Impact of pharmacological interventions on anthropometric indices in women with polycystic ovary syndrome: A systematic review and meta-analysis of randomized controlled trials.
BMI
WC
WHR
body weight
pharmacological therapy
polycystic ovary syndrome (PCOS)
Journal
Clinical endocrinology
ISSN: 1365-2265
Titre abrégé: Clin Endocrinol (Oxf)
Pays: England
ID NLM: 0346653
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
revised:
11
12
2021
received:
29
10
2021
accepted:
14
12
2021
pubmed:
18
12
2021
medline:
6
5
2022
entrez:
17
12
2021
Statut:
ppublish
Résumé
Polycystic ovary syndrome (PCOS) is a heterogeneous condition affecting women of reproductive age and is associated with increased body weight. To review the literature on the effect of different pharmacological interventions on the anthropometric indices in women with PCOS. We searched PubMed, MEDLINE, Scopus, Embase, Cochrane library, and the Web of Science in April 2020 with an update in PubMed in March 2021. The study followed the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA)2020. Reviewers extracted data and assessed the risk of bias using the Cochrane risk of bias tool. 80 RCTs were included in the meta-analysis. Metformin vs placebo showed significant reduction in the mean body weight (MD: -3.13 kg; 95% confidence interval [CI]: -5.33 to -0.93, I² = 5%) and the mean body mass index (BMI) (MD: -0.75 kg/m Pharmacological interventions including metformin, sitagliptin, pioglitazone, rosiglitazone orlistat, and acarbose have significant effects on the anthropometric indices in women with PCOS.
Substances chimiques
Hypoglycemic Agents
0
Rosiglitazone
05V02F2KDG
Metformin
9100L32L2N
Orlistat
95M8R751W8
Acarbose
T58MSI464G
Pioglitazone
X4OV71U42S
Types de publication
Journal Article
Meta-Analysis
Review
Systematic Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
758-780Informations de copyright
© 2021 John Wiley & Sons Ltd.
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