Immune mechanisms in human Sarcoptes scabiei (Acari: Sarcoptidae) infestations.
Sarcoptes scabiei
adaptive immune response
innate immune response
scabies
Journal
Parasite immunology
ISSN: 1365-3024
Titre abrégé: Parasite Immunol
Pays: England
ID NLM: 7910948
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
revised:
14
12
2021
received:
09
09
2021
accepted:
15
12
2021
pubmed:
20
12
2021
medline:
26
3
2022
entrez:
19
12
2021
Statut:
ppublish
Résumé
Scabies is a parasitic infestation of human and animal skin caused by different strains of the itch mite, Sarcoptes scabiei. The World Health Organization (WHO) has declared scabies in human as a neglected tropical disease, and today over 200 million people worldwide are affected. The two most commonly reported clinical manifestation of the condition are ordinary (OS) and crusted scabies (CS). CS, which can lead to fatal consequences due to secondary bacterial infections, is mostly observed in immunocompromised subjects but can also, although rarely, be detected in immunocompetent individuals. Innate and adaptive immune system components are involved in protection and pathogenesis of scabies, although with some differences between OS and CS. While the cutaneous immune response is dominated by CD4
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12900Informations de copyright
© 2021 John Wiley & Sons Ltd.
Références
WHO - World Health Organization. Scabies. https://www.who.int/news-room/fact-sheets/detail/scabies
Karimkhani C, Colombara DV, Drucker AM, et al. The global burden of scabies: a cross-sectional analysis from the Global Burden of Disease Study 2015. Lancet Infect Dis. 2017;17(12):1247-1254. doi:10.1016/S1473-3099(17)30483-8
Romani L, Steer AC, Whitfeld MJ, Kaldor JM. Prevalence of scabies and impetigo worldwide: a systematic review. Lancet Infect Dis. 2015;15(8):960-967. doi:10.1016/S1473-3099(15)00132-2
Chandler DJ, Fuller LC. A review of scabies: an infestation more than skin deep. Dermatology. 2019;235(2):79-80. doi:10.1159/000495290
Levi A, Mumcuoglu KY, Ingber A, Enk CD. Detection of living Sarcoptes scabiei larvae by reflectance mode confocal microscopy in the skin of a patient with crusted scabies. J Biomed Optics. 2012;17(6): 060503. doi:10.1117/1.jbo.17.6.060503
Mumcuoglu KY, Gilead L, Ingber A. New insights in pediculosis and scabies. Expert Review of Dermatology. 2009;4(3):285-302. doi:10.1586/edm.09.18
Bhat SA, Mounsey KE, Liu X, Walton SF. Host immune responses to the itch mite, Sarcoptes scabiei, in humans. Parasites & Vectors. 2017;10(1):385. doi:10.1186/s13071-017-2320-4
Walton SF. The immunology of susceptibility and resistance to scabies. Parasite Immunol. 2010;32(8):532-540. doi:10.1111/j.1365-3024.2010.01218.x
Quaresma JAS. Organization of the skin immune system and compartmentalized immune responses in infectious diseases. Clin Microbiol Rev. 2019;32(4). doi:10.1128/CMR.00034-18
Cruz MS, Diamond A, Russell A, Jameson JM. Human αβ and γδ T cells in skin immunity and disease. Front Immunol. 2018;9(Jun): doi:10.3389/fimmu.2018.01304
Merle NS, Noe R, Halbwachs-Mecarelli L, Fremeaux-Bacchi V, Roumenina LT. Complement system part II: Role in immunity. Front Immunol. 2015;6(May): doi:10.3389/fimmu.2015.00257
Yanez DA, Lacher RK, Vidyarthi A, Colegio OR. The role of macrophages in skin homeostasis. Pflugers Arch. 2017;469(3-4):455-463. doi:10.1007/s00424-017-1953-7
Clayton K, Vallejo AF, Davies J, Sirvent S, Polak ME. Langerhans cells-programmed by the epidermis. Front Immunol. 2017;44(Nov): doi:10.3389/fimmu.2017.01676
Inclan-Rico JM, Siracusa MC. First responders: innate immunity to helminths. Trends Parasitol. 2018;34(10):861-880. doi:10.1016/j.pt.2018.08.007
