Transcriptional network orchestrating regional patterning of cortical progenitors.

Animals COUP Transcription Factor I / metabolism Cerebral Cortex / embryology Epigenome Gene Regulatory Networks Homeodomain Proteins / metabolism LIM-Homeodomain Proteins / metabolism Mice PAX6 Transcription Factor / metabolism Pre-B-Cell Leukemia Transcription Factor 1 / metabolism Regulatory Elements, Transcriptional Transcription Factors / genetics
cortical patterning epigenetics progenitor cells transcription factors

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
21 12 2021
Historique:
accepted: 25 10 2021
entrez: 18 12 2021
pubmed: 19 12 2021
medline: 14 1 2022
Statut: ppublish

Résumé

We uncovered a transcription factor (TF) network that regulates cortical regional patterning in radial glial stem cells. Screening the expression of hundreds of TFs in the developing mouse cortex identified 38 TFs that are expressed in gradients in the ventricular zone (VZ). We tested whether their cortical expression was altered in mutant mice with known patterning defects (

Identifiants

DOI: 10.1073/pnas.2024795118 PMID: 34921112 PMC: PMC8713794
pubmed: 34921112
pii: 2024795118
doi: 10.1073/pnas.2024795118
pmc: PMC8713794
pii:
doi:

Substances chimiques

COUP Transcription Factor I 0
Homeodomain Proteins 0
LIM-Homeodomain Proteins 0
Lhx2 protein, mouse 0
Nr2f1 protein, mouse 0
PAX6 Transcription Factor 0
Pax6 protein, mouse 0
Pbx1 protein, mouse 0
Pre-B-Cell Leukemia Transcription Factor 1 0
Transcription Factors 0
empty spiracles homeobox proteins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NHGRI NIH HHS
ID : R01 HG003988
Pays : United States
Organisme : NIDDK NIH HHS
ID : U54 DK107977
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA082103
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM119831
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS034661
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS099099
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH049428
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007175
Pays : United States
Organisme : NIMH NIH HHS
ID : R37 MH049428
Pays : United States

Informations de copyright

Copyright © 2021 the Author(s). Published by PNAS.

Déclaration de conflit d'intérêts

Competing interest statement: J.L.R. is a cofounder, stockholder, and currently on the scientific board of Neurona, a company studying the potential therapeutic use of interneuron transplantation.

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Auteurs

Athéna R Ypsilanti (AR)

Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, CA 94158; athena.ypsilanti@ucsf.edu john.rubenstein@ucsf.edu.
ORCID: 0000-0002-0310-7693

Kartik Pattabiraman (K)

Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, CA 94158.
ORCID: 0000-0002-3924-426X

Rinaldo Catta-Preta (R)

Department of Neurobiology, Physiology and Behavior, University of California, Davis, CA 95618.
Department of Psychiatry and Behavioral Sciences, University of California, Davis, CA 95618.
ORCID: 0000-0001-9833-1278

Olga Golonzhka (O)

Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, CA 94158.

Susan Lindtner (S)

Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, CA 94158.

Ke Tang (K)

Precise Genome Engineering Center, School of Life Sciences, Guangzhou University, Guangzhou 510006, China.
ORCID: 0000-0002-0516-4667

Ian R Jones (IR)

Institute for Human Genetics, University of California, San Francisco, CA 94143.
Department of Neurology, University of California, San Francisco, CA 94143.

Armen Abnousi (A)

Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195.

Ivan Juric (I)

Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195.

Ming Hu (M)

Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195.
ORCID: 0000-0003-0987-2916

Yin Shen (Y)

Institute for Human Genetics, University of California, San Francisco, CA 94143.
Department of Neurology, University of California, San Francisco, CA 94143.

Diane E Dickel (DE)

Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.

Axel Visel (A)

Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.
School of Natural Sciences, University of California, Merced, CA 95343.
US Department of Energy Joint Genome Institute, Berkeley, CA 94720.

Len A Pennachio (LA)

Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.
US Department of Energy Joint Genome Institute, Berkeley, CA 94720.
Comparative Biochemistry Program, University of California, Berkeley, CA 94720.

Michael Hawrylycz (M)

Allen Institute for Brain Science, Seattle, WA 98109.

Carol L Thompson (CL)

Allen Institute for Brain Science, Seattle, WA 98109.
ORCID: 0000-0003-1528-3237

Hongkui Zeng (H)

Allen Institute for Brain Science, Seattle, WA 98109.
ORCID: 0000-0002-0326-5878

Iros Barozzi (I)

Faculty of Medicine, Department of Surgery and Cancer, Imperial College, London SW7 2AZ, United Kingdom.
ORCID: 0000-0003-0690-3473

Alex S Nord (AS)

Department of Neurobiology, Physiology and Behavior, University of California, Davis, CA 95618.
Department of Psychiatry and Behavioral Sciences, University of California, Davis, CA 95618.
ORCID: 0000-0003-4259-7514

John L Rubenstein (JL)

Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, CA 94158; athena.ypsilanti@ucsf.edu john.rubenstein@ucsf.edu.
ORCID: 0000-0002-4414-7667

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Transcriptional network orchestrating regional...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Facteur de transcription COUP-TFI › Transcriptional network orchestrating regional...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Transcriptional network orchestrating regional...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Épigénome › Transcriptional network orchestrating regional...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Séquences d'acides nucléiques régulatrices › Réseaux de régulation génique › Transcriptional network orchestrating regional...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de liaison à l'ADN › Protéines à homéodomaine › Transcriptional network orchestrating regional...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines à domaine LIM › Protéines à homéodomaine LIM › Transcriptional network orchestrating regional...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Transcriptional network orchestrating regional...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription PAX › Facteur de transcription PAX6 › Transcriptional network orchestrating regional...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteur de transcription-1 de la leucémie pré-B › Transcriptional network orchestrating regional...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Éléments de régulation transcriptionnelle › Transcriptional network orchestrating regional...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Transcriptional network orchestrating regional...