Genetic variants at the
autoimmune diseases
genetic
polymorphism
sjogren's syndrome
Journal
RMD open
ISSN: 2056-5933
Titre abrégé: RMD Open
Pays: England
ID NLM: 101662038
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
received:
19
07
2021
accepted:
19
11
2021
entrez:
15
12
2021
pubmed:
16
12
2021
medline:
5
1
2022
Statut:
ppublish
Résumé
Fatigue is common and severe in primary Sjögren's syndrome (pSS). The aim of this study was to identify genetic determinants of fatigue in pSS through a genome-wide association study. Patients with pSS from Norway, Sweden, UK and USA with fatigue and genotype data available were included. After genotype imputation and quality control, 682 patients and 4 966 157 genetic markers were available. Association analysis in each cohort using linear regression with fatigue as a continuous variable and meta-analyses between the cohorts were performed. Meta-analysis of the Norwegian and Swedish cohorts identified five polymorphisms within the same linkage disequilibrium block at the receptor transporter protein 4 ( Genetic variations at
Identifiants
pubmed: 34907023
pii: rmdopen-2021-001832
doi: 10.1136/rmdopen-2021-001832
pmc: PMC8671987
pii:
doi:
Substances chimiques
MASP1 protein, human
EC 3.4.21.-
Mannose-Binding Protein-Associated Serine Proteases
EC 3.4.21.-
Types de publication
Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : U19 AI082714
Pays : United States
Organisme : Medical Research Council
ID : MR/J002720/1
Pays : United Kingdom
Organisme : NIDCR NIH HHS
ID : U01 DE017593
Pays : United States
Organisme : Medical Research Council
ID : G0800629
Pays : United Kingdom
Organisme : NIDCR NIH HHS
ID : R01 DE018209
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR065953
Pays : United States
Informations de copyright
© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
Références
Rheumatology (Oxford). 2010 Jul;49(7):1294-302
pubmed: 20353956
J Neuroinflammation. 2013 Nov 23;10:139
pubmed: 24267924
Invest New Drugs. 2015 Jun;33(3):621-31
pubmed: 25822109
Nat Genet. 2009 Nov;41(11):1228-33
pubmed: 19838195
Front Immunol. 2019 Jul 19;10:1696
pubmed: 31379879
PLoS One. 2013 Dec 31;8(12):e83149
pubmed: 24391741
Neurosci Biobehav Rev. 1988 Summer;12(2):123-37
pubmed: 3050629
Nat Genet. 2010 Dec;42(12):1118-25
pubmed: 21102463
Arthritis Res Ther. 2015 Oct 05;17:254
pubmed: 26435495
J Crohns Colitis. 2015 Sep;9(9):725-30
pubmed: 25994356
Ann Rheum Dis. 2010 Jun;69(6):1103-9
pubmed: 19561361
J Rheumatol. 2004 Oct;31(10):1896-902
pubmed: 15468350
Innate Immun. 2016 Apr;22(3):162-7
pubmed: 26921255
Curr Opin Neurol. 2020 Jun;33(3):391-396
pubmed: 32304437
PLoS One. 2012;7(1):e30123
pubmed: 22253903
Nat Rev Neurosci. 2018 Mar;19(3):138-152
pubmed: 29416128
J Immunol. 2008 May 1;180(9):6132-8
pubmed: 18424734
Nat Genet. 2013 Oct;45(10):1238-1243
pubmed: 24013639
Nat Rev Genet. 2005 Apr;6(4):333-40
pubmed: 15803201
Trends Neurosci. 2014 Jan;37(1):39-46
pubmed: 24239063
Clin Exp Rheumatol. 2016 Jul-Aug;34(4 Suppl 98):21-4
pubmed: 27586799
Brain Behav Immun. 2009 Nov;23(8):1104-8
pubmed: 19560535
Curr Opin Neurol. 1996 Dec;9(6):456-60
pubmed: 9007405
Arthritis Care Res (Hoboken). 2014 Aug;66(8):1227-32
pubmed: 24339344
Brain Behav Immun. 2011 Oct;25(7):1376-83
pubmed: 21496483
Ann Rheum Dis. 2016 Nov;75(11):2029-2036
pubmed: 26857698
Nat Genet. 2014 Apr;46(4):409-15
pubmed: 24633160
Brain Behav Immun. 2017 May;62:230-244
pubmed: 28089639
Nat Genet. 2013 Nov;45(11):1284-92
pubmed: 24097067
SAGE Open Med. 2019 May 13;7:2050312119850390
pubmed: 31205695
Br J Dermatol. 2017 Aug;177(2):505-512
pubmed: 28182255
Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):16045-50
pubmed: 18836069
Ann Rheum Dis. 2015 May;74(5):859-66
pubmed: 24442883
Rheumatol Int. 2005 Aug;25(6):481-4
pubmed: 15071755
Rheumatology (Oxford). 2016 Jun;55(6):1074-82
pubmed: 26966136
Mol Neurobiol. 2015 Aug;52(1):318-29
pubmed: 25159480
PM R. 2010 May;2(5):456-65
pubmed: 20656628
Rheumatology (Oxford). 2011 Jun;50(6):1009-18
pubmed: 21285230
Mol Cell Biol. 2002 Dec;22(24):8506-13
pubmed: 12446770
J Stroke Cerebrovasc Dis. 2015 Mar;24(3):618-21
pubmed: 25542762
Nature. 2015 Oct 1;526(7571):68-74
pubmed: 26432245
Rheumatology (Oxford). 2019 Feb 15;:
pubmed: 30770713
Am J Hum Genet. 2007 Sep;81(3):559-75
pubmed: 17701901
Ann Rheum Dis. 2002 Jun;61(6):554-8
pubmed: 12006334
Arthritis Res Ther. 2011;13(5):R167
pubmed: 21996338
Scand J Immunol. 2018 May;87(5):e12662
pubmed: 29655283
Brain Behav Immun. 2012 Jul;26(5):699-705
pubmed: 22251605
Diabetes Care. 2011 Oct;34(10):e158
pubmed: 21949230
Clin Exp Rheumatol. 2017 Mar-Apr;35(2):255-261
pubmed: 28032845
PLoS One. 2012;7(6):e38668
pubmed: 22701688