Epithelial colonization by gut dendritic cells promotes their functional diversification.

Actomyosin / metabolism Animals Antigen Presentation Antigens, CD / metabolism CD11b Antigen / metabolism Cell Differentiation Cell Movement Cells, Cultured Dendritic Cells / immunology Immune Tolerance Inflammation / immunology Integrin alpha Chains / metabolism Intestinal Mucosa / pathology Mice Mice, Inbred C57BL Mice, Knockout Mucin-2 / immunology T-Lymphocytes / immunology Tretinoin / metabolism

T cell activation and tolerance antigen presentation epithelium immature and mature dendritic cells niche small intestine transmigration

Journal

Immunity

ISSN: 1097-4180

Titre abrégé: Immunity

Pays: United States

ID NLM: 9432918

Informations de publication

Date de publication:
11 01 2022

Historique:

received: 15 06 2021

revised: 19 08 2021

accepted: 15 11 2021

pubmed: 16 12 2021

medline: 23 2 2022

entrez: 15 12 2021

Statut: ppublish

Résumé

Dendritic cells (DCs) patrol tissues and transport antigens to lymph nodes to initiate adaptive immune responses. Within tissues, DCs constitute a complex cell population composed of distinct subsets that can exhibit different activation states and functions. How tissue-specific cues orchestrate DC diversification remains elusive. Here, we show that the small intestine included two pools of cDC2s originating from common pre-DC precursors: (1) lamina propria (LP) CD103

Identifiants

DOI: 10.1016/j.immuni.2021.11.008 PMID: 34910930 PMC: PMC8751639

pubmed: 34910930

pii: S1074-7613(21)00499-4

doi: 10.1016/j.immuni.2021.11.008

pmc: PMC8751639

pii:

doi:

Substances chimiques

Antigens, CD 0

CD11b Antigen 0

Integrin alpha Chains 0

MUC2 protein, human 0

Mucin-2 0

alpha E integrins 0

Tretinoin 5688UTC01R

Actomyosin 9013-26-7

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Pagination

129-144.e8

Informations de copyright

Déclaration de conflit d'intérêts

Declaration of interests C.R.S. has an additional appointment as professor in the Faculty of Medicine at Imperial College London. C.R.S. is a founder of Adendra Therapeutics and owns stock options and/or is a paid consultant for Adendra Therapeutics, Bicara Therapeutics, Montis Biosciences, Oncurious NV, Bicycle Therapeutics, and Sosei Heptares, all unrelated to this work.

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