Application of a complete blood count to screening lethargic and anorectic cats for pancreatitis.
Abdominal ultrasonography
Band neutrophil count
Eosinophil count
Feline pancreatic lipase immunoreactivity
Neutrophil-to-lymphocyte ratio
White blood cell count
fPLI
Journal
BMC veterinary research
ISSN: 1746-6148
Titre abrégé: BMC Vet Res
Pays: England
ID NLM: 101249759
Informations de publication
Date de publication:
11 Dec 2021
11 Dec 2021
Historique:
received:
26
04
2021
accepted:
29
11
2021
entrez:
13
12
2021
pubmed:
14
12
2021
medline:
8
1
2022
Statut:
epublish
Résumé
Feline pancreatitis (FP) is an important health problem of cats. Its diagnostics is based on the combination of quantification of serum pancreatic lipase immunoreactivity (fPLI) and abdominal ultrasonography (AUS). These modalities allow for establishing highly specific diagnosis, however they are relatively expensive and time-consuming. On the other hand, a screening test of high sensitivity which would allow to rule out FP on the first visit without a considerable increase of costs would be clinically useful. To evaluate accuracy of nonspecific inflammatory biomarkers based on complete blood count (CBC) in diagnosing FP 73 client-owned cats with signs of lethargy and reduced appetite lasting for at least 2 days before presentation were enrolled in the cross-sectional study. They were examined with fPLI assay and AUS and classified as cats with very low risk of FP when fPLI ≤3.5 μg/L and AUS negative for FP, or as cats with increased risk of FP in the case of any other combination of results. Then, 7 various CBC measurements were measured in each cat and linked to the risk of FP using the multivariable logistic regression. Five CBC measurements turned out to be significantly associated with the risk of FP - total leukocyte count (WBC; crude odds ratio(OR The combination of three CBC measurements is an immediately available and fairly accurate screening method for identification of lethargic and anorectic cats with increased risk of FP.
Sections du résumé
BACKGROUND
BACKGROUND
Feline pancreatitis (FP) is an important health problem of cats. Its diagnostics is based on the combination of quantification of serum pancreatic lipase immunoreactivity (fPLI) and abdominal ultrasonography (AUS). These modalities allow for establishing highly specific diagnosis, however they are relatively expensive and time-consuming. On the other hand, a screening test of high sensitivity which would allow to rule out FP on the first visit without a considerable increase of costs would be clinically useful. To evaluate accuracy of nonspecific inflammatory biomarkers based on complete blood count (CBC) in diagnosing FP 73 client-owned cats with signs of lethargy and reduced appetite lasting for at least 2 days before presentation were enrolled in the cross-sectional study. They were examined with fPLI assay and AUS and classified as cats with very low risk of FP when fPLI ≤3.5 μg/L and AUS negative for FP, or as cats with increased risk of FP in the case of any other combination of results. Then, 7 various CBC measurements were measured in each cat and linked to the risk of FP using the multivariable logistic regression.
RESULTS
RESULTS
Five CBC measurements turned out to be significantly associated with the risk of FP - total leukocyte count (WBC; crude odds ratio(OR
CONCLUSION
CONCLUSIONS
The combination of three CBC measurements is an immediately available and fairly accurate screening method for identification of lethargic and anorectic cats with increased risk of FP.
Identifiants
pubmed: 34895249
doi: 10.1186/s12917-021-03098-z
pii: 10.1186/s12917-021-03098-z
pmc: PMC8665532
doi:
Types de publication
Evaluation Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
383Informations de copyright
© 2021. The Author(s).
Références
J Vet Intern Med. 2013 Sep-Oct;27(5):1077-82
pubmed: 23888903
J Small Anim Pract. 2015 Jan;56(1):13-26
pubmed: 25586803
J Vet Intern Med. 2001 Jul-Aug;15(4):329-33
pubmed: 11467589
Surgery. 2016 Jun;159(6):1638-1645
pubmed: 26962006
J Vet Intern Med. 2001 Jul-Aug;15(4):327-8
pubmed: 11467588
Vet Comp Oncol. 2021 Sep;19(3):482-491
pubmed: 33576562
J Gen Intern Med. 2002 Aug;17(8):646-9
pubmed: 12213147
J Am Vet Med Assoc. 2000 Aug 15;217(4):531-5
pubmed: 10953718
Am J Emerg Med. 2020 Mar;38(3):641-647
pubmed: 31785981
Vet Comp Oncol. 2020 Mar;18(1):105-116
pubmed: 31441996
N Engl J Med. 1975 Jul 31;293(5):257
pubmed: 1143310
Vet J. 2016 Sep;215:87-95
pubmed: 26951862
J Toxicol Sci. 2001 May;26(2):103-9
pubmed: 11429968
J Chronic Dis. 1981;34(12):599-610
pubmed: 6458624
Vet J. 2008 Jul;177(1):26-35
pubmed: 17686640
J Comp Pathol. 2020 Jan;174:63-72
pubmed: 31955805
Vet Clin Pathol. 2012 Sep;41(3):312-24
pubmed: 22861648
Vet Clin North Am Small Anim Pract. 2020 Sep;50(5):1107-1121
pubmed: 32680667
J Am Anim Hosp Assoc. 2018 Nov/Dec;54(6):351-359
pubmed: 30272478
J Vet Intern Med. 2021 Mar;35(2):703-723
pubmed: 33587762
Vet Pathol. 2007 Jan;44(1):39-49
pubmed: 17197622
J Vet Intern Med. 2004 Nov-Dec;18(6):807-15
pubmed: 15638263
Stat Med. 1987 Jun;6(4):411-23
pubmed: 3114858
J Vet Intern Med. 2013 Jul-Aug;27(4):913-8
pubmed: 23731243
Top Companion Anim Med. 2008 Nov;23(4):185-92
pubmed: 19081552
J Am Vet Med Assoc. 2003 Aug 15;223(4):469-74
pubmed: 12930084
Res Vet Sci. 2019 Oct;126:150-154
pubmed: 31493682
Vet Rec. 2018 Dec 1;183(21):656
pubmed: 30254131
J Vet Intern Med. 1993 Jan-Feb;7(1):25-33
pubmed: 8455180
BMJ. 2004 Jul 17;329(7458):168-9
pubmed: 15258077
J Am Vet Med Assoc. 2011 Apr 1;238(7):890-7
pubmed: 21453177
J Vet Intern Med. 2016 May;30(3):764-70
pubmed: 26968865
Vet Clin Pathol. 2021 Mar;50(1):45-51
pubmed: 33759228
Evid Based Med. 2013 Aug;18(4):125-8
pubmed: 23468201
J Am Vet Med Assoc. 2014 May 1;244(9):1060-5
pubmed: 24739116
Biometrics. 1988 Sep;44(3):837-45
pubmed: 3203132
Health Technol Assess. 2007 Dec;11(50):iii, ix-51
pubmed: 18021577