44
pubmed: 26199314
Nat Rev Neurosci. 2007 May;8(5):393-402
pubmed: 17431404
Brain. 2009 Jan;132(Pt 1):87-102
pubmed: 19050031
Acta Neurochir (Wien). 2013 Apr;155(4):685-92
pubmed: 23440372
Neuroimage. 2002 Jan;15(1):273-89
pubmed: 11771995
Neuroimage. 2012 Jul 16;61(4):957-65
pubmed: 22440645
J Neurooncol. 1995;23(3):265-70
pubmed: 7673991
Cerebrovasc Dis. 2004;17(1):35-43
pubmed: 14530636
Lancet Neurol. 2005 Aug;4(8):476-86
pubmed: 16033690
Neuroimage Clin. 2018;20:1129-1138
pubmed: 30380520
N Engl J Med. 2008 Jan 3;358(1):18-27
pubmed: 18172171
Neurology. 2001 Sep 11;57(5):871-8
pubmed: 11552019
J Neurosci. 2016 Jun 22;36(25):6668-79
pubmed: 27335399
Arch Neurol. 1990 Apr;47(4):397-405
pubmed: 2322133
PLoS One. 2021 Nov 18;16(11):e0258946
pubmed: 34793469
J Neurosurg. 2008 Oct;109(4):583-92
pubmed: 18826344
Neuroimage Clin. 2018 Mar 30;19:22-29
pubmed: 30034998
J Neurosurg. 2015 Sep;123(3):581-93
pubmed: 26115463
J Neurosurg. 2008 Sep;109(3):461-71
pubmed: 18759577
Neuroimage. 2006 Jul 1;31(3):1116-28
pubmed: 16545965
Aphasiology. 2017;31(11):1266-1281
pubmed: 29056810