Haase P, Voehringer D. Regulation of the humoral type 2 immune response against allergens and helminths. Eur J Immunol. 2021;51(2):273-279. doi:10.1002/eji.202048864
Logan E, Chetty A, Horsnell WG. The role of antibody in parasitic helminth infections. Adv Exp Med Biol. 2014;828: doi:10.1007/978-1-4939-1489-0_1
Mukai K, Tsai M, Starkl P, Marichal T, Galli SJ. IgE and mast cells in host defense against parasites and venoms. Semin Immunopathol. 2016;38(5):581-603. doi:10.1007/s00281-016-0565-1
Gazi U, Taylan OA. Immune response and its effects on the host during helminthic infections. Eur J Therapeut. 2020;26(1):6-10. doi:10.5152/eurjther.2019.18078
Li Y, Jin L, Chen T, Pirozzi CJ. The effects of secretory IgA in the mucosal immune system. Biomed Res Int. 2020;2020:1-6. doi:10.1155/2020/2032057
Vanalli C, Mari L, Righetto L, Casagrandi R, Gatto M, Cattadori IM. Within-host mechanisms of immune regulation explain the contrasting dynamics of two helminth species in both single and dual infections. PLoS Comput Biol. 2020;16(11): doi:10.1371/journal.pcbi.1008438
Mika A, Goh P, Holt DC, Kemp DJ, Fischer K. Scabies mite peritrophins are potential targets of human host innate immunity. PLoS Negl Trop Dis. 2011;5(9): doi:10.1371/journal.pntd.0001331
Salo OP, Reunala T, Kalimo K, Rantanen T. Immunoglobulin and complement deposits in the skin and circulating immune complexes in scabies. Acta Dermato-Venereol. 1982;62(1):73-76.
Frentz G, Veien NK, Eriksen K. Immunofluorescence studies in scabies. J Cutan Pathol. 1977;4(4):191-193. doi:10.1111/j.1600-0560.1977.tb00907.x
Abreu-Velez AM, Klein AD, Howard MS. Autoreactivity to sweat glands and nerves in clinical scabies infection. North Am J Med Sci. 2010;2(1):42-425.
Arlian LG, Morgan MS, Vyszenskimoher DL, Stemmer BL. Sarcoptes scabiei: the circulating antibody response and induced immunity to scabies. Exp Parasitol. 1994;78(1):37-50. doi:10.1006/expr.1994.1004
Falk ES. Serum immunoglobulin values in patients with scabies. Br J Dermatol. 1980;102(1):57-61. doi:10.1111/j.1365-2133.1980.tb05672.x
Guillot B, Guilhou JJ, Clot J, Meynadier J. [Circulating immune complexes in skin disease patients. Study and literature data (author’s transl)]. Ann de Dermatol et de Venereol. 1981;108(10):741-749. ; https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med2&AN=7305215https://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:medline&id=pmid:7305215&id=doi:&issn=0151-9638&isbn=&volume=108&issue=10&spage=741&pages=741-9&date=1981&title=An
Nassef NE, Makled KM, Elzayat EA, Sanad MM. Humoral and cell mediated immune responses in scabietic patients. J Egypt Soc Parasitol. 1991;21(3):765-770.
Morsy TA, Kenawi MZ, Zohdy HA, Abdalla KF, el Fakahany AF. Serum immunoglobulin and complement values in scabietic patients. J Egypt Soc Parasitol. 1993;23(1):221-229.
Bergström FC, Reynolds S, Johnstone M, et al. Scabies mite inactivated serine protease paralogs inhibit the human complement system. J Immunol. 2009;182(12):7809-7817. doi:10.4049/jimmunol.0804205
Mika A, Reynolds SL, Mohlin FC, et al. Novel scabies mite serpins inhibit the three pathways of the human complement system. PLoS One. 2012;7(7): doi:10.1371/journal.pone.0040489
Reynolds SL, Pike RN, Mika A, et al. Scabies mite inactive serine proteases are potent inhibitors of the human complement lectin pathway. PLoS Negl Trop Dis. 2014;44(5): doi:10.1371/journal.pntd.0002872
Swe PM, Fischer K. A scabies mite serpin interferes with complement-mediated neutrophil functions and promotes staphylococcal growth. PLoS Negl Trop Dis. 2014;44(6): doi:10.1371/journal.pntd.0002928
Swe PM, Christian LD, Lu HC, Sriprakash KS, Fischer K. Complement inhibition by Sarcoptes scabiei protects Streptococcus pyogenes - an in vitro study to unravel the molecular mechanisms behind the poorly understood predilection of S. pyogenes to infect mite-induced skin lesions. PLoS Negl Trop Dis. 2017;11(3): doi:10.1371/journal.pntd.0005437
