Association of Cognitive Impairment With Free Water in the Nucleus Basalis of Meynert and Locus Coeruleus to Transentorhinal Cortex Tract.

Alzheimer Disease / psychology Basal Forebrain Basal Nucleus of Meynert Cognitive Dysfunction / diagnostic imaging Humans Locus Coeruleus / diagnostic imaging Water

Journal

Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060

Informations de publication

Date de publication:
15 02 2022
Historique:
received: 22 04 2021
accepted: 30 11 2021
pubmed: 16 12 2021
medline: 7 4 2022
entrez: 15 12 2021
Statut: ppublish

Résumé

The goal of this work was to determine the relationship between diffusion microstructure and early changes in Alzheimer disease (AD) severity as assessed by clinical diagnosis, cognitive performance, dementia severity, and plasma concentrations of neurofilament light chain. Diffusion MRI scans were collected on cognitively normal participants (CN) and patients with early mild cognitive impairment (EMCI), late mild cognitive impairment, and AD. Free water (FW) and FW-corrected fractional anisotropy were calculated in the locus coeruleus to transentorhinal cortex tract, 4 magnocellular regions of the basal forebrain (e.g., nucleus basalis of Meynert), entorhinal cortex, and hippocampus. All patients underwent a battery of cognitive assessments; neurofilament light chain levels were measured in plasma samples. FW was significantly higher in patients with EMCI compared to CN in the locus coeruleus to transentorhinal cortex tract, nucleus basalis of Meynert, and hippocampus (mean Cohen These results show that higher FW is associated with greater clinical diagnosis severity, cognitive impairment, and neurofilament light chain. They also suggest that FW elevation occurs in the locus coeruleus to transentorhinal cortex tract, nucleus basalis of Meynert, and hippocampus in the transition from CN to EMCI, while other basal forebrain regions and the entorhinal cortex are not affected until a later stage of AD. FW is a clinically relevant and noninvasive early marker of structural changes related to cognitive impairment.

Sections du résumé

BACKGROUND AND OBJECTIVES
The goal of this work was to determine the relationship between diffusion microstructure and early changes in Alzheimer disease (AD) severity as assessed by clinical diagnosis, cognitive performance, dementia severity, and plasma concentrations of neurofilament light chain.
METHODS
Diffusion MRI scans were collected on cognitively normal participants (CN) and patients with early mild cognitive impairment (EMCI), late mild cognitive impairment, and AD. Free water (FW) and FW-corrected fractional anisotropy were calculated in the locus coeruleus to transentorhinal cortex tract, 4 magnocellular regions of the basal forebrain (e.g., nucleus basalis of Meynert), entorhinal cortex, and hippocampus. All patients underwent a battery of cognitive assessments; neurofilament light chain levels were measured in plasma samples.
RESULTS
FW was significantly higher in patients with EMCI compared to CN in the locus coeruleus to transentorhinal cortex tract, nucleus basalis of Meynert, and hippocampus (mean Cohen
DISCUSSION
These results show that higher FW is associated with greater clinical diagnosis severity, cognitive impairment, and neurofilament light chain. They also suggest that FW elevation occurs in the locus coeruleus to transentorhinal cortex tract, nucleus basalis of Meynert, and hippocampus in the transition from CN to EMCI, while other basal forebrain regions and the entorhinal cortex are not affected until a later stage of AD. FW is a clinically relevant and noninvasive early marker of structural changes related to cognitive impairment.

Identifiants

DOI: 10.1212/WNL.0000000000013206 PMID: 34906980 PMC: PMC8865892
pubmed: 34906980
pii: WNL.0000000000013206
doi: 10.1212/WNL.0000000000013206
pmc: PMC8865892
doi:

Substances chimiques

Water 059QF0KO0R

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

e700-e710

Subventions

Organisme : NINDS NIH HHS
ID : R01 NS052318
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS023945
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG066506
Pays : United States
Organisme : NINDS NIH HHS
ID : RF1 NS023945
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG047266
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS058487
Pays : United States

Informations de copyright

© 2021 American Academy of Neurology.

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Auteurs

Winston Thomas Chu (WT)

From the J. Crayton Pruitt Family Department of Biomedical Engineering (W.T.C., D.E.V.), Department of Applied Physiology and Kinesiology (W.T.C., W.-e.W., S.A.C., D.E.V.), Department of Neuroscience (T.E.G.); Center for Translational Research in Neurodegenerative Diseases (T.E.G.), Department of Neurology (S.D., D.E.V.), and McKnight Brain Institute (S.D., D.E.V.), University of Florida, Gainesville; Center for Molecular and Behavioral Neuroscience (L.Z.), Rutgers University, Newark, NJ; Wein Center for Alzheimer's Disease and Memory Disorders (R.D., D.A.L.), Mount Sinai Medical Center, Miami Beach; Center for Cognitive Neuroscience and Aging (D.A.L.) and Department of Psychiatry and Behavioral Sciences (D.A.L.), University of Miami Miller School of Medicine; and Center for Advanced Technology and Education (M.A.), Florida International University, Miami.
ORCID: 0000-0001-7818-9139

