Macrophages Are the Key Players in Promoting Hyper-Inflammatory Response in a Mouse Model of TB-IRIS.
Adoptive Transfer
Animals
Biomarkers
CD4-Positive T-Lymphocytes
/ immunology
Coinfection
Cytokines
/ metabolism
Disease Models, Animal
HIV Infections
/ complications
Immune Reconstitution Inflammatory Syndrome
/ diagnosis
Inflammation Mediators
/ metabolism
Lymphocyte Activation
Lysosomes
Macrophages
/ immunology
Mice
Mice, Knockout
Nitric Oxide
/ metabolism
Phagosomes
Receptors, Antigen, T-Cell, alpha-beta
/ deficiency
Tuberculosis
/ complications
HIV—human immunodeficiency virus
Mycobacterium tuberculosis
TB-IRIS-tuberculosis-associated IRIS
inflammation
macrophage
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
13
09
2021
accepted:
29
10
2021
entrez:
13
12
2021
pubmed:
14
12
2021
medline:
11
2
2022
Statut:
epublish
Résumé
TB-IRIS is an abnormal inflammatory response in a subset of HIV-TB co-infected patients shortly after initiation of anti-retroviral therapy (ART). Therapy in these patients could have greatly improved the life expectancy as ART reconstitutes the function and number of CD4+ T cells and many patients see improvement in symptoms but paradoxically up to 54% of co-infected patients develop TB-IRIS. Different studies have indicated that both innate and adaptive immunity are involved in the pathology of IRIS but the role of macrophages in abnormal activation of CD4+ T cells is poorly understood. Since macrophages are one of the major antigen-presenting cells and are infected by M.tb at a high frequency, they are very much likely to be involved in the development of TB-IRIS. In this study, we have developed a mouse model of experimental IRIS, in which M.tb-infected T-cell knockout mice undergo a fatal inflammatory disease after CD4+ T cell reconstitution. Lung macrophages and blood monocytes from M.tb-infected TCRβ
Identifiants
pubmed: 34899731
doi: 10.3389/fimmu.2021.775177
pmc: PMC8662811
doi:
Substances chimiques
Biomarkers
0
Cytokines
0
Inflammation Mediators
0
Receptors, Antigen, T-Cell, alpha-beta
0
Nitric Oxide
31C4KY9ESH
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
775177Informations de copyright
Copyright © 2021 Pal, Nandani, Kumar, Swami, Roy and Bhaskar.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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