17β-Hydroxysteroid Dehydrogenase Type 1 Inhibition: A Potential Treatment Option for Non-Small Cell Lung Cancer.
Journal
ACS medicinal chemistry letters
ISSN: 1948-5875
Titre abrégé: ACS Med Chem Lett
Pays: United States
ID NLM: 101521073
Informations de publication
Date de publication:
09 Dec 2021
09 Dec 2021
Historique:
received:
27
08
2021
accepted:
11
11
2021
entrez:
17
12
2021
pubmed:
18
12
2021
medline:
18
12
2021
Statut:
epublish
Résumé
In the face of the clinical challenge posed by non-small cell lung cancer (NSCLC), the present need for new therapeutic approaches is genuine. Up to now, no proof existed that 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) is a viable target for treating this disease. Synthesis of a rationally designed library of 2,5-disubstituted furan derivatives followed by biological screening led to the discovery of 17β-HSD1 inhibitor
Identifiants
pubmed: 34917255
doi: 10.1021/acsmedchemlett.1c00462
pmc: PMC8667298
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1920-1924Informations de copyright
© 2021 American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare the following competing financial interest(s): A.S.A., C.J.v.K., S.M.-O., R.W.H., and M.F. are inventors of a US patent covering compounds 1-10 (US9884839(B2)).
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