Wei-En Wang (WE)

From the J. Crayton Pruitt Family Department of Biomedical Engineering (W.T.C., D.E.V.), Department of Applied Physiology and Kinesiology (W.T.C., W.-e.W., S.A.C., D.E.V.), Department of Neuroscience (T.E.G.); Center for Translational Research in Neurodegenerative Diseases (T.E.G.), Department of Neurology (S.D., D.E.V.), and McKnight Brain Institute (S.D., D.E.V.), University of Florida, Gainesville; Center for Molecular and Behavioral Neuroscience (L.Z.), Rutgers University, Newark, NJ; Wein Center for Alzheimer's Disease and Memory Disorders (R.D., D.A.L.), Mount Sinai Medical Center, Miami Beach; Center for Cognitive Neuroscience and Aging (D.A.L.) and Department of Psychiatry and Behavioral Sciences (D.A.L.), University of Miami Miller School of Medicine; and Center for Advanced Technology and Education (M.A.), Florida International University, Miami.

Laszlo Zaborszky (L)

From the J. Crayton Pruitt Family Department of Biomedical Engineering (W.T.C., D.E.V.), Department of Applied Physiology and Kinesiology (W.T.C., W.-e.W., S.A.C., D.E.V.), Department of Neuroscience (T.E.G.); Center for Translational Research in Neurodegenerative Diseases (T.E.G.), Department of Neurology (S.D., D.E.V.), and McKnight Brain Institute (S.D., D.E.V.), University of Florida, Gainesville; Center for Molecular and Behavioral Neuroscience (L.Z.), Rutgers University, Newark, NJ; Wein Center for Alzheimer's Disease and Memory Disorders (R.D., D.A.L.), Mount Sinai Medical Center, Miami Beach; Center for Cognitive Neuroscience and Aging (D.A.L.) and Department of Psychiatry and Behavioral Sciences (D.A.L.), University of Miami Miller School of Medicine; and Center for Advanced Technology and Education (M.A.), Florida International University, Miami.

Todd Eliot Golde (TE)

From the J. Crayton Pruitt Family Department of Biomedical Engineering (W.T.C., D.E.V.), Department of Applied Physiology and Kinesiology (W.T.C., W.-e.W., S.A.C., D.E.V.), Department of Neuroscience (T.E.G.); Center for Translational Research in Neurodegenerative Diseases (T.E.G.), Department of Neurology (S.D., D.E.V.), and McKnight Brain Institute (S.D., D.E.V.), University of Florida, Gainesville; Center for Molecular and Behavioral Neuroscience (L.Z.), Rutgers University, Newark, NJ; Wein Center for Alzheimer's Disease and Memory Disorders (R.D., D.A.L.), Mount Sinai Medical Center, Miami Beach; Center for Cognitive Neuroscience and Aging (D.A.L.) and Department of Psychiatry and Behavioral Sciences (D.A.L.), University of Miami Miller School of Medicine; and Center for Advanced Technology and Education (M.A.), Florida International University, Miami.

Steven DeKosky (S)

From the J. Crayton Pruitt Family Department of Biomedical Engineering (W.T.C., D.E.V.), Department of Applied Physiology and Kinesiology (W.T.C., W.-e.W., S.A.C., D.E.V.), Department of Neuroscience (T.E.G.); Center for Translational Research in Neurodegenerative Diseases (T.E.G.), Department of Neurology (S.D., D.E.V.), and McKnight Brain Institute (S.D., D.E.V.), University of Florida, Gainesville; Center for Molecular and Behavioral Neuroscience (L.Z.), Rutgers University, Newark, NJ; Wein Center for Alzheimer's Disease and Memory Disorders (R.D., D.A.L.), Mount Sinai Medical Center, Miami Beach; Center for Cognitive Neuroscience and Aging (D.A.L.) and Department of Psychiatry and Behavioral Sciences (D.A.L.), University of Miami Miller School of Medicine; and Center for Advanced Technology and Education (M.A.), Florida International University, Miami.

Ranjan Duara (R)

From the J. Crayton Pruitt Family Department of Biomedical Engineering (W.T.C., D.E.V.), Department of Applied Physiology and Kinesiology (W.T.C., W.-e.W., S.A.C., D.E.V.), Department of Neuroscience (T.E.G.); Center for Translational Research in Neurodegenerative Diseases (T.E.G.), Department of Neurology (S.D., D.E.V.), and McKnight Brain Institute (S.D., D.E.V.), University of Florida, Gainesville; Center for Molecular and Behavioral Neuroscience (L.Z.), Rutgers University, Newark, NJ; Wein Center for Alzheimer's Disease and Memory Disorders (R.D., D.A.L.), Mount Sinai Medical Center, Miami Beach; Center for Cognitive Neuroscience and Aging (D.A.L.) and Department of Psychiatry and Behavioral Sciences (D.A.L.), University of Miami Miller School of Medicine; and Center for Advanced Technology and Education (M.A.), Florida International University, Miami.
ORCID: 0000-0001-8060-6309

