Keratin 1 as a cell-surface receptor in cancer.
Cancer cells
Cell-Surface Keratin 1
Drug/diagnostic target
Intermediate filament
Keratin 1
Keratins
Journal
Biochimica et biophysica acta. Reviews on cancer
ISSN: 1879-2561
Titre abrégé: Biochim Biophys Acta Rev Cancer
Pays: Netherlands
ID NLM: 9806362
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
received:
19
08
2021
revised:
10
11
2021
accepted:
30
11
2021
pubmed:
11
12
2021
medline:
26
4
2022
entrez:
10
12
2021
Statut:
ppublish
Résumé
Keratins are fibrous proteins that take part in several important cellular functions, including the formation of intermediate filaments. In addition, keratins serve as epithelial cell markers, which has made their role in cancer progression, diagnosis, and treatment an important focus of research. Keratin 1 (K1) is a type II keratin whose structure is comprised of a coiled-coil central domain flanked by flexible, glycine-rich loops in the N- and C-termini. While the structure of cytoplasmic K1 is established, the structure of cell-surface K1 is not known. Several transformed cells, such as cancerous cells and cells that have undergone oxidative stress, display increased levels of overall and/or cell-surface K1 expression. Cell-surface keratins (CSKs) may be modified or truncated, and their role is yet to be fully elucidated. Current studies suggest that CSKs are involved in receptor-mediated endocytosis and immune evasion. In this Review, we discuss findings relating to K1 structure, overexpression, and cell-surface expression in the context of utilizing CSK1 as a receptor for targeted drug delivery to cancer cells, and other strategies to develop novel treatments for cancer.
Identifiants
pubmed: 34890750
pii: S0304-419X(21)00162-1
doi: 10.1016/j.bbcan.2021.188664
pmc: PMC8818032
mid: NIHMS1765538
pii:
doi:
Substances chimiques
Keratin-1
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
188664Subventions
Organisme : NIAMS NIH HHS
ID : R01 AR079428
Pays : United States
Organisme : NIAMS NIH HHS
ID : R03 AR076484
Pays : United States
Organisme : NCI NIH HHS
ID : R15 CA208656
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.
Références
J Biomed Sci. 2016 Jan 22;23:14
pubmed: 26801988
Br J Cancer. 1998 Dec;78(12):1640-4
pubmed: 9862577
Cells. 2019 May 23;8(5):
pubmed: 31126068
Genes Cells. 2020 Jun;25(6):413-426
pubmed: 32243065
EMBO J. 2019 Jun 3;38(11):
pubmed: 31036554
Nat Rev Clin Oncol. 2017 Mar;14(3):155-167
pubmed: 27644321
Protein J. 2012 Mar;31(3):195-205
pubmed: 22354665
Curr Opin Cell Biol. 2015 Feb;32:56-64
pubmed: 25594948
J Biol Chem. 2002 Jun 14;277(24):21712-22
pubmed: 11923318
Mol Pharm. 2017 Mar 6;14(3):593-604
pubmed: 28157321
J Clin Invest. 2009 Jul;119(7):1756-62
pubmed: 19587450
Cold Spring Harb Perspect Biol. 2016 Nov 1;8(11):
pubmed: 27803112
Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3615-20
pubmed: 9520414
Tumour Biol. 2013 Jun;34(3):1685-9
pubmed: 23430585
Clin Chim Acta. 2011 Nov 20;412(23-24):2310-5
pubmed: 21924253
Am J Pathol. 2001 Sep;159(3):1045-54
pubmed: 11549596
J Med Chem. 2017 Jun 22;60(12):4893-4903
pubmed: 28520410
Lancet. 2019 Aug 31;394(10200):793-804
pubmed: 31478503
Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):13438-13443
pubmed: 27821726
Science. 2018 Feb 9;359(6376):698-701
pubmed: 29439243
Proc Natl Acad Sci U S A. 2020 Sep 22;117(38):23510-23518
pubmed: 32907935
Mol Aspects Med. 2020 Apr;72:100817
pubmed: 31563278
Chem Soc Rev. 2019 Aug 12;48(16):4361-4374
pubmed: 31294429
Genomics. 1995 Aug 10;28(3):367-76
pubmed: 7490069
Curr Opin Cell Biol. 2015 Feb;32:73-81
pubmed: 25599598
J Med Chem. 2013 Oct 10;56(19):7564-73
pubmed: 24028446
Proc Natl Acad Sci U S A. 1997 Jul 22;94(15):8110-5
pubmed: 9223323
J Cell Sci. 1991 Jul;99 ( Pt 3):595-607
pubmed: 1719006
Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Mar;1864(3):234-244
pubmed: 30521939
Pharmaceutics. 2021 May 05;13(5):
pubmed: 34063098
Veroff Pathol. 1993;142:1-197
pubmed: 7504860
Biochim Biophys Acta. 2015 Nov;1853(11 Pt A):2966-74
pubmed: 26343611
J Proteomics. 2012 Apr 18;75(8):2352-60
pubmed: 22348822
Essays Biochem. 2019 Oct 31;63(5):521-533
pubmed: 31652439
Cancer Lett. 2001 Oct 10;171(2):153-64
pubmed: 11520599
BMJ Open Respir Res. 2020 Sep;7(1):
pubmed: 32913008
Annu Rev Pharmacol Toxicol. 2021 Jan 6;61:309-332
pubmed: 33022184
Proc Natl Acad Sci U S A. 1990 Mar;87(6):2319-23
pubmed: 1690428
Bioessays. 2016 Mar;38(3):232-43
pubmed: 26763143
Int J Cancer. 2003 Nov 20;107(4):597-602
pubmed: 14520698
Int J Biol Macromol. 1991 Jun;13(3):130-9
pubmed: 1716976
Biochem Biophys Res Commun. 2005 Mar 25;328(4):1154-62
pubmed: 15707998
Oncogene. 2011 Jan 13;30(2):127-38
pubmed: 20890307
Curr Opin Cell Biol. 2021 Feb;68:132-143
pubmed: 33190098
Cancer Lett. 2008 Aug 18;267(1):75-84
pubmed: 18433993
J Med Chem. 2021 Jan 14;64(1):216-232
pubmed: 33382619
Chem Sci. 2019 Dec 18;11(5):1368-1374
pubmed: 34123261
J Invest Dermatol. 2017 Jan;137(1):142-150
pubmed: 27595935
Int J Mol Sci. 2020 Sep 10;21(18):
pubmed: 32927888
J Cell Sci. 2020 Nov 5;134(5):
pubmed: 33154171
Cell. 1982 Nov;31(1):11-24
pubmed: 6186379
Biochem Soc Trans. 2007 Nov;35(Pt 5):1292-4
pubmed: 17956333
Mol Pharmacol. 2019 Aug;96(2):219-232
pubmed: 31164387
Biomaterials. 2013 May;34(16):4089-4097
pubmed: 23465829
Bioconjug Chem. 2019 Dec 18;30(12):3098-3106
pubmed: 31715102
Biochem Biophys Res Commun. 2013 Nov 22;441(3):618-23
pubmed: 24183726