Mika A, Reynolds SL, Pickering D, et al. Complement inhibitors from scabies mites promote streptococcal growth - a novel mechanism in infected epidermis? PLoS Negl Trop Dis. 2012;6(7): doi:10.1371/journal.pntd.0001563
Bhat SA, Walton SF, Ventura T, et al. Early immune suppression leads to uncontrolled mite proliferation and potent host inflammatory responses in a porcine model of crusted versus ordinary scabies. PLoS Negl Trop Dis. 2020;14(9):1-28. doi:10.1371/journal.pntd.0008601
Walton SF, Beroukas D, Roberts-Thomson P, Currie BJ. New insights into disease pathogenesis in crusted (Norwegian) scabies: the skin immune response in crusted scabies. Br J Dermatol. 2008;158(6):1247-1255. doi:10.1111/j.1365-2133.2008.08541.x
Arlian LG, Rapp CM, Vyszenski-Moher DL, Morgan MS. Sarcoptes scabiei: histopathological changes associated with acquisition and expression of host immunity to scabies. Exp Parasitol. 1994;78(1):51-63. doi:10.1006/expr.1994.1005
Cote NM, Jaworski DC, Wasala NB, Morgan MS, Arlian LG. Identification and expression of macrophage migration inhibitory factor in Sarcoptes scabiei. Exp Parasitol. 2013;135(1):175-181. doi:10.1016/j.exppara.2013.06.012
Nwufoh OC, Sadiq NA, Adediran OA, Jarikre TA, Emikpe BO. Sequential histopathological changes and cytokine expressions in dogs naturally infested with Sarcoptes scabiei mites. Acta Parasitol. 2020;65(2):452-461. doi:10.2478/s11686-020-00181-7
Hashimoto T, Satoh T, Yokozeki H. Pruritus in ordinary scabies: IL-31 from macrophages induced by overexpression of thymic stromal lymphopoietin and periostin. Allergy. 2019;74(9):1727-1737. doi:10.1111/all.13870
Arlian LG, Morgan MS, Neal JS. Extracts of scabies mites (Sarcoptidae: Sarcoptes scabiei) modulate cytokine expression by human peripheral blood mononuclear cells and dendritic cells. J Med Entomol. 2004;41(1):69-73. doi:10.1603/0022-2585-41.1.69
Stemmer BL, Arlian LG, Morgan MS, Rapp CM, Moore PF. Characterization of antigen presenting cells and T-cells in progressing scabietic skin lesions. Vet Parasitol. 1996;67(3-4):247-258. doi:10.1016/S0304-4017(96)01038-2
Arlian LG, Fall N, Morgan MS. In vivo evidence that Sarcoptes scabiei (acari: Sarcoptidae) is the source of molecules that modulate splenic gene expression. J Med Entomol. 2007;44(6):1054-1063. doi:10.1603/0022-2585(2007)44[1054:IVETSS]2.0.CO;2
Elwood H, Berry RS, Gardner JM, Shalin SC. Superficial fibrin thrombi … and other findings: a review of the histopathology of human scabietic infections. J Cutan Pathol. 2015;42(5):346-352. doi:10.1111/cup.12482
Arlian LG, Morgan MS, Rapp CM, Vyszenski-Moher DAL. The development of protective immunity in canine scabies. Vet Parasitol. 1996;62(1-2):133-142. doi:10.1016/0304-4017(95)00854-3
Falk ES, Matre R. In situ characterization of cell infiltrates in the dermis of human scabies. Am J Dermatopathol. 1982;4(1):9-15. doi:10.1097/00000372-198202000-00003
Sharaf M, Antonios S, Mina S, Eliwa K, Rayia DA. The scabicide effect of moxidectin in vitro and in experimental animals: parasitological, histopathological and immunological evaluation. Exp Parasitol. 2020;217:107961. doi:10.1016/j.exppara.2020.107961
Espinosa J, Ráez-Bravo A, López-Olvera JR, et al. Histopathology, microbiology and the inflammatory process associated with Sarcoptes scabiei infection in the Iberian ibex, Capra pyrenaica. Parasites and Vectors. 2017;10(1): doi:10.1186/s13071-017-2542-5
Shrestha A, Bischof E. Crusted scabies induced hypereosinophilic syndrome. Cureus. 2021; doi:10.7759/cureus.15201
