Increased structural covariance in brain regions for number processing and memory in children with developmental dyscalculia.
brain volume
children
developmental dyscalculia
magnetic resonance imaging
maturation
number processing
structural covariance
Journal
Journal of neuroscience research
ISSN: 1097-4547
Titre abrégé: J Neurosci Res
Pays: United States
ID NLM: 7600111
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
revised:
19
10
2021
received:
05
05
2021
accepted:
18
11
2021
pubmed:
22
12
2021
medline:
1
4
2022
entrez:
21
12
2021
Statut:
ppublish
Résumé
Developmental dyscalculia (DD) is a developmental learning disability associated with deficits in processing numerical and mathematical information. Several studies demonstrated functional network alterations in DD. Yet, there are no studies, which examined the structural network integrity in DD. We compared whole-brain maps of volume based structural covariance between 19 (4 males) children with DD and 18 (4 males) typically developing children. We found elevated structural covariance in the DD group between the anterior intraparietal sulcus to the middle temporal and frontal gyrus (p < 0.05, corrected). A hippocampus subfield analysis showed higher structural covariance in the DD group for area CA3 to the parahippocampal and calcarine sulcus, angular gyrus and anterior part of the intraparietal sulcus as well as to the lingual gyrus. Lower structural covariance in this group was seen for the subiculum to orbitofrontal gyrus, anterior insula and middle frontal gyrus. In contrast, the primary motor cortex (control region) revealed no difference in structural covariance between groups. Our results extend functional magnetic resonance studies by revealing abnormal gray matter integrity in children with DD. These findings thus indicate that the pathophysiology of DD is mediated by both structural and functional abnormalities in a network involved in number processing and memory function.
Identifiants
pubmed: 34933406
doi: 10.1002/jnr.24998
pmc: PMC9306474
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
522-536Informations de copyright
© 2021 The Authors. Journal of Neuroscience Research published by Wiley Periodicals LLC.
Références
Science. 2010 Sep 10;329(5997):1358-61
pubmed: 20829489
Neuroimage. 2010 Jul 1;51(3):943-51
pubmed: 20211265
Neuropsychology. 2010 Mar;24(2):258-63; discussion 264-266
pubmed: 20230119
Neuroimage. 1999 Feb;9(2):179-94
pubmed: 9931268
Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):14755-62
pubmed: 18812502
Behav Brain Funct. 2006 Sep 05;2:31
pubmed: 16953876
Neuroscientist. 2013 Dec;19(6):616-28
pubmed: 24047610
Nat Commun. 2015 Sep 30;6:8453
pubmed: 26419418
Front Psychol. 2013 Aug 05;4:489
pubmed: 23935586
Dev Neuropsychol. 2011;36(6):763-87
pubmed: 21761997
Neuropsychologia. 2009 Jan;47(2):604-8
pubmed: 19007800
Neuroimage. 2010 Oct 15;53(1):1-15
pubmed: 20547229
Aging Cell. 2014 Dec;13(6):1068-74
pubmed: 25257192
J Anat. 2005 Jul;207(1):3-17
pubmed: 16011542
J Comp Neurol. 2006 Mar 1;495(1):53-69
pubmed: 16432904
Neuroimage. 2012 Nov 1;63(2):754-9
pubmed: 22776455
J Cogn Neurosci. 2010 May;22(5):860-74
pubmed: 19366284
Nat Rev Neurosci. 2013 May;14(5):322-36
pubmed: 23531697
Prog Neurobiol. 2001 Jun;64(2):129-55
pubmed: 11240210
Neuroimage. 2012 Jul 16;61(4):1428-43
pubmed: 22446492
IEEE Trans Med Imaging. 1998 Feb;17(1):87-97
pubmed: 9617910
J Neurol Neurosurg Psychiatry. 2013 Aug;84(8):875-81
pubmed: 23463873
Neuron. 2003 Nov 13;40(4):847-58
pubmed: 14622587
Science. 2011 May 27;332(6033):1049-53
