[Therapeutic applications of extracellular vesicles].
Applications thérapeutiques des vésicules extracellulaires.
Journal
Medecine sciences : M/S
ISSN: 1958-5381
Titre abrégé: Med Sci (Paris)
Pays: France
ID NLM: 8710980
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
entrez:
20
12
2021
pubmed:
21
12
2021
medline:
1
4
2022
Statut:
ppublish
Résumé
Extracellular vesicles, secreted spontaneously or in response to stress by all cell types, are proposed as alternative biotherapies to cellular therapies and to synthetic nanomedicines. Their logistical advantages (storage, stability, availability, tolerance), their ability to cross biological barriers, to deliver their contents (proteins, lipids and nucleic acids) in order to modify their target cells, as well as their immunomodulatory and regenerative activities, are of growing interest for a very wide spectrum of diseases. Here we review the challenges to bring these biotherapies to the clinic and discuss some promising applications in cancer and regenerative medicine. Applications thérapeutiques des vésicules extracellulaires. Les vésicules extracellulaires, sécrétées spontanément ou en réponse à un stress par tous les types cellulaires, sont proposés comme des biothérapies alternatives aux thérapies cellulaires et aux nanomédicaments synthétiques. Leurs atouts logistiques (stockage, stabilité, disponibilité, tolérance), leur capacité à franchir les barrières biologiques, à délivrer leurs contenus (protéines, lipides et acides nucléiques) pour modifier leurs cellules cibles, ainsi que leurs activités immunomodulatrice et régénérative, suscitent un intérêt grandissant pour un très large spectre de maladies. Cette synthèse présente les défis qui restent à relever pour appliquer ces biothérapies en clinique. Quelques applications prometteuses dans les domaines du cancer et de la médecine régénérative seront proposées.
Autres résumés
Type: Publisher
(fre)
Applications thérapeutiques des vésicules extracellulaires.
Identifiants
pubmed: 34928219
doi: 10.1051/medsci/2021207
pii: msc200672
doi:
Types de publication
Journal Article
Review
Langues
fre
Sous-ensembles de citation
IM
Pagination
1146-1157Subventions
Organisme : Region Ile de France
ID : Sesame 2019 IVETh EX047011
Organisme : IdEx Université de Paris, Agence Nationale de la Recherche
ID : ANR-18-IDEX-0001
Informations de copyright
© 2021 médecine/sciences – Inserm.
Références
Verma M, Lam TK, Hebert E, et al. Extracellular vesicles: potential applications in cancer diagnosis, prognosis, and epidemiology. BMC Clin Pathol 2015 ; 15 :
Saint-Pol J, Gosselet F, Duban-Deweer S, et al. Targeting and Crossing the Blood-Brain Barrier with Extracellular Vesicles. Cells 2020; 9 : 851.
Wiklander OPB, Brennan MÁ, Lötvall J, et al. Advances in therapeutic applications of extracellular vesicles. Sci Transl Med 2019; 11 : eaav8521.
Nagelkerke A, Ojansivu M, Koog L van der, et al. Extracellular vesicles for tissue repair and regeneration: evidence, challenges and opportunities. Adv Drug Deliv Rev 2021; 175 : 113775.
Elsharkasy OM, Nordin JZ, Hagey DW, et al. Extracellular vesicles as drug delivery systems: Why and how? Adv Drug Deliv Rev 2020; 159 : 332–43.
Lener T, Gimona M, Aigner L, et al. Applying extracellular vesicles based therapeutics in clinical trials – an ISEV position paper. J Extracell Vesicles 2015; 4.
Théry C, Witwer KW, Aikawa E, et al. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles 2018 ; 7 : 1535750.
Rohban R, Pieber TRMesenchymal Stem and Progenitor Cells in Regeneration: Tissue Specificity and Regenerative Potential. Stem Cells Int 2017 ; 2017 : e5173732.
Grangier A, Branchu J, Volatron J, et al. Technological advances towards extracellular vesicles mass production. Adv Drug Deliv Rev 2021; 113843.
Piffoux M, Nicolás-Boluda A, Mulens-Arias V, et al. Extracellular vesicles for personalized medicine: The input of physically triggered production, loading and theranostic properties. Adv Drug Deliv Rev 2019 ; 138 : 247–258.
Anne-Clémence Vion, Bhama Ramkhelawon, Xavier Loyer, et al. Shear Stress Regulates Endothelial Microparticle Release. Circul Res 2013 ; 112 : 1323–1333.