Ohnmacht C, Schwartz C, Panzer M, Schiedewitz I, Naumann R, Voehringer D. Basophils orchestrate chronic allergic dermatitis and protective immunity against helminths. Immunity. 2010;33(3):364-374. doi:10.1016/j.immuni.2010.08.011
Ito Y, Satoh T, Takayama K, Miyagishi C, Walls AF, Yokozeki H. Basophil recruitment and activation in inflammatory skin diseases. Allergy. 2011;66(8):1107-1113. doi:10.1111/j.1398-9995.2011.02570.x
Amer M, Mostafa FF, Nasr AN, El-Harras M. The role of mast cells in treatment of scabies. Int J Dermatol. 1995;34(3):186-189. doi:10.1111/j.1365-4362.1995.tb01564.x
Mounsey KE, Murray HC, Bielefeldt-Ohmann H, et al. Prospective study in a porcine model of sarcoptes scabiei indicates the association of Th2 and Th17 pathways with the clinical severity of scabies. PLoS Negl Trop Dis. 2015;9(3): doi:10.1371/journal.pntd.0003498
Skerratt LF. Cellular response in the dermis of common wombats (Vombatus ursinus) infected with Sarcoptes scabiei var. wombati. J Wildl Dis. 2003;39(1):193-202. doi:10.7589/0090-3558-39.1.193
Mullins JS, Arlian LG, Morgan MS. Extracts of Sarcoptes scabiei De Geer downmodulate secretion of IL-8 by skin keratinocytes and fibroblasts and of GM-CSF by fibroblasts in the presence of proinflammatory cytokines. J Med Entomol. 2009;46(4):845-851. doi:10.1603/033.046.0415
Morgan MS, Arlian LG, Markey MP. Sarcoptes scabiei mites modulate gene expression in human skin equivalents. PLoS One. 2013;44(8): doi:10.1371/journal.pone.0071143
Elder BL, Arlian LG, Morgan MS. Sarcoptes scabiei (Acari: Sarcoptidae) mite extract modulates expression of cytokines and adhesion molecules by human dermal microvascular endothelial cells. J Med Entomol. 2006;43(5):910-915. doi:10.1603/0022-2585(2006)43[910:SSASME]2.0.CO;2
Elder BL, Arlian LG, Morgan MS. Modulation of human dermal microvascular endothelial cells by Sarcoptes scabiei in combination with proinflammatory cytokines, histamine, and lipid-derived biologic mediators. Cytokine. 2009;47(2):103-111. doi:10.1016/j.cyto.2009.05.008
Salavastru CM, Chosidow O, Boffa MJ, Janier M, Tiplica GS. European guideline for the management of scabies. J Eur Acad Dermatol Venereol. 2017;31(8):1248-1253. doi:10.1111/jdv.14351
Arlian LG, Rapp CM, Stemmer BL, Morgan MS, Moore PF. Characterization of lymphocyte subtypes in scabietic skin lesions of naive and sensitized dogs. Vet Parasitol. 1997;68(4):347-358. doi:10.1016/S0304-4017(96)01093-X
Liu X, Walton SF, Murray HC, et al. Crusted scabies is associated with increased IL-17 secretion by skin T cells. Parasite Immunol. 2014;36(11):594-604. doi:10.1111/pim.12129
Lalli PN, Morgan MS, Arlian LG. Skewed TH1/TH2 immune response to Sarcoptes scabiei. J Parasitol. 2004;90(4):711-714. doi:10.1645/GE-214R
Walton SF, Pizzutto S, Slender A, et al. Increased allergic immune response to Sarcoptes scabiei antigens in crusted versus ordinary scabies. Clin Vaccine Immunol. 2010;17(9):1428-1438. doi:10.1128/CVI.00195-10
Singh SK, Dimri U, Sharma B, Saxena M, Kumari P. Assessment of the cytokine profile in peripheral blood mononuclear cells of naturally Sarcoptes scabiei var. canis infested dogs. Vet Parasitol. 2014;206(3-4):253-257. doi:10.1016/j.vetpar.2014.10.024
Arlian LG, Morgan MS, Paul CC. Evidence that scabies mites (Acari: Sarcoptidae) influence production of interleukin-10 and the function of T-regulatory cells (Tr1) in humans. J Med Entomol. 2006;43(2):283-287. doi:10.1603/0022-2585(2006)043[0283:etsmas]2.0.co;2
Rizki SM, Suwanti LT, Retno Lastuti ND. Histochemical expression of transforming growth factor beta and tumor necrosis factor alpha in rabbits (Oryctolagus Cuniculus) (Mammalia: Lagomorpha: Leporidae) infected with sarcoptes scabiei (Arachnida: Acari: Sarcoptidae). Philippine. Journal of Veterinary Medicine. 2018;55(Special Issue):43-50.