pubmed: 21617068
J Clin Exp Neuropsychol. 2004 Feb;26(1):105-14
pubmed: 14972698
Cortex. 2013 Nov-Dec;49(10):2674-88
pubmed: 23890692
Psychol Bull. 1993 Sep;114(2):345-62
pubmed: 8416036
Prog Brain Res. 1990;83:47-58
pubmed: 2392570
J Neurosci. 2013 Feb 13;33(7):2889-99
pubmed: 23407947
Brain Struct Funct. 2016 Jul;221(6):3237-58
pubmed: 26336951
Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19067-72
pubmed: 20956328
Cognition. 2007 Mar;102(3):361-95
pubmed: 16488405
Rev Neurol. 2010 Jan 1-15;50(1):39-46
pubmed: 20073022
Dev Sci. 2016 Jul;19(4):613-31
pubmed: 26874919
Neuroimage. 2011 Feb 1;54(3):2382-93
pubmed: 20946958
PLoS One. 2013 Dec 09;8(12):e83722
pubmed: 24349547
Neuroimage. 2012 Jan 16;59(2):1239-48
pubmed: 21884805
Cereb Cortex. 2005 Nov;15(11):1676-89
pubmed: 15703252
Neuroimage Clin. 2018 Feb 05;18:356-366
pubmed: 29487792
Neuroimage. 2012 Oct 1;62(4):2296-314
pubmed: 22387165
Neuroimage. 2010 Nov 15;53(3):1135-46
pubmed: 20006715
Dev Sci. 2015 May;18(3):351-72
pubmed: 25098903
Alcohol Clin Exp Res. 2010 Aug;34(8):1450-64
pubmed: 20528824
Arch Neurol. 1996 Jan;53(1):88-96
pubmed: 8599565
Transl Psychiatry. 2018 Dec 10;8(1):273
pubmed: 30531959
Philos Trans R Soc Lond B Biol Sci. 2006 Sep 29;361(1473):1531-44
pubmed: 16939973
Cereb Cortex. 2017 Feb 1;27(2):1125-1136
pubmed: 26656727
Neuroimage. 2008 Jan 1;39(1):417-22
pubmed: 17928237
Nat Neurosci. 2014 Sep;17(9):1263-9
pubmed: 25129076
J Neurosci. 2015 Sep 9;35(36):12574-83
pubmed: 26354922
Neuropsychologia. 1971 Mar;9(1):97-113
pubmed: 5146491
Neuroimage Clin. 2013 Oct 14;4:18-28
pubmed: 24266008
J Neurosci Res. 2022 Feb;100(2):522-536
pubmed: 34933406
Dev Cogn Neurosci. 2018 Apr;30:291-303
pubmed: 28442224
Neurosci Biobehav Rev. 2009 Jun;33(6):909-25
pubmed: 19428500
J Learn Disabil. 2004 Jan-Feb;37(1):4-15
pubmed: 15493463
Trends Cogn Sci. 2017 Jan;21(1):32-45
pubmed: 27865786
Netw Neurosci. 2017 Oct 01;1(3):302-323
pubmed: 29855624
Curr Biol. 2007 Dec 18;17(24):R1042-3
pubmed: 18088583
Dev Sci. 2020 Jul;23(4):e12910
pubmed: 31599035
Neuroimage. 2001 Feb;13(2):314-27
pubmed: 11162272
Behav Brain Funct. 2009 Aug 05;5:35
pubmed: 19653919
Dev Sci. 2016 Sep;19(5):817-33
pubmed: 26227387
Cereb Cortex. 2008 Sep;18(9):2141-57
pubmed: 18245042
Neuroimage. 2019 Apr 15;190:289-302
pubmed: 29885484
Front Hum Neurosci. 2009 Nov 24;3:51
pubmed: 20046827
Child Dev. 2011 Jul-Aug;82(4):1224-37
pubmed: 21679173
Neuron. 2002 Jan 31;33(3):341-55
pubmed: 11832223
Neuroimage. 2020 Apr 15;210:116563
pubmed: 31972281
Int J Imaging Syst Technol. 2012 Mar 1;22(1):81-96
pubmed: 22368322
Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):18191-6
pubmed: 20921389
Child Dev. 2003 May-Jun;74(3):834-50
pubmed: 12795393
Pediatr Clin North Am. 1968 Aug;15(3):651-68
pubmed: 4174924
Curr Opin Neurobiol. 2004 Apr;14(2):218-24
pubmed: 15082328
Neuroimage. 2004;23 Suppl 1:S69-84
pubmed: 15501102
Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):E4997-5006
pubmed: 25368199
Dev Neuropsychol. 2011;36(6):741-62
pubmed: 21761996
Cortex. 2014 Aug;57:143-55
pubmed: 24858066
Neuroimage. 2011 Aug 1;57(3):782-95
pubmed: 21295145
J Vis. 2020 Aug 3;20(8):7
pubmed: 32756882
Neuroimage. 1999 Feb;9(2):195-207
pubmed: 9931269
Neuroimage. 2013 Jul 1;74:58-69
pubmed: 23428569
Brain Struct Funct. 2014 Sep;219(5):1721-33
pubmed: 23783231
Neuroimage. 2004 Jul;22(3):1060-75
pubmed: 15219578
Dev Cogn Neurosci. 2012 Feb 15;2 Suppl 1:S152-66
pubmed: 22682904
Dev Med Child Neurol. 1996 Jan;38(1):25-33
pubmed: 8606013
Dev Neuropsychol. 2008;33(4):447-73
pubmed: 18568899