rDromaserpin: A Novel Anti-Hemostatic Serpin, from the Salivary Glands of the Hard Tick
Hyalomma dromedarii
anticoagulants
salivary glands
serpin
thrombin inhibitor
Journal
Toxins
ISSN: 2072-6651
Titre abrégé: Toxins (Basel)
Pays: Switzerland
ID NLM: 101530765
Informations de publication
Date de publication:
20 12 2021
20 12 2021
Historique:
received:
28
10
2021
revised:
01
12
2021
accepted:
08
12
2021
entrez:
23
12
2021
pubmed:
24
12
2021
medline:
26
2
2022
Statut:
epublish
Résumé
Hemostatic disorders are caused either by platelet-related dysfunctions, defective blood coagulation, or by a combination of both, leading to an increased susceptibility to cardiovascular diseases (CVD) and other related illnesses. The unique specificity of anticoagulants from hematophagous arthropods, such as ticks, suggests that tick saliva holds great promise for discovering new treatments for these life-threatening diseases. In this study, we combined in silico and in vitro analyses to characterize the first recombinant serpin, herein called Dromaserpin, from the sialotranscriptome of the
Identifiants
pubmed: 34941750
pii: toxins13120913
doi: 10.3390/toxins13120913
pmc: PMC8703697
pii:
doi:
Substances chimiques
Anticoagulants
0
Serpins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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