Comparison of thyroid-stimulating hormone levels in adolescents with schizophrenia, bipolar disorder, unipolar depression, conduct disorders, and hyperkinetic disorders.
Journal
Medicine
ISSN: 1536-5964
Titre abrégé: Medicine (Baltimore)
Pays: United States
ID NLM: 2985248R
Informations de publication
Date de publication:
10 Dec 2021
10 Dec 2021
Historique:
received:
21
04
2021
accepted:
18
11
2021
entrez:
10
12
2021
pubmed:
11
12
2021
medline:
8
2
2022
Statut:
ppublish
Résumé
The aim of this study was to retrospectively compare values of thyroid-stimulating hormone (TSH) in adolescent patients diagnosed with schizophrenia, bipolar disorder, unipolar depression (UNI-DEP), conduct disorders (CD), and hyperkinetic disorders.The research involved 1122 patients (718 women, 64%); aged 12 to 18 hospitalized in the Department of Adolescent Psychiatry, Medical University of Lodz. We analyzed TSH levels in the whole study population and compared it between the above-mentioned subgroups of diagnoses.Mean serum TSH concentration in the studied population (n = 1122) was 2.06 μIU/mL. The values of percentiles were as follows: 2.5th - 0.53 μIU/mL, 10th - 0.89 μIU/mL, 25th - 1.31 μIU/mL, 50th - 1.9 μIU/mL, 75th - 2.6 μIU/mL, 90th - 3.43 μIU/mL, 97.5th - 4.72 μIU/mL. TSH values were negatively correlated with patients' age (P = .00001). Patients with bipolar depression had higher TSH levels than patients with CD (P = .002). Also, when male and female groups were examined separately we found that female patients with UNI-DEP and bipolar disorder had higher TSH levels than female patients with CD (P = .001; P = .001).Our results confirm that there may be a higher prevalence of thyroid dysfunctions in bipolar and UNI-DEP subgroups among adolescents and that it is worthy to consider some kind of interventions regarding thyroid function in depressed individuals.
Identifiants
pubmed: 34889284
doi: 10.1097/MD.0000000000028160
pii: 00005792-202112100-00065
pmc: PMC8663859
doi:
Substances chimiques
Biomarkers
0
Thyrotropin
9002-71-5
Lithium
9FN79X2M3F
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e28160Informations de copyright
Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.
Déclaration de conflit d'intérêts
The authors have no funding and conflicts of interest to disclose.
Références
Merikangas KR, Nakamura EF, Kessler RC. Epidemiology of mental disorders in children and adolescents. Dialogues Clin Neurosci 2009;11:07–20.
Michaud P-A, Fombonne E. Common mental health problems. BMJ 2005;330:835–8.
Costello EJ, Mustillo S, Erkanli A, et al. Prevalence and development of psychiatric disorders in childhood and adolescence. Arch Gen Psychiatry 2003;60:837–44.
Ford T, Goodman R, Meltzer H. The British child and adolescent mental health survey 1999: the prevalence of DSM-IV disorders. J Am Acad Child Adolesc Psychiatry 2003;42:1203–11.
Kessler RC, Amminger GP, Aguilar-Gaxiola S, et al. Age of onset of mental disorders: a review of recent literature. Curr Opin Psychiatry 2007;20:359–64.
Larsen PR, Silva JE, Kaplan MM. Relationships between circulating and intracellular thyroid hormones: physiological and clinical implications. Endocr Rev 1981;2:87–102.
Bettendorf M. Thyroid disorders in children from birth to adolescence. Eur J Nucl Med Mol Imaging 2002;29(S2):S439–46.
Hanna CE, LaFranchi SH. Adolescent thyroid disorders. Adolesc Med Phila Pa 2002;13:13–35.
de Vries L, Bulvik S, Phillip M. Chronic autoimmune thyroiditis in children and adolescents: at presentation and during long-term follow-up. Arch Dis Child 2009;94:33–7.
Hanley P, Lord K, Bauer AJ. Thyroid disorders in children and adolescents: a review. JAMA Pediatr 2016;170:1008–19.
Lavard L, Ranløv I, Perrild H, et al. Incidence of juvenile thyrotoxicosis in Denmark: a nationwide study. Eur J Endocrinol 1994;130:565–8.
Williamson S, Greene SA. Incidence of thyrotoxicosis in childhood: a national population based study in the UK and Ireland. Clin Endocrinol (Oxf) 2010;72:358–63.
Kapelari K, Kirchlechner C, Högler W, et al. Pediatric reference intervals for thyroid hormone levels from birth to adulthood: a retrospective study. BMC Endocr Disord 2008;08–15. doi: 10.1186/1472-6823-8-15.
doi: 10.1186/1472-6823-8-15
Kathol RG, Delahunt JW. The relationship of anxiety and depression to symptoms of hyperthyroidism using operational criteria. Gen Hosp Psychiatry 1986;8:23–8.
Snabboon T, Khemkha A, Chaiyaumporn C, et al. Psychosis as the first presentation of hyperthyroidism. Intern Emerg Med 2009;4:359–60.
Hu L-Y, Shen C-C, Hu Y-W. Kato T, et al. Hyperthyroidism and risk for bipolar disorders: a nationwide population-based study. PLoS One 2013;8:e73057.
Wysokiński A, Kłoszewska I. Level of thyroid-stimulating hormone (TSH) in patients with acute schizophrenia, unipolar depression or bipolar disorder. Neurochem Res 2014;39:1245–53.
Hage MP, Azar ST. The link between thyroid function and depression. J Thyroid Res 2012;2012:01–8.
