Martin Frotscher

Affiliations

Pharmaceutical and Medicinal Chemistry, Saarland University, Campus C23, Saarbrücken, D-66123, Germany.

Publications (15)

A Hybrid In Silico/In Vitro Target Fishing Study to Mine Novel Targets of Urolithin A and B: A Step Towards a Better Comprehension of Their Estrogenicity.

Molecular nutrition & food research

Avec: Luca Dellafiora , Marco Milioli , Angela Falco , Margherita Interlandi , Abdelrahman Mohamed , Martin Frotscher , Benedetta Riccardi , Paola Puccini , Daniele Del Rio , Gianni Galaverna , Chiara Dall'Asta

Myosin V regulates synaptopodin clustering and localization in the dendrites of hippocampal neurons.

Journal of cell science

Avec: Anja Konietzny , Judit González-Gallego , Julia Bär , Alberto Perez-Alvarez , Alexander Drakew , Jeroen A A Demmers , Dick H W Dekkers , John A Hammer , Michael Frotscher , Thomas G Oertner , Wolfgang Wagner , Matthias Kneussel , Marina Mikhaylova

Inhibitors of 17β-hydroxysteroid dehydrogenase type 1, 2 and 14: Structures, biological activities and future challenges.

Molecular and cellular endocrinology

Avec: Mohamed Salah , Ahmed S Abdelsamie , Martin Frotscher

Selective Inactivation of Reelin in Inhibitory Interneurons Leads to Subtle Changes in the Dentate Gyrus But Leaves Cortical Layering and Behavior Unaffected.

Cerebral cortex (New York, N.Y. : 1991)

Avec: Jasmine Pahle , Mary Muhia , Robin J Wagener , Anja Tippmann , Hans H Bock , Janice Graw , Joachim Herz , Jochen F Staiger , Alexander Drakew , Matthias Kneussel , Gabriele M Rune , Michael Frotscher , Bianka Brunne

Correction: Reelin controls the positioning of brainstem serotonergic raphe neurons.

PloS one

Avec: Reham Shehabeldin , David Lutz , Meliha Karsak , Michael Frotscher , Kerstin Krieglstein , Ahmed Sharaf

Targeted Endocrine Therapy: Design, Synthesis, and Proof-of-Principle of 17β-Hydroxysteroid Dehydrogenase Type 2 Inhibitors in Bone Fracture Healing.

Journal of medicinal chemistry

Avec: Ahmed S Abdelsamie , Steven Herath , Yannik Biskupek , Carsten Börger , Lorenz Siebenbürger , Mohamed Salah , Claudia Scheuer , Sandrine Marchais-Oberwinkler , Martin Frotscher , Tim Pohlemann , Michael D Menger , Rolf W Hartmann , Matthias W Laschke , Chris J van Koppen

17β-Hydroxysteroid Dehydrogenase Type 1 Inhibition: A Potential Treatment Option for Non-Small Cell Lung Cancer.

ACS medicinal chemistry letters

Avec: Emanuele M Gargano , Abdelrahman Mohamed , Ahmed S Abdelsamie , Giuseppe F Mangiatordi , Hanna Drzewiecka , Paweł P Jagodziński , Arcangela Mazzini , Chris J van Koppen , Matthias W Laschke , Orazio Nicolotti , Angelo Carotti , Sandrine Marchais-Oberwinkler , Rolf W Hartmann , Martin Frotscher

Phosphorylation of Focal Adhesion Kinase at Y925: Role in Glia-Dependent and Independent Migration through Regulating Cofilin and N-Cadherin.

Molecular neurobiology

Avec: Lingzhen Song , Shanting Zhao , Michael Frotscher , Xuejun Chai

Potent Dual Inhibitors of Steroid Sulfatase and 17β-Hydroxysteroid Dehydrogenase Type 1 with a Suitable Pharmacokinetic Profile for

Journal of medicinal chemistry

Avec: Mohamed Salah , Mariam Tahoun , Jeannette Rudzitis-Auth , Lisa Stotz , Chris J van Koppen , Matthias W Laschke , Ahmed S Abdelsamie , Martin Frotscher

The Microtubule Severing Protein Katanin Regulates Proliferation of Neuronal Progenitors in Embryonic and Adult Neurogenesis.

Scientific reports

Avec: Franco L Lombino , Mary Muhia , Jeffrey Lopez-Rojas , Monika S Brill , Edda Thies , Laura Ruschkies , David Lutz , Melanie Richter , Torben J Hausrat , André T Lopes , Francis J McNally , Irm Hermans-Borgmeyer , Jessica E M Dunleavy , Sabine Hoffmeister-Ullerich , Michael Frotscher , Thomas Misgeld , Michael R Kreutz , Froylan Calderon de Anda , Matthias Kneussel

Design, Synthesis, and Biological Characterization of Orally Active 17β-Hydroxysteroid Dehydrogenase Type 2 Inhibitors Targeting the Prevention of Osteoporosis.

Journal of medicinal chemistry

Avec: Ahmed S Abdelsamie , Mohamed Salah , Lorenz Siebenbürger , Ahmed Merabet , Claudia Scheuer , Martin Frotscher , Sebastian T Müller , Oliver Zierau , Günter Vollmer , Michael D Menger , Matthias W Laschke , Chris J van Koppen , Sandrine Marchais-Oberwinkler , Rolf W Hartmann

Development of potential preclinical candidates with promising in vitro ADME profile for the inhibition of type 1 and type 2 17β-Hydroxysteroid dehydrogenases: Design, synthesis, and biological evaluation.

