Amine- and Amino Acid-Based Compounds as Carbonic Anhydrase Activators.
activators
amine
amino acid
carbonic anhydrase
coral
fungi
isoform selectivity
learning and cognitive impairment
neurodegenerative diseases
protozoa
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
02 Dec 2021
02 Dec 2021
Historique:
received:
27
10
2021
revised:
26
11
2021
accepted:
01
12
2021
entrez:
10
12
2021
pubmed:
11
12
2021
medline:
9
2
2022
Statut:
epublish
Résumé
After being rather neglected as a research field in the past, carbonic anhydrase activators (CAAs) were undoubtedly demonstrated to be useful in diverse pharmaceutical and industrial applications. They also improved the knowledge of the requirements to selectively interact with a CA isoform over the others and confirmed the catalytic mechanism of this class of compounds. Amino acid and amine derivatives were the most explored in in vitro, in vivo and crystallographic studies as CAAs. Most of them were able to activate human or non-human CA isoforms in the nanomolar range, being proposed as therapeutic and industrial tools. Some isoforms are better activated by amino acids than amines derivatives and the stereochemistry may exert a role. Finally, non-human CAs have been very recently tested for activation studies, paving the way to innovative industrial and environmental applications.
Identifiants
pubmed: 34885917
pii: molecules26237331
doi: 10.3390/molecules26237331
pmc: PMC8659172
pii:
doi:
Substances chimiques
Amines
0
Amino Acids
0
Enzyme Activators
0
Protein Isoforms
0
Carbonic Anhydrases
EC 4.2.1.1
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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