Selective Inactivation of Reelin in Inhibitory Interneurons Leads to Subtle Changes in the Dentate Gyrus But Leaves Cortical Layering and Behavior Unaffected.
Animals
Behavior, Animal
/ physiology
Cell Adhesion Molecules, Neuronal
/ metabolism
Cell Movement
/ physiology
Dentate Gyrus
/ metabolism
Extracellular Matrix Proteins
/ metabolism
Hippocampus
/ metabolism
Interneurons
/ drug effects
Mice, Inbred C57BL
Mice, Knockout
Neocortex
/ metabolism
Nerve Tissue Proteins
/ metabolism
Neurogenesis
/ physiology
Neurons
/ metabolism
Plant Leaves
/ metabolism
Reelin Protein
Serine Endopeptidases
/ metabolism
CB1
Calretinin
GFAP
adult neurogenesis
Journal
Cerebral cortex (New York, N.Y. : 1991)
ISSN: 1460-2199
Titre abrégé: Cereb Cortex
Pays: United States
ID NLM: 9110718
Informations de publication
Date de publication:
14 03 2020
14 03 2020
Historique:
pubmed:
2
11
2019
medline:
16
6
2021
entrez:
1
11
2019
Statut:
ppublish
Résumé
Reelin is an extracellular matrix protein, known for its dual role in neuronal migration during brain development and in synaptic plasticity at adult stages. During the perinatal phase, Reelin expression switches from Cajal-Retzius (CR) cells, its main source before birth, to inhibitory interneurons (IN), the main source of Reelin in the adult forebrain. IN-derived Reelin has been associated with schizophrenia and temporal lobe epilepsy; however, the functional role of Reelin from INs is presently unclear. In this study, we used conditional knockout mice, which lack Reelin expression specifically in inhibitory INs, leading to a substantial reduction in total Reelin expression in the neocortex and dentate gyrus. Our results show that IN-specific Reelin knockout mice exhibit normal neuronal layering and normal behavior, including spatial reference memory. Although INs are the major source of Reelin within the adult stem cell niche, Reelin from INs does not contribute substantially to normal adult neurogenesis. While a closer look at the dentate gyrus revealed some unexpected alterations at the cellular level, including an increase in the number of Reelin expressing CR cells, overall our data suggest that Reelin derived from INs is less critical for cortex development and function than Reelin expressed by CR cells.
Identifiants
pubmed: 31667489
pii: 5610048
doi: 10.1093/cercor/bhz196
pmc: PMC7132935
doi:
Substances chimiques
Cell Adhesion Molecules, Neuronal
0
Extracellular Matrix Proteins
0
Nerve Tissue Proteins
0
Reelin Protein
0
Reln protein, mouse
EC 3.4.21.-
Serine Endopeptidases
EC 3.4.21.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1688-1707Subventions
Organisme : NINDS NIH HHS
ID : R01 NS093382
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS108115
Pays : United States
Organisme : NHLBI NIH HHS
ID : R37 HL063762
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG053391
Pays : United States
Informations de copyright
© The Author(s) 2019. Published by Oxford University Press.
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