Hydrogen Sulphide Release via the Angiotensin Converting Enzyme Inhibitor Zofenopril Prevents Intimal Hyperplasia in Human Vein Segments and in a Mouse Model of Carotid Artery Stenosis.
Angiotensin-Converting Enzyme Inhibitors
/ administration & dosage
Animals
Blood Pressure
/ drug effects
Captopril
/ administration & dosage
Carotid Arteries
/ drug effects
Carotid Stenosis
/ drug therapy
Cells, Cultured
Disease Models, Animal
Humans
Hydrogen Sulfide
/ metabolism
Hyperplasia
/ drug therapy
Hypertension
/ complications
Male
Mice
Myocytes, Smooth Muscle
Organ Culture Techniques
Primary Cell Culture
Tunica Intima
/ drug effects
Veins
/ drug effects
ACE inhibitor
Hydrogen sulphide
Hypertension
Intimal hyperplasia
Proliferation
Restenosis
Smooth muscle cells
Zofenopril
Journal
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery
ISSN: 1532-2165
Titre abrégé: Eur J Vasc Endovasc Surg
Pays: England
ID NLM: 9512728
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
received:
16
02
2021
revised:
01
09
2021
accepted:
17
09
2021
pubmed:
18
12
2021
medline:
8
3
2022
entrez:
17
12
2021
Statut:
ppublish
Résumé
Hypertension is a major risk factor for intimal hyperplasia (IH) and re-stenosis following vascular and endovascular interventions. Preclinical studies suggest that hydrogen sulphide (H Spontaneously hypertensive male Cx40 deleted mice (Cx40 Compared with control animals (intima/media thickness 2.3 ± 0.33 μm), enalapril reduced IH in Cx40 Zofenopril provides extra beneficial effects compared with non-sulfhydryl ACEi in reducing SMC proliferation and re-stenosis, even in normotensive animals. These findings may hold broad clinical implications for patients suffering from vascular occlusive diseases and hypertension.
Identifiants
pubmed: 34916111
pii: S1078-5884(21)00771-1
doi: 10.1016/j.ejvs.2021.09.032
pii:
doi:
Substances chimiques
Angiotensin-Converting Enzyme Inhibitors
0
zofenopril
290ZY759PI
Captopril
9G64RSX1XD
Hydrogen Sulfide
YY9FVM7NSN
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
336-346Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Conflict of interest None.