Zhang S. The role of transforming growth factor β in T helper 17 differentiation. Immunology. 2018;155(1):24-35. doi:10.1111/imm.12938
Zhu L, Hua F, Ding W, Ding K, Zhang Y, Xu C. The correlation between the Th17/Treg cell balance and bone health. Immun Age. 2020;17(1): doi:10.1186/s12979-020-00202-z
Roberts LJ, Huffam SE, Walton SF, Currie BJ. Crusted scabies: clinical and immunological findings in seventy-eight patients and a review of the literature. J Infect. 2005;50(5):375-381. doi:10.1016/j.jinf.2004.08.033
Morsy TA, el Alfy MS, Arafa MA, Salama MM, Habib KS. Serum levels of tumour necrosis factor alpha (TNF-alpha) versus immunoglobulins (IgG., IgM., and IgE.) in Egyptian scabietic children. J Egypt Soc Parasitol. 1995;25(3):773-786.
Galosi A, Dorn M, Ring J, Meurer M. Serum immunoglobulins in scabies. Hautarzt. 1982;33(6):329-330.
Hancock BW, Ward AM. Serum immunoglobulin in scabies. J Invest Dermatol. 1974;63(6):482-484. doi:10.1111/1523-1747.ep12680433
Şenol M, Özerol İ, Özerol E, Şaşmaz S, Turan F, Soytürk D. Serum immunoglobulin and complement levels in scabies. J Inonu Univ Med Faculty. 2010;4(1):37-39.
Falk ES. Serum IgE before and after treatment for scabies. Allergy. 1981;36(3):167-174. doi:10.1111/j.1398-9995.1981.tb01832.x
Abd El-Aal AA, Hassan MA, Gawdat HI, Ali MA, Barakat M. Immunomodulatory impression of anti and pro-inflammatory cytokines in relation to humoral immunity in human scabies. Int J Immunopathol Pharmacol. 2016;29(2):188-194. doi:10.1177/0394632015627464
Arlian LG, Morgan MS, Estes SA, Walton SF, Kemp DJ, Currie BJ. Circulating IgE in patients with ordinary and crusted scabies. J Med Entomol. 2004;41(1):74-77. doi:10.1603/0022-2585-41.1.74
Dougall A, Holt DC, Fischer K, Currie BJ, Kemp DJ, Walton SF. Identification and characterization of Sarcoptes scabiei and Dermatophagoides pteronyssinus glutathione S-transferases: implication as a potential major allergen in crusted scabies. Am J Trop Med Hyg. 2005;73(5):977-984. doi:10.4269/ajtmh.2005.73.977
Chevrant-Breton J, Desrues E, Auvray C, Guiguen C, De Certaines J. Serum IgE values in human scabies: study of 79 cases (author’s transl). Ann Dermatol Venereol. 1981;108(12):979-983.
Dahl JC, Scwartz B, Graudal CH, Christophersen J, Henrisken SA. Serum IgE antibodies to the scabies mite. Int J Dermatol. 1985;24(1):313-315. doi:10.1111/j.1365-4362.1985.tb05481.x
Morgan MS, Arlian LG. Serum antibody profiles of Sarcoptes scabiei infested or immunized rabbits. Folia Parasitol. 1994;41(3):223-227.
Bornstein S, Zakrisson G. Humoral antibody response to experimental Sarcoptes scabiei var. vulpes infection in the dog. Vet Dermatol. 1993;4(3):107-110. doi:10.1111/j.1365-3164.1993.tb00202.x
Casais R, Dalton KP, Millán J, et al. Primary and secondary experimental infestation of rabbits (Oryctolagus cuniculus) with Sarcoptes scabiei from a wild rabbit: factors determining resistance to reinfestation. Vet Parasitol. 2014;203(1-2):173-183. doi:10.1016/j.vetpar.2014.03.001
Tarigan S, Huntley JF. Failure to protect goats following vaccination with soluble proteins of Sarcoptes scabiei: evidence for a role for IgE antibody in protection. Vet Parasitol. 2005;133(1):101-109. doi:10.1016/j.vetpar.2005.03.044
Rodríguez-Cadenas F, Carbajal-González MT, Fregeneda-Grandes JM, Aller-Gancedo JM, Rojo-Vázquez FA. Clinical evaluation and antibody responses in sheep after primary and secondary experimental challenges with the mange mite Sarcoptes scabiei var. ovis. Vet Immunol Immunopathol. 2010;133(2-4):109-116. doi:10.1016/j.vetimm.2009.07.004
Tarigan S. Antibody responses in naïve and sensitised goats infested by Sarcoptes scabiei. Indonesian J Anim Vet Sci. 2004;9(4):258-265.
