Clinical impact of a gastrointestinal PCR panel in children with infectious diarrhoea.
gastroenterology
infectious disease medicine
microbiology
molecular biology
paediatrics
Journal
Archives of disease in childhood
ISSN: 1468-2044
Titre abrégé: Arch Dis Child
Pays: England
ID NLM: 0372434
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
received:
15
05
2021
accepted:
28
11
2021
pubmed:
19
12
2021
medline:
24
5
2022
entrez:
18
12
2021
Statut:
ppublish
Résumé
Multiplex gastrointestinal PCR (GI-PCR) allows fast and simultaneous detection of 22 enteric pathogens (including All children eligible for stool culture from May to October 2018 were prospectively included in a monocentric study at Robert-Debré University-Hospital. A GI-PCR (BioFire FilmArray) was performed on each stool sample. Data on the children's healthcare management before and after GI-PCR results were collected. Stool culture results were also reported. 172 children were included. The main criteria for performing stool analysis were mucous/bloody diarrhoea and/or traveller's diarrhoea (n=130). GI-PCR's were positive for 120 patients (70%). The main pathogens were enteroaggregative The GI-PCR's results impacted the medical management of gastroenteritis for almostone-fourth of the children, and especially the prescription of appropriate antibiotic treatment before stool culture results.
Identifiants
pubmed: 34921002
pii: archdischild-2021-322465
doi: 10.1136/archdischild-2021-322465
doi:
Substances chimiques
Anti-Bacterial Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
601-605Informations de copyright
© Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.