Antagonist of growth hormone-releasing hormone MIA-690 attenuates the progression and inhibits growth of colorectal cancer in mice.

Animals Male Mice Apoptosis / drug effects Carcinogenesis / drug effects Cell Proliferation / drug effects Colorectal Neoplasms / metabolism Down-Regulation Growth Hormone-Releasing Hormone / antagonists & inhibitors Inflammation Mediators / metabolism Mice, Inbred C57BL Oxidative Stress / drug effects Random Allocation Up-Regulation
Apoptotic pathways Colorectal cancer Growth hormone-releasing hormone antagonist Inflammation Oncogenic pathways Oxidative stress

Journal

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
ISSN: 1950-6007
Titre abrégé: Biomed Pharmacother
Pays: France
ID NLM: 8213295

Informations de publication

Date de publication:
Feb 2022
Historique:
received: 19 11 2021
revised: 09 12 2021
accepted: 13 12 2021
pubmed: 20 12 2021
medline: 22 3 2022
entrez: 19 12 2021
Statut: ppublish

Résumé

Colorectal cancer (CRC) is an aggressive tumor in which new treatment options deliver negative results on cure rates and long-term survival. The anticancer effects of growth hormone-releasing hormone (GHRH) antagonists have been reported in various experimental tumors, but their activity in CRC is unknown. In the present study, we demonstrated that chronic treatment with GHRH antagonist of MIAMI class, MIA-690, promoted survival and gradually blunted tumor progression in experimentally induced colitis-associated cancer in mice, paralleled by reduced inflammation in colon tissue. In particular, MIA-690 improved disease activity index score, and reduced loss of weight and mortality, by improving the survival rates, compared with vehicle-treated group. MIA-690 was also found to reduce various inflammatory and oxidative markers, such as serotonin, prostaglandin (PG)E

Identifiants

DOI: 10.1016/j.biopha.2021.112554 PMID: 34923341
pubmed: 34923341
pii: S0753-3322(21)01341-X
doi: 10.1016/j.biopha.2021.112554
pii:
doi:

Substances chimiques

Growth Hormone-Releasing Hormone 9034-39-3
Inflammation Mediators 0
MIA-690 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

112554

Subventions

Organisme : BLRD VA
ID : I01 BX005051
Pays : United States

Informations de copyright

Copyright © 2021 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

Auteurs

Lucia Recinella (L)

Department of Pharmacy, G. d'Annunzio University of Chieti-Pescara, 66013 Chieti, Italy. Electronic address: lucia.recinella@unich.it.

Annalisa Chiavaroli (A)

Department of Pharmacy, G. d'Annunzio University of Chieti-Pescara, 66013 Chieti, Italy. Electronic address: annalisa.chiavaroli@unich.it.

Serena Veschi (S)

Department of Pharmacy, G. d'Annunzio University of Chieti-Pescara, 66013 Chieti, Italy. Electronic address: veschi@unich.it.

Valentina Di Valerio (V)

Department of Medicine and Ageing Sciences, G. d'Annunzio University of Chieti-Pescara, 66013 Chieti, Italy. Electronic address: valentina.divalerio@unich.it.

Rossano Lattanzio (R)

Department of Medical, Oral and Biotechnological Sciences, G. d'Annunzio University of Chieti-Pescara, 66013 Chieti, Italy; Center for Advanced Studies and Technology (CAST), G. d'Annunzio University of Chieti-Pescara, 66013 Chieti, Italy. Electronic address: rossano.lattanzio@unich.it.

Giustino Orlando (G)

Department of Pharmacy, G. d'Annunzio University of Chieti-Pescara, 66013 Chieti, Italy. Electronic address: giustino.orlando@unich.it.

Claudio Ferrante (C)

Department of Pharmacy, G. d'Annunzio University of Chieti-Pescara, 66013 Chieti, Italy. Electronic address: claudio.ferrante@unich.it.

Iacopo Gesmundo (I)

Division of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin, 10126 Turin, Italy. Electronic address: iacopo.gesmundo@unito.it.

Riccarda Granata (R)

Division of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin, 10126 Turin, Italy. Electronic address: riccarda.granata@unito.it.

Renzhi Cai (R)

Veterans Affairs Medical Center, Miami, FL 33125, USA; Division of Endocrinology, Diabetes and Metabolism, and Division of Medical Oncology, Department of Medicine, and Department of Pathology, Miller School of Medicine, University of Miami, and Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA. Electronic address: renzhi.c@hotmail.com.

Wei Sha (W)

Veterans Affairs Medical Center, Miami, FL 33125, USA; Division of Endocrinology, Diabetes and Metabolism, and Division of Medical Oncology, Department of Medicine, and Department of Pathology, Miller School of Medicine, University of Miami, and Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA. Electronic address: wei.sha@va.gov.

Andrew V Schally (AV)

Veterans Affairs Medical Center, Miami, FL 33125, USA; Division of Endocrinology, Diabetes and Metabolism, and Division of Medical Oncology, Department of Medicine, and Department of Pathology, Miller School of Medicine, University of Miami, and Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA. Electronic address: andrew.schally@va.gov.

Luigi Brunetti (L)

Department of Pharmacy, G. d'Annunzio University of Chieti-Pescara, 66013 Chieti, Italy. Electronic address: luigi.brunetti@unich.it.

Sheila Leone (S)

Department of Pharmacy, G. d'Annunzio University of Chieti-Pescara, 66013 Chieti, Italy. Electronic address: sheila.leone@unich.it.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Antagonist of growth hormone-releasing hormone...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Antagonist of growth hormone-releasing hormone...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Antagonist of growth hormone-releasing hormone...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Carcinogenèse › Antagonist of growth hormone-releasing hormone...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Antagonist of growth hormone-releasing hormone...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies du rectum › Tumeurs colorectales › Antagonist of growth hormone-releasing hormone...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Régulation négative › Antagonist of growth hormone-releasing hormone...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Neuropeptides › Hormones hypothalamiques › Hormones hypophysiotropes libératrices › Hormone de libération de l'hormone de croissance › Antagonist of growth hormone-releasing hormone...
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Antagonist of growth hormone-releasing hormone...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Antagonist of growth hormone-releasing hormone...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Antagonist of growth hormone-releasing hormone...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Répartition aléatoire › Antagonist of growth hormone-releasing hormone...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Régulation positive › Antagonist of growth hormone-releasing hormone...