European journal of medicinal chemistry

Avec: Ahmed S Abdelsamie , Mohamed Salah , Lorenz Siebenbürger , Mostafa M Hamed , Carsten Börger , Chris J van Koppen , Martin Frotscher , Rolf W Hartmann

Differential modulation of short-term plasticity at hippocampal mossy fiber and Schaffer collateral synapses by mitochondrial Ca2.

PloS one

Avec: Sang Hun Lee , David Lutz , Dagmar Drexler , Michael Frotscher , Jie Shen

Dual Targeting of Steroid Sulfatase and 17β-Hydroxysteroid Dehydrogenase Type 1 by a Novel Drug-Prodrug Approach: A Potential Therapeutic Option for the Treatment of Endometriosis.

Journal of medicinal chemistry

Avec: Abdelrahman Mohamed , Mohamed Salah , Mariam Tahoun , Manuel Hawner , Ahmed S Abdelsamie , Martin Frotscher

The Digital Atlas of Ancient Rare Diseases (DAARD) and its relevance for current research.

Orphanet journal of rare diseases

Avec: Julia Gresky , Melina Frotscher , Juliane Dorn , Kristina Scheelen-Nováček , Yannick Ahlbrecht , Tina Jakob , Toni Schönbuchner , José Canalejo , Benjamin Ducke , Emmanuele Petiti

Réseau de co-auteurs

Ahmed S Abdelsamie 7 collaborations

Michael Frotscher 6 collaborations

Mohamed Salah 6 collaborations

Chris J van Koppen 5 collaborations

Rolf W Hartmann 4 collaborations

Matthias W Laschke 4 collaborations

Abdelrahman Mohamed 3 collaborations

Matthias Kneussel 3 collaborations

David Lutz 3 collaborations

Lorenz Siebenbürger 3 collaborations

Sandrine Marchais-Oberwinkler 3 collaborations

Alexander Drakew 2 collaborations

Mary Muhia 2 collaborations

Carsten Börger 2 collaborations

Claudia Scheuer 2 collaborations

Michael D Menger 2 collaborations

Mariam Tahoun 2 collaborations

Luca Dellafiora 1 collaboration

Marco Milioli 1 collaboration

Angela Falco 1 collaboration

Margherita Interlandi 1 collaboration

Benedetta Riccardi 1 collaboration

Paola Puccini 1 collaboration

Daniele Del Rio 1 collaboration

Gianni Galaverna 1 collaboration

Chiara Dall'Asta 1 collaboration

Anja Konietzny 1 collaboration

Judit González-Gallego 1 collaboration

Julia Bär 1 collaboration

Alberto Perez-Alvarez 1 collaboration

Jeroen A A Demmers 1 collaboration

Dick H W Dekkers 1 collaboration

John A Hammer 1 collaboration

Thomas G Oertner 1 collaboration

Wolfgang Wagner 1 collaboration

Marina Mikhaylova 1 collaboration

Jasmine Pahle 1 collaboration

Robin J Wagener 1 collaboration

Anja Tippmann 1 collaboration

Hans H Bock 1 collaboration

Janice Graw 1 collaboration

Joachim Herz 1 collaboration

Jochen F Staiger 1 collaboration

Gabriele M Rune 1 collaboration

Bianka Brunne 1 collaboration

Reham Shehabeldin 1 collaboration

Meliha Karsak 1 collaboration

Kerstin Krieglstein 1 collaboration

Ahmed Sharaf 1 collaboration

Steven Herath 1 collaboration

Yannik Biskupek 1 collaboration

Tim Pohlemann 1 collaboration

Emanuele M Gargano 1 collaboration

Giuseppe F Mangiatordi 1 collaboration

Hanna Drzewiecka 1 collaboration

Paweł P Jagodziński 1 collaboration

Arcangela Mazzini 1 collaboration

Orazio Nicolotti 1 collaboration

Angelo Carotti 1 collaboration

Lingzhen Song 1 collaboration

Shanting Zhao 1 collaboration

Xuejun Chai 1 collaboration

Jeannette Rudzitis-Auth 1 collaboration

Lisa Stotz 1 collaboration

Franco L Lombino 1 collaboration

Jeffrey Lopez-Rojas 1 collaboration

Monika S Brill 1 collaboration

Edda Thies 1 collaboration

Laura Ruschkies 1 collaboration

Melanie Richter 1 collaboration

Torben J Hausrat 1 collaboration

André T Lopes 1 collaboration

Francis J McNally 1 collaboration

Irm Hermans-Borgmeyer 1 collaboration

Jessica E M Dunleavy 1 collaboration

Sabine Hoffmeister-Ullerich 1 collaboration

Thomas Misgeld 1 collaboration

Michael R Kreutz 1 collaboration

Froylan Calderon de Anda 1 collaboration

Ahmed Merabet 1 collaboration

Sebastian T Müller 1 collaboration

Oliver Zierau 1 collaboration

Günter Vollmer 1 collaboration

Mostafa M Hamed 1 collaboration

Sang Hun Lee 1 collaboration

Dagmar Drexler 1 collaboration

Jie Shen 1 collaboration

Manuel Hawner 1 collaboration

Julia Gresky 1 collaboration

Melina Frotscher 1 collaboration

Juliane Dorn 1 collaboration

Kristina Scheelen-Nováček 1 collaboration

Yannick Ahlbrecht 1 collaboration

Tina Jakob 1 collaboration

Toni Schönbuchner 1 collaboration

José Canalejo 1 collaboration

Benjamin Ducke 1 collaboration

Emmanuele Petiti 1 collaboration