Emergence and function of cortical offset responses in sound termination detection.
auditory cortex
auditory thalamus
electrophysiology
mouse
neuroscience
on/off responses
sensory perception
temporal processing
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
15 12 2021
15 12 2021
Historique:
received:
15
07
2021
accepted:
28
11
2021
entrez:
15
12
2021
pubmed:
16
12
2021
medline:
27
1
2022
Statut:
epublish
Résumé
Offset responses in auditory processing appear after a sound terminates. They arise in neuronal circuits within the peripheral auditory system, but their role in the central auditory system remains unknown. Here, we ask what the behavioral relevance of cortical offset responses is and what circuit mechanisms drive them. At the perceptual level, our results reveal that experimentally minimizing auditory cortical offset responses decreases the mouse performance to detect sound termination, assigning a behavioral role to offset responses. By combining in vivo electrophysiology in the auditory cortex and thalamus of awake mice, we also demonstrate that cortical offset responses are not only inherited from the periphery but also amplified and generated de novo. Finally, we show that offset responses code more than silence, including relevant changes in sound trajectories. Together, our results reveal the importance of cortical offset responses in encoding sound termination and detecting changes within temporally discontinuous sounds crucial for speech and vocalization.
Identifiants
pubmed: 34910627
doi: 10.7554/eLife.72240
pii: 72240
pmc: PMC8673837
doi:
pii:
Banques de données
Dryad
['10.5061/dryad.41ns1rnfg']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2021, Solyga and Barkat.
Déclaration de conflit d'intérêts
MS, TB No competing interests declared
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