David A Loewenstein (DA)

From the J. Crayton Pruitt Family Department of Biomedical Engineering (W.T.C., D.E.V.), Department of Applied Physiology and Kinesiology (W.T.C., W.-e.W., S.A.C., D.E.V.), Department of Neuroscience (T.E.G.); Center for Translational Research in Neurodegenerative Diseases (T.E.G.), Department of Neurology (S.D., D.E.V.), and McKnight Brain Institute (S.D., D.E.V.), University of Florida, Gainesville; Center for Molecular and Behavioral Neuroscience (L.Z.), Rutgers University, Newark, NJ; Wein Center for Alzheimer's Disease and Memory Disorders (R.D., D.A.L.), Mount Sinai Medical Center, Miami Beach; Center for Cognitive Neuroscience and Aging (D.A.L.) and Department of Psychiatry and Behavioral Sciences (D.A.L.), University of Miami Miller School of Medicine; and Center for Advanced Technology and Education (M.A.), Florida International University, Miami.

Malek Adjouadi (M)

From the J. Crayton Pruitt Family Department of Biomedical Engineering (W.T.C., D.E.V.), Department of Applied Physiology and Kinesiology (W.T.C., W.-e.W., S.A.C., D.E.V.), Department of Neuroscience (T.E.G.); Center for Translational Research in Neurodegenerative Diseases (T.E.G.), Department of Neurology (S.D., D.E.V.), and McKnight Brain Institute (S.D., D.E.V.), University of Florida, Gainesville; Center for Molecular and Behavioral Neuroscience (L.Z.), Rutgers University, Newark, NJ; Wein Center for Alzheimer's Disease and Memory Disorders (R.D., D.A.L.), Mount Sinai Medical Center, Miami Beach; Center for Cognitive Neuroscience and Aging (D.A.L.) and Department of Psychiatry and Behavioral Sciences (D.A.L.), University of Miami Miller School of Medicine; and Center for Advanced Technology and Education (M.A.), Florida International University, Miami.

Stephen A Coombes (SA)

From the J. Crayton Pruitt Family Department of Biomedical Engineering (W.T.C., D.E.V.), Department of Applied Physiology and Kinesiology (W.T.C., W.-e.W., S.A.C., D.E.V.), Department of Neuroscience (T.E.G.); Center for Translational Research in Neurodegenerative Diseases (T.E.G.), Department of Neurology (S.D., D.E.V.), and McKnight Brain Institute (S.D., D.E.V.), University of Florida, Gainesville; Center for Molecular and Behavioral Neuroscience (L.Z.), Rutgers University, Newark, NJ; Wein Center for Alzheimer's Disease and Memory Disorders (R.D., D.A.L.), Mount Sinai Medical Center, Miami Beach; Center for Cognitive Neuroscience and Aging (D.A.L.) and Department of Psychiatry and Behavioral Sciences (D.A.L.), University of Miami Miller School of Medicine; and Center for Advanced Technology and Education (M.A.), Florida International University, Miami.

David E Vaillancourt (DE)

From the J. Crayton Pruitt Family Department of Biomedical Engineering (W.T.C., D.E.V.), Department of Applied Physiology and Kinesiology (W.T.C., W.-e.W., S.A.C., D.E.V.), Department of Neuroscience (T.E.G.); Center for Translational Research in Neurodegenerative Diseases (T.E.G.), Department of Neurology (S.D., D.E.V.), and McKnight Brain Institute (S.D., D.E.V.), University of Florida, Gainesville; Center for Molecular and Behavioral Neuroscience (L.Z.), Rutgers University, Newark, NJ; Wein Center for Alzheimer's Disease and Memory Disorders (R.D., D.A.L.), Mount Sinai Medical Center, Miami Beach; Center for Cognitive Neuroscience and Aging (D.A.L.) and Department of Psychiatry and Behavioral Sciences (D.A.L.), University of Miami Miller School of Medicine; and Center for Advanced Technology and Education (M.A.), Florida International University, Miami. vcourt@ufl.edu.

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Association of Cognitive Impairment With Free...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex olfactif › Prosencéphale basal › Association of Cognitive Impairment With Free...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Noyaux gris centraux › Substance innominée › Noyau basal de Meynert › Association of Cognitive Impairment With Free...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Troubles de la cognition › Dysfonctionnement cognitif › Association of Cognitive Impairment With Free...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Association of Cognitive Impairment With Free...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Tronc cérébral › Rhombencéphale › Métencéphale › Pont › Tegmentum pontin › Locus ceruleus › Association of Cognitive Impairment With Free...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Eau › Association of Cognitive Impairment With Free...