Duration of SARS-CoV-2 viremia and its correlation to mortality and inflammatory parameters in patients hospitalized for COVID-19: a cohort study.


Journal

Diagnostic microbiology and infectious disease
ISSN: 1879-0070
Titre abrégé: Diagn Microbiol Infect Dis
Pays: United States
ID NLM: 8305899

Informations de publication

Date de publication:
Mar 2022
Historique:
received: 21 09 2021
revised: 06 11 2021
accepted: 10 11 2021
pubmed: 14 12 2021
medline: 16 2 2022
entrez: 13 12 2021
Statut: ppublish

Résumé

SARS-CoV-2 viremia at admission is associated with high risk for mortality. However, longitudinal data on viremia duration are limited. Viremic patients hospitalized for COVID-19 were included in a cohort. Time to serum viral clearance and the effect of viremia duration on the odds of mortality were calculated. One hundred and twenty-one viremic patients were included. Median age was 62 (IQR 52-71) years and 68% were males. The total in-hospital mortality of the cohort was 33%. Median time from admission to serum viral clearance was 7 (95% CI 6-8) days. Duration of viremia showed a relative risk ratio of 1.40 (95% CI 1.02-1.92) for the odds of mortality in an adjusted multinomial logistic regression. Serum viral clearance coincided with defervescence and decreasing C-reactive protein. Median time to serum viral clearance was 7 days after admission. The odds of mortality increased with 40% for each additional day of viremia.

Identifiants

pubmed: 34896666
pii: S0732-8893(21)00286-8
doi: 10.1016/j.diagmicrobio.2021.115595
pmc: PMC8595972
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

115595

Informations de copyright

Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.

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Auteurs

Karl Hagman (K)

Department of Infectious Diseases, Danderyd Hospital, Stockholm, Sweden; Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden. Electronic address: karl.hagman@ki.se.

Magnus Hedenstierna (M)

Department of Infectious Diseases, Danderyd Hospital, Stockholm, Sweden.

Johan Rudling (J)

Department of Infectious Diseases, Danderyd Hospital, Stockholm, Sweden.

Patrik Gille-Johnson (P)

Department of Infectious Diseases, Danderyd Hospital, Stockholm, Sweden.

Berit Hammas (B)

Department of Microbiology, Karolinska University Hospital, Stockholm Sweden.

Malin Grabbe (M)

Department of Microbiology, Karolinska University Hospital, Stockholm Sweden.

Jan Jakobsson (J)

Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden; Department of Anesthesia and Intensive Care, Danderyd Hospital, Stockholm, Sweden.

Joakim Dillner (J)

Karolinska University Laboratory, Stockholm, Sweden.

Johan Ursing (J)

Department of Infectious Diseases, Danderyd Hospital, Stockholm, Sweden; Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden.

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