Diversity in modern heart failure trials: Where are we, and where are we going.
Black
Cardiovascular clinical trials
Disparities
Journal
International journal of cardiology
ISSN: 1874-1754
Titre abrégé: Int J Cardiol
Pays: Netherlands
ID NLM: 8200291
Informations de publication
Date de publication:
01 02 2022
01 02 2022
Historique:
received:
04
10
2021
revised:
09
12
2021
accepted:
13
12
2021
pubmed:
18
12
2021
medline:
20
1
2022
entrez:
17
12
2021
Statut:
ppublish
Résumé
Over the last three decades, increased attention has been given to the representation of historically underrepresented groups within the landscape of pivotal clinical trials. However, recent events (i.e., coronavirus pandemic) have laid bare the potential continuation of historic inequities in available clinical trials and studies aimed at the care of broad patient populations. Anecdotally, cardiovascular disease (CVD) has not been immune to these disparities. Within this review, we examine and discuss recent landmark CVD trials, with a specific focus on the representation of Blacks within several critically foundational heart failure clinical trials tied to contemporary treatment strategies and drug approvals. We also discuss solutions for inequities within the landscape of cardiovascular trials. Building a more diverse clinical trial workforce coupled with intentional efforts to increase clinical trial diversity will advance equity in cardiovascular care.
Identifiants
pubmed: 34920047
pii: S0167-5273(21)02010-6
doi: 10.1016/j.ijcard.2021.12.018
pmc: PMC9023064
mid: NIHMS1796812
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
95-101Subventions
Organisme : NIDDK NIH HHS
ID : K23 DK117041
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL110837
Pays : United States
Informations de copyright
Copyright © 2021. Published by Elsevier B.V.
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