Rampton M, Walton SF, Holt DC, et al. Antibody responses to Sarcoptes scabiei apolipoprotein in a porcine model: relevance to immunodiagnosis of recent infection. PLoS One. 2013;44(6): doi:10.1371/journal.pone.0065354
Hoefling KK, Schroeter AL. Dermatoimmunopathology of scabies. J Am Acad Dermatol. 1980;3(3):237-240. doi:10.1016/S0190-9622(80)80184-8
Morsy GH, Gaafar SM. Responses of immunoglobulin-secreting cells in the skin of pigs during Sarcoptes scabiei infestation. Vet Parasitol. 1989;33(2):165-175. doi:10.1016/0304-4017(89)90064-2
Hayashi M, Uchiyama M, Nakajima H, Nagai R. The immunohistopathological study of scabies by the PAP method - identification of IgE positive mast cells. J Dermatol. 1986;13(1):70-73. doi:10.1111/j.1346-8138.1986.tb02904.x
Moustafa EH, el-Kadi MA, al-Zeftawy AH, Singer HM, Khalil KA The relation between scabies and hypersensitivity to antigens of house dust mites and storage mites. J Egypt Soc Parasitol. 1998;28(3):777-787.
Toet HM, Fischer K, Mounsey KE, Sandeman RM. Autoantibodies to iron-binding proteins in pigs infested with Sarcoptes scabiei. Vet Parasitol. 2014;205(1-2):263-270. doi:10.1016/j.vetpar.2014.07.012
Zalunardo M, Cargill CF, Sandeman RM. Identification of auto-antigens in skin scrapings from scabies-infected pigs. Int J Parasitol. 2006;36(10-11):1133-1141. doi:10.1016/j.ijpara.2006.06.002
Arlian LG, Feldmeier H, Morgan MS. The potential for a blood test for scabies. PLoS Negl Trop Dis. 2015;9(10): doi:10.1371/journal.pntd.0004188
Morgan MS, Arlian LG, Estes SA. Skin test and radioallergosorbent test characteristics of scabietic patients. Am J Trop Med Hyg. 1997;57(2):190-196. doi:10.4269/ajtmh.1997.57.190
Moog F, Brun J, Bourdeau P, Cadiergues MC. Clinical, parasitological, and serological follow-up of dogs with sarcoptic mange treated orally with lotilaner. Case Rep Vet Med. 2021;2021:1-8. doi:10.1155/2021/6639017
Falk ES, Dale S, Bolle R, Haneberg B. Antigens common to scabies and house dust mites. Allergy. 1981;36(4):233-238. doi:10.1111/j.1398-9995.1981.tb01568.x
Rambozzi L, Menzano A, Molinar Min AR, Rossi L. Immunoblot analysis of IgG antibody response to Sarcoptes scabiei in swine. Vet Immunol Immunopathol. 2007;115(1-2):179-183. doi:10.1016/j.vetimm.2006.10.006
Sarasa M, Rambozzi L, Rossi L, et al. Sarcoptes scabiei: specific immune response to sarcoptic mange in the Iberian ibex Capra pyrenaica depends on previous exposure and sex. Exp Parasitol. 2010;124(3):265-271. doi:10.1016/j.exppara.2009.10.008
de Oliveira VL, Keijsers RRMC, van de Kerkhof PCM, et al. Humanized mouse model of skin inflammation is characterized by disturbed keratinocyte differentiation and influx of IL-17A producing T cells. PLoS One. 2012;7(10): doi:10.1371/journal.pone.0045509
Nørreslet LB, Agner T, Clausen ML. The skin microbiome in inflammatory skin diseases. Curr Dermatol Rep. 2020;9(2):141-151. doi:10.1007/s13671-020-00297-z
Mikszta JA, Laurent PE. Cutaneous delivery of prophylactic and therapeutic vaccines: historical perspective and future outlook. Exp Rev Vacc. 2008;7(9):1329-1339. doi:10.1586/14760584.7.9.1329
Criscuolo E, Caputo V, Diotti RA, Sautto GA, Kirchenbaum GA, Clementi N. Alternative methods of vaccine delivery: an overview of edible and intradermal vaccines. J Immunol Res. 2019;2019:1-13. doi:10.1155/2019/8303648