Exome sequencing reveals candidate mutations implicated in sinonasal carcinoma and malignant transformation of sinonasal inverted papilloma.

Carcinoma, Squamous Cell / pathology Cell Transformation, Neoplastic / genetics Exome Humans Mutation Papilloma, Inverted / genetics Paranasal Sinus Neoplasms / pathology Squamous Cell Carcinoma of Head and Neck / genetics
Exome sequencing FGFR3 Genetic mutation Head and neck cancer Head and neck squamous cell carcinoma Inverted papilloma Sinonasal papilloma Somatic variant analysis

Journal

Oral oncology
ISSN: 1879-0593
Titre abrégé: Oral Oncol
Pays: England
ID NLM: 9709118

Informations de publication

Date de publication:
01 2022
Historique:
received: 24 06 2021
revised: 19 11 2021
accepted: 01 12 2021
pubmed: 17 12 2021
medline: 12 4 2022
entrez: 16 12 2021
Statut: ppublish

Résumé

We explored somatic mutations in dysplastic sinonasal inverted papilloma (SNIP), SNIP with concomitant sinonasal squamous cell carcinoma (SNSCC), and SNSCC without preceding SNIP. Ten SNIP and SNSCC samples were analyzed with exome sequencing and tested for human papillomavirus. The identified mutations were compared to the most frequently mutated genes in head and neck squamous cell carcinoma (HNSCC) in the COSMIC database. Exome sequencing data were also analyzed for mutations not previously linked to SNSCC. Seven of the most commonly mutated genes in HNSCC and SNSCC in COSMIC harbored mutations in our data. In addition, we identified mutations in 23 genes that are likely to contribute to SNIP and SNSCC oncogenesis.

Identifiants

DOI: 10.1016/j.oraloncology.2021.105663 PMID: 34915258
pubmed: 34915258
pii: S1368-8375(21)00770-3
doi: 10.1016/j.oraloncology.2021.105663
pii:
doi:

Types de publication

Letter

Langues

eng

Sous-ensembles de citation

IM

Pagination

105663

Informations de copyright

Copyright © 2021. Published by Elsevier Ltd.

Auteurs

Sanna Viitasalo (S)

Department of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. Electronic address: sanna.viitasalo@hus.fi.

Piia-Riitta Karhemo (PR)

Applied Tumor Genomics Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland; iCAN Digital Precision Cancer Medicine Flagship, Helsinki, Finland.

Juho Väänänen (J)

Applied Tumor Genomics Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

Taru Ilmarinen (T)

Department of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Markus Lilja (M)

Department of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Riku Katainen (R)

Applied Tumor Genomics Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.

Outi Monni (O)

Applied Tumor Genomics Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland; iCAN Digital Precision Cancer Medicine Flagship, Helsinki, Finland; Clinicum/Department of Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

Leena-Maija Aaltonen (LM)

Department of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

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Classifications MeSH

questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Tumeurs épidermoïdes › Carcinome épidermoïde › Exome sequencing reveals candidate mutations...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Carcinogenèse › Transformation cellulaire néoplasique › Exome sequencing reveals candidate mutations...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Exome › Exome sequencing reveals candidate mutations...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Exome sequencing reveals candidate mutations...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Exome sequencing reveals candidate mutations...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Tumeurs épidermoïdes › Papillome › Papillome inversé › Exome sequencing reveals candidate mutations...
questionsmedicales.fr › Maladies oto-rhino-laryngologiques › Tumeurs oto-rhino-laryngologiques › Tumeurs du nez › Tumeurs des sinus de la face › Exome sequencing reveals candidate mutations...
questionsmedicales.fr › Tumeurs › Tumeurs par siège › Tumeurs de la tête et du cou › Carcinome épidermoïde de la tête et du cou › Exome sequencing reveals candidate mutations...