Pinto A, Marangon I, Méreaux J, et al. Immune Reprogramming Precision Photodynamic Therapy of Peritoneal Metastasis by Scalable Stem-Cell-Derived Extracellular Vesicles. ACS Nano 2021; 15 : 3251–63.
Berger A, Araújo-Filho I, Piffoux M, et al. Local administration of stem cell-derived extracellular vesicles in a thermoresponsive hydrogel promotes a pro-healing effect in a rat model of colo-cutaneous post-surgical fistula. Nanoscale 2021; 13 : 218–32.
Aubertin K, Silva AKA, Luciani N, et al. Massive release of extracellular vesicles from cancer cells after photodynamic treatment or chemotherapy. Sci Rep 2016 ; 6 : 35376.
Keklikoglou I, Cianciaruso C, Güç E, et al. Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models. Nat Cell Biol 2019 ; 21 : 190–202.
Gauthier NC, Fardin MA, Roca-Cusachs P, et al. Temporary increase in plasma membrane tension coordinates the activation of exocytosis and contraction during cell spreading. Proc Natl Acad Sci U S A 2011 ; 108 : 14467–14472.
Bodin P, Burnstock GEvidence That Release of Adenosine Triphosphate From Endothelial Cells During Increased Shear Stress Is Vesicular. J Cardiovasc Pharmacol 2001 ; 38 : 900–908.
de Jong OG, Verhaar MC, Chen Y, et al. Cellular stress conditions are reflected in the protein and RNA content of endothelial cell-derived exosomes. J Extracell Vesicles 2012 ; 1 : 18396.
Park K-S, Bandeira E, Shelke GV, et al. Enhancement of therapeutic potential of mesenchymal stem cell-derived extracellular vesicles. Stem Cell Res Ther 2019 ; 10 : 288.
Staubach S, Bauer FN, Tertel T, et al. Scaled preparation of extracellular vesicles from conditioned media. Adv Drug Deliv Rev 2021; 177 : 113940.
Gupta D, Maria Zickler A, EL Andaloussi S. Dosing Extracellular Vesicles. Adv Drug Deliv Rev 2021; 113961.
Bonsergent E, Grisard E, Buchrieser J, et al. Quantitative characterization of extracellular vesicle uptake and content delivery within mammalian cells. Nat Commun 2021; 12 : 1864.
van Balkom BWM, Gremmels H, Giebel B, et al. Proteomic Signature of Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles. Proteomics 2019 ; 19 : 1800163.
Sebbagh AC, Rosenbaum B, Péré G, et al. Regenerative medicine for digestive fistulae therapy: benefits, challenges and promises of stem/stromal cells and emergent perspectives via their extracellular vesicles. Adv Drug Deliv Rev 2021; 113841.
Maumus M, Pers Y-M, Ruiz M, et al. Cellules souches mésenchymateuses et médecine régénératrice - Quel avenir pour l’arthrose ?. Med Sci (Paris) 2018 ; 34 : 1092–1099.
Kordelas L, Rebmann V, Ludwig A-K, et al. MSC-derived exosomes: a novel tool to treat therapy-refractory graft-versus-host disease. Leukemia 2014 ; 28 : 970–973.
Doeppner TR, Herz J, Görgens A, et al. Extracellular Vesicles Improve Post-Stroke Neuroregeneration and Prevent Postischemic Immunosuppression. Stem Cells Transl Med 2015 ; 4 : 1131–1143.
Liao Z, Liu H, Ma L, et al. Engineering Extracellular Vesicles Restore the Impaired Cellular Uptake and Attenuate Intervertebral Disc Degeneration. ACS Nano 2021; 15(9) : 14709–24.
Lai RC, Arslan F, Lee MM, et al. Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury. Stem Cell Res 2010 ; 4 : 214–222.
Clement O, Cellier C, Wilhelm C, et al. Compositions useful for mucosal healing. WO/2018/011192.
Silva AKA, Perretta S, Perrod G, et al. Thermoresponsive Gel Embedded with Adipose Stem-Cell-Derived Extracellular Vesicles Promotes Esophageal Fistula Healing in a Thermo-Actuated Delivery Strategy. ACS Nano 2018 ; 12 : 9800–9814.
Berger A, Caudron E, Perrod G, et al. Enhancing digestive fistula healing by the off-label use of a thermoresponsive vessel occluder polymer associated with esophageal stent placement: A case report. Clin Res Hepatol Gastroenterol 2021; 45 : 101474.
Coffin E, Grangier A, Perrod G, et al. Extracellular vesicles from adipose stromal cells combined with a thermoresponsive hydrogel prevent esophageal stricture after extensive endoscopic submucosal dissection in a porcine model. Nanoscale 2021; 13 : 14866–78.
