Prenatal Exposure to Triclocarban Impairs ESR1 Signaling and Disrupts Epigenetic Status in Sex-Specific Ways as Well as Dysregulates the Expression of Neurogenesis- and Neurotransmitter-Related Genes in the Postnatal Mouse Brain.
Animals
Anti-Infective Agents, Local
/ toxicity
Blood-Brain Barrier
/ drug effects
Brain
/ drug effects
Carbanilides
/ toxicity
DNA Methylation
/ drug effects
Epigenesis, Genetic
/ drug effects
Estrogen Receptor alpha
/ metabolism
Female
Gene Expression Regulation
/ drug effects
Male
Mice
Neurogenesis
/ drug effects
Neurotransmitter Agents
/ genetics
Pregnancy
Prenatal Exposure Delayed Effects
Sex Factors
Signal Transduction
/ drug effects
DNA methylation
environmentally pervasive chemicals
estrogen receptors
microarrays
xenobiotic receptors
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
04 Dec 2021
04 Dec 2021
Historique:
received:
19
10
2021
revised:
30
11
2021
accepted:
01
12
2021
entrez:
10
12
2021
pubmed:
11
12
2021
medline:
8
1
2022
Statut:
epublish
Résumé
Triclocarban is a highly effective and broadly used antimicrobial agent. Humans are continually exposed to triclocarban, but the safety of prenatal exposure to triclocarban in the context of neurodevelopment remains unknown. In this study, we demonstrated for the first time that mice that had been prenatally exposed to environmentally relevant doses of triclocarban had impaired estrogen receptor 1 (ESR1) signaling in the brain. These mice displayed decreased mRNA and protein expression levels of ESR1 as well as hypermethylation of the
Identifiants
pubmed: 34884933
pii: ijms222313121
doi: 10.3390/ijms222313121
pmc: PMC8658534
pii:
doi:
Substances chimiques
Anti-Infective Agents, Local
0
Carbanilides
0
Esr1 protein, mouse
0
Estrogen Receptor alpha
0
Neurotransmitter Agents
0
triclocarban
BGG1Y1ED0Y
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Science Center
ID : 2015/19/B/NZ7/02449
Organisme : the statutory fund of the Maj Institute of Pharmacology at the Polish Academy of Sciences in Krakow, Poland
ID : N/A
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