Asymmetric Henry Reaction of Trifluoromethyl Enones with Nitromethane Using a N,N-Dibenzyl Diaminomethylenemalononitrile Organocatalyst.
Henry reaction
asymmetric reaction
nitromethane
organocatalyst
trifluoromethyl enone
Journal
Chemistry, an Asian journal
ISSN: 1861-471X
Titre abrégé: Chem Asian J
Pays: Germany
ID NLM: 101294643
Informations de publication
Date de publication:
14 Feb 2022
14 Feb 2022
Historique:
revised:
17
12
2021
received:
16
11
2021
pubmed:
21
12
2021
medline:
16
2
2022
entrez:
20
12
2021
Statut:
ppublish
Résumé
A novel N,N-dibenzyl diaminomethylenemalononitrile organocatalyst efficiently promoted asymmetric Henry reactions of trifluoromethyl enones with nitromethane, affording corresponding highly functionalized products in high yields with excellent enantioselectivities (up to 90% ee). This study is the first to report the successful example of the asymmetric 1,2-additions of nitromethane to trifluoromethyl enones.
Identifiants
pubmed: 34927372
doi: 10.1002/asia.202101299
doi:
Substances chimiques
Nitroparaffins
0
Methane
OP0UW79H66
nitromethane
RU5WG8C3F4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202101299Subventions
Organisme : JSPS KAKENHI
ID : 20K06948
Informations de copyright
© 2021 Wiley-VCH GmbH.
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