Kervadec A, Bellamy V, El Harane N, et al. Cardiovascular progenitor-derived extracellular vesicles recapitulate the beneficial effects of their parent cells in the treatment of chronic heart failure. J Heart Lung Transplant 2016 ; 35 : 795–807.
Gao L, Wang L, Wei Y, et al. Exosomes secreted by hiPSC-derived cardiac cells improve recovery from myocardial infarction in swine. Sci Transl Med 2020; 12 : eaay1318.
El Harane N, Kervadec A, Bellamy V, et al. Acellular therapeutic approach for heart failure: in vitro production of extracellular vesicles from human cardiovascular progenitors. Eur Heart J 2018 ; 39 : 1835–1847.
Lima Correa B, El Harane N, Gomez I, et al. Extracellular vesicles from human cardiovascular progenitors trigger a reparative immune response in infarcted hearts. Cardiovascul Res 2021; 117 : 292–307.
Cosenza S, Ruiz M, Toupet K, et al. Mesenchymal stem cells derived exosomes and microparticles protect cartilage and bone from degradation in osteoarthritis. Sci Rep 2017 ; 7 : 16214.
Cosenza S, Toupet K, Maumus M, et al. Mesenchymal stem cells-derived exosomes are more immunosuppressive than microparticles in inflammatory arthritis. Theranostics 2018 ; 8 : 1399–1410.
Rozier P, Maumus M, Maria ATJ, et al. Mesenchymal stromal cells-derived extracellular vesicles alleviate systemic sclerosis via miR-29a-3p. J Autoimmun 2021; 121 : 102660.
Warnecke A, Prenzler N, Harre J, et al. First-in-human intracochlear application of human stromal cell-derived extracellular vesicles. J Extracell Vesicles 2021; 10 : e12094.
Warnecke A, Harre J, Staecker H, et al. Extracellular vesicles from human multipotent stromal cells protect against hearing loss after noise trauma in vivo. Clin Transl Med 2020; 10 : e262.
Piffoux M, Volatron J, Cherukula K, et al. Engineering and loading therapeutic extracellular vesicles for clinical translation: a data reporting frame for comparability. Adv Drug Deliv Rev 2021; 113972.
Piffoux M, Silva AKA, Wilhelm C, et al. Modification of Extracellular Vesicles by Fusion with Liposomes for the Design of Personalized Biogenic Drug Delivery Systems. ACS Nano 2018 ; 12 : 6830–6842.
Toledano Furman NE, Lupu-Haber Y, Bronshtein T, et al. Reconstructed Stem Cell Nanoghosts: A Natural Tumor Targeting Platform. Nano Lett 2013 ; 13 : 3248–3255.
Silva AKA, Kolosnjaj-Tabi J, Bonneau S, et al. Magnetic and Photoresponsive Theranosomes: Translating Cell-Released Vesicles into Smart Nanovectors for Cancer Therapy. ACS Nano 2013 ; 7 : 4954–4966.
Yakavets I, Francois A, Lamy L, et al. Effect of stroma on the behavior of temoporfin-loaded lipid nanovesicles inside the stroma-rich head and neck carcinoma spheroids. J Nanobiotech 2021; 19 : 3.
Jang SC, Economides KD, Moniz RJ, et al. ExoSTING, an extracellular vesicle loaded with STING agonists, promotes tumor immune surveillance. Commun Biol 2021; 4 : 1–17.
Chanut R, Petrilli VDétection de l’ADN cytosolique par la voie cGAS-STING - De l’immunité innée vers le contrôle de la tumorigenèse. Med Sci (Paris) 2019 ; 35 : 527–534.
Camargo LCB de, Guaddachi F, Bergerat D, et al. Extracellular vesicles produced by NFAT3-expressing cells hinder tumor growth and metastatic dissemination. Sci Rep 2020; 10 : 8964.
Perets N, Oron O, Herman S, et al. Exosomes derived from mesenchymal stem cells improved core symptoms of genetically modified mouse model of autism Shank3B. Molecular Autism 2020; 11 : 65.
Seras-Franzoso J, Díaz-Riascos ZV, Corchero JL, et al. Extracellular vesicles from recombinant cell factories improve the activity and efficacy of enzymes defective in lysosomal storage disorders. J Extracell Vesicles 2021; 10 : e12058.
Silva AKA, Morille M, Piffoux M, et al. Development of extracellular vesicle-based medicinal products: a position paper of the group Extracellular Vesicle translatiOn to clinicaL perspectiVEs - EVOLVE France. Adv Drug Deliv Rev 2021; 179 : 114001.