Infant intakes of human milk branched chain amino acids are negatively associated with infant growth and influenced by maternal body mass index.
aromatic amino acids
branched-chain amino acids
breastmilk
essential amino acids
postnatal programming
Journal
Pediatric obesity
ISSN: 2047-6310
Titre abrégé: Pediatr Obes
Pays: England
ID NLM: 101572033
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
revised:
28
10
2021
received:
17
03
2021
accepted:
15
11
2021
pubmed:
17
12
2021
medline:
15
4
2022
entrez:
16
12
2021
Statut:
ppublish
Résumé
Branched-chain amino acids (BCAAs: isoleucine, leucine, and valine) and aromatic amino acids (AAAs: phenylalanine and tyrosine) are hypothesized to influence early-life obesity risk. To assess HM free amino acid (AA) concentrations and infant intakes of HM AAs from women with obesity (OB) compared to those with normal weight (NW) and determine the relationships between HM AA consumption and infant growth. HM samples were collected at 0.5 (n = 151), 2 (n = 129), and 6 (n = 93) months postpartum from mothers with NW (body mass index [BMI] = 18.5-24.9 kg/m Maternal BMI was positively associated with infant intakes of isoleucine, leucine, and AAAs across timepoints. HM AA intakes were positively associated with weight-for-length z-score, fat mass index, and fat-free mass index in infants (p < 0.05). Maternal BMI led to differences in HM AA composition, which was associated with infant body composition.
Sections du résumé
BACKGROUND
Branched-chain amino acids (BCAAs: isoleucine, leucine, and valine) and aromatic amino acids (AAAs: phenylalanine and tyrosine) are hypothesized to influence early-life obesity risk.
OBJECTIVE
To assess HM free amino acid (AA) concentrations and infant intakes of HM AAs from women with obesity (OB) compared to those with normal weight (NW) and determine the relationships between HM AA consumption and infant growth.
METHODS
HM samples were collected at 0.5 (n = 151), 2 (n = 129), and 6 (n = 93) months postpartum from mothers with NW (body mass index [BMI] = 18.5-24.9 kg/m
RESULTS
Maternal BMI was positively associated with infant intakes of isoleucine, leucine, and AAAs across timepoints. HM AA intakes were positively associated with weight-for-length z-score, fat mass index, and fat-free mass index in infants (p < 0.05).
CONCLUSIONS
Maternal BMI led to differences in HM AA composition, which was associated with infant body composition.
Identifiants
pubmed: 34913264
doi: 10.1111/ijpo.12876
pmc: PMC9269030
mid: NIHMS1763146
doi:
Substances chimiques
Isoleucine
04Y7590D77
Leucine
GMW67QNF9C
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12876Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK107516
Pays : United States
Informations de copyright
© 2021 World Obesity Federation.
Références
Nat Rev Endocrinol. 2014 Dec;10(12):723-36
pubmed: 25287287
Pediatrics. 2014 May;133(5):844-53
pubmed: 24777216
J Nutr. 2015 Aug;145(8):1698-708
pubmed: 26041675
BMC Pregnancy Childbirth. 2016 Nov 21;16(1):357
pubmed: 27871260
Ann Nutr Metab. 2014;64(3-4):294-303
pubmed: 25300273
Am J Hum Biol. 2007 Sep-Oct;19(5):684-91
pubmed: 17636528
J Pediatr Gastroenterol Nutr. 2000 Nov;31(5):508-12
pubmed: 11144435
J Clin Endocrinol Metab. 2015 Jan;100(1):149-58
pubmed: 25368978
Early Hum Dev. 1984 Apr;9(3):275-81
pubmed: 6734489
BMJ. 2005 Oct 22;331(7522):929
pubmed: 16227306
J Nutr. 2009 Aug;139(8):1502-9
pubmed: 19549750
Am J Clin Nutr. 1993 Aug;58(2):152-61
pubmed: 8338041
Hum Mol Genet. 2010 Nov 1;19(21):4176-88
pubmed: 20699328
J Adolesc Health. 2019 Sep;65(3):337-343
pubmed: 30905504
Nutrients. 2016 May 19;8(5):
pubmed: 27213440
Nestle Nutr Inst Workshop Ser. 2019;90:107-120
pubmed: 30865980
Nutrients. 2019 Feb 28;11(3):
pubmed: 30823457
Nestle Nutr Workshop Ser Pediatr Program. 2006;58:121-9; discussion 129-31
pubmed: 16902330
Am J Clin Nutr. 2007 Dec;86(6):1765-72
pubmed: 18065597
J Diabetes. 2018 May;10(5):350-352
pubmed: 29369529
Am J Clin Nutr. 2020 Sep 1;112(3):548-557
pubmed: 32401302
Nestle Nutr Inst Workshop Ser. 2016;85:81-8
pubmed: 27088335
Nutrients. 2013 Nov 26;5(12):4800-21
pubmed: 24288022
Eur J Nutr. 2017 Mar;56(2):613-620
pubmed: 26621633
Am J Clin Nutr. 2009 Jun;89(6):1836-45
pubmed: 19386747
Endocrinol Metab (Seoul). 2019 Sep;34(3):234-246
pubmed: 31565875
Obesity (Silver Spring). 2011 Oct;19(10):2089-95
pubmed: 21779094
Front Biosci (Landmark Ed). 2011 Jan 01;16(4):1445-60
pubmed: 21196241
Biochem Soc Trans. 2007 Nov;35(Pt 5):1298-301
pubmed: 17956335
Am J Physiol Cell Physiol. 2013 Sep 15;305(6):C623-31
pubmed: 23804198
Nestle Nutr Inst Workshop Ser. 2013;71:11-27
pubmed: 23502135
Am J Clin Nutr. 2019 Sep 1;110(3):769-779
pubmed: 31274142
J Pediatr Gastroenterol Nutr. 1998 Mar;26(3):297-304
pubmed: 9523865
Adv Exp Med Biol. 2001;501:415-21
pubmed: 11787711
Curr Opin Clin Nutr Metab Care. 2011 Jan;14(1):83-8
pubmed: 21076294
Nutrition. 2016 Nov-Dec;32(11-12):1295-8
pubmed: 27497516
Nestle Nutr Workshop Ser Pediatr Program. 2008;61:1-19
pubmed: 18196941
Am J Clin Nutr. 2011 Dec;94(6 Suppl):1776S-1784S
pubmed: 21849603
PeerJ. 2018 Aug 31;6:e5410
pubmed: 30186675
Amino Acids. 2015 Feb;47(2):259-70
pubmed: 25408462
Front Immunol. 2020 May 28;11:1007
pubmed: 32547547
Metabolites. 2020 Apr 10;10(4):
pubmed: 32290284
J Physiol. 2018 Feb 15;596(4):623-645
pubmed: 29266268
PLoS One. 2018 Jun 1;13(6):e0197713
pubmed: 29856767
Pediatr Obes. 2018 Oct;13(10):598-606
pubmed: 30092608
Pediatrics. 1985 Apr;75(4):775-84
pubmed: 3872443