Role of microRNAs in response to cadmium chloride in pancreatic ductal adenocarcinoma.
Apoptosis
Cadmium
EMT
LC50
Non-coding RNAs
Pancreatic ductal adenocarcinoma
microRNAs
Journal
Archives of toxicology
ISSN: 1432-0738
Titre abrégé: Arch Toxicol
Pays: Germany
ID NLM: 0417615
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
received:
07
09
2021
accepted:
10
11
2021
pubmed:
15
12
2021
medline:
29
3
2022
entrez:
14
12
2021
Statut:
ppublish
Résumé
Pancreatic ductal adenocarcinoma (PDAC) is one of the most fatal and aggressive malignancies with a 5-year survival rate less than 9%. Early detection is particularly difficult due to the lack of symptoms even in advanced stages. microRNAs (miRs/miRNAs) are small (~ 18-24 nucleotides), endogenous, non-coding RNAs, which are involved in the pathogenesis of several malignancies including PDAC. Alterations of miR expressions can lead to apoptosis, angiogenesis, and metastasis. The role of environmental pollutants such as cadmium (Cd) in PDAC has been suggested but not fully understood. This study underlines the role of miRs (miR-221, miR-155, miR-126) in response to cadmium chloride (CdCl
Identifiants
pubmed: 34905088
doi: 10.1007/s00204-021-03196-9
pii: 10.1007/s00204-021-03196-9
pmc: PMC8837568
doi:
Substances chimiques
Environmental Pollutants
0
MIRN126 microRNA, human
0
MIRN155 microRNA, human
0
MIRN221 microRNA, human
0
MicroRNAs
0
Cadmium Chloride
J6K4F9V3BA
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
467-485Informations de copyright
© 2021. The Author(s).
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