2-Aminobenzoxazole-appended coumarins as potent and selective inhibitors of tumour-associated carbonic anhydrases.
Antineoplastic Agents
/ chemical synthesis
Benzoxazoles
/ chemical synthesis
Carbonic Anhydrase Inhibitors
/ chemical synthesis
Carbonic Anhydrases
/ metabolism
Cell Line, Tumor
Cell Proliferation
/ drug effects
Coumarins
/ chemical synthesis
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Humans
Isoenzymes
/ antagonists & inhibitors
Molecular Docking Simulation
Molecular Structure
Structure-Activity Relationship
Carbonic anhydrases
antiproliferative agents
benzoxazoles
coumarins
docking
Journal
Journal of enzyme inhibition and medicinal chemistry
ISSN: 1475-6374
Titre abrégé: J Enzyme Inhib Med Chem
Pays: England
ID NLM: 101150203
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
entrez:
13
12
2021
pubmed:
14
12
2021
medline:
24
2
2022
Statut:
ppublish
Résumé
We have carried out the design, synthesis, and evaluation of a small library of 2-aminobenzoxazole-appended coumarins as novel inhibitors of tumour-related CAs IX and XII. Substituents on C-3 and/or C-4 positions of the coumarin scaffold, and on the benzoxazole moiety, together with the length of the linker connecting both units were modified to obtain useful structure-activity relationships. CA inhibition studies revealed a good selectivity towards tumour-associated CAs IX and XII (
Identifiants
pubmed: 34894971
doi: 10.1080/14756366.2021.1998026
pmc: PMC8667885
doi:
Substances chimiques
Antineoplastic Agents
0
Benzoxazoles
0
Carbonic Anhydrase Inhibitors
0
Coumarins
0
Isoenzymes
0
Carbonic Anhydrases
EC 4.2.1.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
168-177Références
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