Can activated titanium interbody cages accelerate or enhance spinal fusion? a review of the literature and a design for clinical trials.
Journal
Journal of materials science. Materials in medicine
ISSN: 1573-4838
Titre abrégé: J Mater Sci Mater Med
Pays: United States
ID NLM: 9013087
Informations de publication
Date de publication:
18 Dec 2021
18 Dec 2021
Historique:
received:
07
07
2021
accepted:
16
11
2021
entrez:
18
12
2021
pubmed:
19
12
2021
medline:
25
3
2022
Statut:
epublish
Résumé
While spinal interbody cage options have proliferated in the past decade, relatively little work has been done to explore the comparative potential of biomaterial technologies in promoting stable fusion. Innovations such as micro-etching and nano-architectural designs have shown purported benefits in in vitro studies, but lack clinical data describing their optimal implementation. Here, we critically assess the pre-clinical data supportive of various commercially available interbody cage biomaterial, topographical, and structural designs. We describe in detail the osteointegrative and osteoconductive benefits conferred by these modifications with a focus on polyetheretherketone (PEEK) and titanium (Ti) interbody implants. Further, we describe the rationale and design for two randomized controlled trials, which aim to address the paucity of clinical data available by comparing interbody fusion outcomes between either PEEK or activated Ti lumbar interbody cages. Utilizing dual-energy computed tomography (DECT), these studies will evaluate the relative implant-bone integration and fusion rates achieved by either micro-etched Ti or standard PEEK interbody devices. Taken together, greater understanding of the relative osseointegration profile at the implant-bone interface of cages with distinct topographies will be crucial in guiding the rational design of further studies and innovations.
Identifiants
pubmed: 34921610
doi: 10.1007/s10856-021-06628-1
pii: 10.1007/s10856-021-06628-1
pmc: PMC8684547
doi:
Substances chimiques
Bone Substitutes
0
Coated Materials, Biocompatible
0
Titanium
D1JT611TNE
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1Informations de copyright
© 2021. The Author(s).
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