Barbuti M, Carvalho AF, Köhler CA, et al. Thyroid autoimmunity in bipolar disorder: a systematic review. J Affect Disord 2017;221:97–106.
Chueire VB, Romaldini JH, Ward LS. Subclinical hypothyroidism increases the risk for depression in the elderly. Arch Gerontol Geriatr 2007;44:21–8.
Raza SA, Mahmood N. Subclinical hypothyroidism: controversies to consensus. Indian J Endocrinol Metab 2013;17: (Suppl 3): S636–42.
Garber J, Cobin R, Gharib H, et al. Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. Endocr Pract 2012;18:988–1028.
Kratzsch J, Fiedler GM, Leichtle A, et al. New reference intervals for thyrotropin and thyroid hormones based on National Academy of Clinical Biochemistry Criteria and Regular Ultrasonography of the Thyroid. Clin Chem 2005;51:1480–6.
Placidi GPA, Boldrini M, Patronelli A, et al. Prevalence of psychiatric disorders in thyroid diseased patients. Neuropsychobiology 1998;38:222–5.
Holtmann M, Duketis E, Goth K, et al. Severe affective and behavioral dysregulation in youth is associated with increased serum TSH. J Affect Disord 2010;121:184–8.
Zepf FD, Vloet TD, Polier GG, et al. No association between affective and behavioral dysregulation and parameters of thyroid function in youths. J Affect Disord 2011;134:478–82.
Özerdem A, Tunca Z, Çimrin D, et al. Female vulnerability for thyroid function abnormality in bipolar disorder: role of lithium treatment. Bipolar Disord 2014;16:72–82.
Oron T, Lazar L, Feldhamer I, et al. Pediatric reference values of TSH should be personalized according to BMI and ethnicity. Eur J Endocrinol 2020;183:419–26.
Hollowell JG, Staehling NW, Flanders WD, et al. Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab 2002;87:489–99.
Kamble MT, Nandedkar PD, Dharme PV, et al. Thyroid function and mental disorders: an insight into the complex interaction. J Clin Diagn Res JCDR 2013;7:11–4.
Kim J, Carlson GA, Meyer SE, et al. Correlates of the CBCL-dysregulation profile in preschool-aged children. J Child Psychol Psychiatry 2012;53:918–26.
Mick E, Biederman J, Pandina G, et al. A preliminary meta-analysis of the child behavior checklist in pediatric bipolar disorder. Biol Psychiatry 2003;53:1021–7.
Biederman J, Wozniak J, Kiely K, et al. CBCL clinical scales discriminate prepubertal children with structured interview—derived diagnosis of mania from those with ADHD. J Am Acad Child Adolesc Psychiatry 1995;34:464–71.
Biederman J, Petty CR, Monuteaux MC, et al. The child behavior checklist-pediatric bipolar disorder profile predicts a subsequent diagnosis of bipolar disorder and associated impairments in ADHD youth growing up. J Clin Psychiatry 2009;70:732–40.
Volk HE, Todd RD. Does the child behavior checklist juvenile bipolar disorder phenotype identify bipolar disorder? Biol Psychiatry 2007;62:115–20.
McGough JJ, Loo SK, McCracken JT, et al. CBCL pediatric bipolar disorder profile and ADHD: comorbidity and quantitative trait loci analysis. J Am Acad Child Adolesc Psychiatry 2008;47:1151–7.
Manji HK, Quiroz JA, Payne JL, et al. The underlying neurobiology of bipolar disorder. World Psychiatry Off J World Psychiatr Assoc WPA 2003;2:136–46.
Hatterer JA, Herbert J, Hidaka C, et al. CSF transthyretin in patients with depression. Am J Psychiatry 1993;150:813–5.
Hennemann G, Docter R, Friesema ECH, et al. Plasma membrane transport of thyroid hormones and its role in thyroid hormone metabolism and bioavailability. Endocr Rev 2001;22:451–76.
Radhakrishnan R, Calvin S, Singh JK, et al. Thyroid dysfunction in major psychiatric disorders in a hospital based sample. Indian J Med Res 2013;138:888–93.
Heinrich TW, Grahm G. Hypothyroidism presenting as psychosis. Prim Care Companion J Clin Psychiatry 2003;05:260–6.
Jucevičiute N, Žilaitiene B, Aniuliene R, et al. The link between thyroid autoimmunity, depression and bipolar disorder. Open Med (Poland) De Gruyter 2019;14:52–8.
Elsevier, Raison CL, Rook GW, Miller AH, et al. Role of inflammation in psychiatric disease. Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders 2015;396–421.
Muneer A. Bipolar disorder: role of inflammation and the development of disease biomarkers. Psychiatry Investig 2016;13:18–33.
Gama CS, Kunz M, Magalhães PVS, et al. Staging and neuroprogression in bipolar disorder: a systematic review of the literature. Rev Bras Psiquiatr Sao Paulo Braz 1999 2013;35:70–4.
Bindra A, Braunstein GD. Thyroiditis. Am Fam Physician 2006;73:1769–76.
Singer PA. Thyroiditis. Acute, subacute, and chronic. Med Clin North Am 1991;75:61–77.
Eker SS, Akkaya C, Sarandol A, et al. Effects of various antidepressants on serum thyroid hormone levels in patients with major depressive disorder. Prog Neuropsychopharmacol Biol Psychiatry 2008;32:955–61.
Magliozzi JR, Mungas D, Laubly JN, et al. Effect of haloperidol on a symbol digit substitution task in normal adult males. Neuropsychopharmacol Off Publ Am Coll Neuropsychopharmacol 1989;2:29–37.