Tufted astrocyte-like glia in two autopsy cases of multiple system atrophy: Is it a concomitant neurodegenerative disorder with multiple system atrophy and progressive supranuclear palsy?
four-repeat tau
multiple system atrophy
progressive supranuclear palsy
synucleinopathies
tufted astrocyte
Journal
Neuropathology : official journal of the Japanese Society of Neuropathology
ISSN: 1440-1789
Titre abrégé: Neuropathology
Pays: Australia
ID NLM: 9606526
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
revised:
29
08
2021
received:
22
07
2021
accepted:
31
08
2021
pubmed:
23
12
2021
medline:
4
2
2022
entrez:
22
12
2021
Statut:
ppublish
Résumé
Tufted astrocytes are one of the core histopathological features of progressive supranuclear palsy (PSP). To our knowledge, only three cases of multiple system atrophy (MSA) with PSP pathology have been reported. Here, we report two autopsy cases of MSA associated with the appearance of tufted astrocyte-like glia (TuALG). Clinically, the patients' symptoms were atypical of MSA; one showed vertical gaze palsy, and the other was a long-term survivor who progressed to a bedridden state shortly after the onset of the disease. These neuropathological observations were characterized by the copresence of MSA-specific changes and TuALG in some of the cerebral cortices but few or none of the other PSP tau pathologies. These cases might emphasize the significance of TuALG in non-PSP neurodegenerative disorders.
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
74-81Informations de copyright
© 2021 Japanese Society of Neuropathology.
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