5-Methyltetrahydrofolate and Vitamin B12 Supplementation Is Associated with Clinical Pregnancy and Live Birth in Women Undergoing Assisted Reproductive Technology.
MTHFR
assisted reproduction
dietary supplement
folate
pregnancy
vitamin B complex
Journal
International journal of environmental research and public health
ISSN: 1660-4601
Titre abrégé: Int J Environ Res Public Health
Pays: Switzerland
ID NLM: 101238455
Informations de publication
Date de publication:
23 11 2021
23 11 2021
Historique:
received:
08
10
2021
revised:
10
11
2021
accepted:
21
11
2021
entrez:
10
12
2021
pubmed:
11
12
2021
medline:
31
12
2021
Statut:
epublish
Résumé
The homocysteine pathway in the preconception period should be evaluated to highlight micronutrient deficiencies and warrants optimal multivitamin supplementation, before Assisted Reproduction, as preconception care. We conducted a retrospective study aimed at investigating the role of vitamin B complex (5-methyltetrahydrofolate, vitamin B12, vitamin B6) supplement use compared with the role of only folic acid supplement use, in relation to clinical pregnancy and live birth in infertile women undergoing homologous ART. We investigated 269 Caucasian women referred to the Centre for Assisted Reproductive Technology for homologous ART. In these women, 111 (Group A) were daily supplemented with vitamin B complex and 158 (Group B) with only folic acid. In group A the mean number of Metaphase II oocytes and the 2PN Fertilization Rate were higher in comparison to group A (
Identifiants
pubmed: 34886014
pii: ijerph182312280
doi: 10.3390/ijerph182312280
pmc: PMC8657301
pii:
doi:
Substances chimiques
Tetrahydrofolates
0
Homocysteine
0LVT1QZ0BA
Vitamin B Complex
12001-76-2
Folic Acid
935E97BOY8
Vitamin B 12
P6YC3EG204
5-methyltetrahydrofolate
TYK22LML8F
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
Cephalalgia. 2018 Jan;38(1):1-211
pubmed: 29368949
J Obstet Gynaecol Can. 2021 Jan;43(1):124-139.e8
pubmed: 33212246
Hum Reprod. 2006 Jul;21(7):1725-33
pubmed: 16556671
Hum Reprod. 2000 Apr;15(4):954-60
pubmed: 10739849
J Hypertens. 2020 Jun;38(6):982-1004
pubmed: 32371787
Nutrients. 2016 Nov 29;8(12):
pubmed: 27916823
Fertil Steril. 2010 Nov;94(6):2096-101
pubmed: 20189169
Hum Reprod Open. 2018 Apr 06;2018(2):hoy004
pubmed: 31486805
Eur J Contracept Reprod Health Care. 2017 Feb;22(1):70-75
pubmed: 27976929
Hum Reprod. 2009 May;24(5):1059-66
pubmed: 19221098
Reprod Toxicol. 2018 Mar;76:12-16
pubmed: 29253588
Hum Reprod Update. 2007 Mar-Apr;13(2):163-74
pubmed: 17099205
Hum Reprod. 2005 Aug;20(8):2237-41
pubmed: 15831504
Reprod Biomed Online. 2014 Jun;28(6):766-72
pubmed: 24745837
Eur Heart J. 2020 Jan 1;41(1):111-188
pubmed: 31504418
Int J Epidemiol. 2009 Jun;38(3):715-23
pubmed: 19336437
Nutr Metab Cardiovasc Dis. 2013 May;23(5):473-80
pubmed: 22209740
Toxicol In Vitro. 1993 Nov;7(6):743-9
pubmed: 20732275
Acta Obstet Gynecol Scand. 2015 Jan;94(1):65-71
pubmed: 25283235
Reprod Biomed Online. 2017 Nov;35(5):494-510
pubmed: 28784335
Reprod Med Biol. 2020 Oct 25;20(1):76-82
pubmed: 33488286
Am J Clin Nutr. 2015 Oct;102(4):943-50
pubmed: 26354529
Reprod Toxicol. 2017 Sep;72:159-163
pubmed: 28689805
J Nutr. 2006 Jun;136(6 Suppl):1731S-1740S
pubmed: 16702348
J Intern Med. 2021 Jan;289(1):2-11
pubmed: 32592243
Hum Reprod. 2009 Sep;24(9):2293-302
pubmed: 19443458
Reprod Biol Endocrinol. 2018 Dec 5;16(1):121
pubmed: 30518389
Hum Reprod Update. 2007 May-Jun;13(3):225-38
pubmed: 17307774
J Obstet Gynaecol. 1998 Mar;18(2):192-3
pubmed: 15512051
Lancet. 1967 Dec 16;2(7529):1305
pubmed: 4168627
Lancet. 2006 May 6;367(9521):1513-9
pubmed: 16679164